Cellular and molecular biology of metals

With chapter contributions from more than 30 metal biology experts, Cellular and Molecular Biology of Metals explains the role of key divalent metal ions involved in the molecular and cellular biology of various target cell populations. Although it primarily focuses on homeostatic metals, such as nickel, zinc, and chromium, the text also discusses a few environmentally pertinent, toxic divalent cations, including mercury, cadmium, and arsenic.

This authoritative resource reviews the physiological mechanisms underlying the handling of essential and toxic metal ions, including metal ion homeostasis, metals and enzyme activity, metals and transcriptional regulation, and metal ion transport. It also analyzes other functions designed to avoid metal-induced toxicity and mediate the metal enhancement of cellular function.

The role of metal ions and their effect on mammalian cells and organs are only beginning to be truly defined. Cellular and Molecular Biology of Metals arms metals toxicologists and cellular and molecular biologists with the necessary knowledge they need to take the research effort to the next level.

Author Notes

Rudolfs K. Zalups, PhD, trained as a fellow and instructor at the Mayo Clinic, Yale University School of Medicine, University of Maryland School of Medicine, and the University of Rochester School of Medicine and Dentistry. He is now a professor at the Mercer University School of Medicine in Macon, Georgia.

James Koropatnick, PhD, is a Distinguished Oncology Scientist, Director of the LRCP Cancer Research Laboratory Program, Director of the UWO/CIHR Strategic Training Program in Cancer Research and Technology Transfer, Assistant Director of the Lawson Health Research Institute, and a Full Professor in the UWO Department of Oncology with cross-appointments in the UWO Departments of Microbiology and Immunology, Physiology and Pharmacology, and Pathology. He is also the Chief Scientific Officer of Sarissa, Inc. (a biotech discovery company) and sits on the Advisory Boards of Critical Outcomes Therapeutics, Inc., ID Laboratories, Inc., and MedVax Pharma, Inc.

David H. Petering and Rajendra Kothinti and Jeffrey Meeusen and Ujala RanaRudolfs K. Zalups and Christy C. BridgesNazzareno Ballatori and David A. Aremu and Michael S. MadejczykBruce A. FowlerKeith M. Erikson and Khristy J. Thompson and Michael AschnerJames KoropatnickDanuta S. Kalinowski and Des R. RichardsonHajo Haase and Wolfgang MaretLawrence H. LashChristy C. Bridges and Rudolfs K. ZalupsGregory A. AhearnAlan R. Parrish and Walter C. ProzialeckGiada Sebastiani and Kostas PantopoulosMichael A. Lynes and Kathryn Pietrosimone and Gregory Marusov and Douglas V. Donaldson and Clare Melchiorre and Xiuyun Yin and David A. Lawrence and Michael J. McCabe

Preface	p. v
Editors	p. vii
Contributors	p. ix
Chapter 1 Cellular Inorganic Chemistry Concepts and Examples	p. 1
Chapter 2 Molecular and Cellular Biology of Mercury in the Kidneys	p. 35
Chapter 3 Essential and Toxic Metal Transport in the Liver	p. 79
Chapter 4 Molecular and Cell Biology of Lead	p. 113
Chapter 5 Transport and Biological Impact of Manganese	p. 127
Chapter 6 Metallothionein and Metal Homeostasis	p. 143
Chapter 7 Cellular and Molecular Biology of Iron-Binding Proteins	p. 167
Chapter 8 The Regulatory and Signaling Functions of Zinc Ions in Human Cellular Physiology	p. 181
Chapter 9 Glutathione, Protein Thiols, and Metal Homeostasis	p. 213
Chapter 10 Ionic and Molecular Mimicry and the Transport of Metals	p. 241
Chapter 11 Heavy Metal Transport and Detoxification in Crustacean Gastrointestinal and Renal Epithelial Cells	p. 295
Chapter 12 Metals and Cell Adhesion Molecules	p. 327
Chapter 13 Iron Metabolism and Disease	p. 351
Chapter 14 Metal Influences on Immune Function	p. 379
Index	p. 415

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Author Notes

Table of Contents