Title:
CtBP family proteins
Series:
Molecular biology intelligence unit
Publication Information:
New York, NY : Springer Science+Business Media, 2007
ISBN:
9780387399713
Added Author:
Available:*
Library | Item Barcode | Call Number | Material Type | Item Category 1 | Status |
---|---|---|---|---|---|
Searching... | 30000010150989 | QP552.T68 C82 2006 | Open Access Book | Book | Searching... |
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Summary
Summary
This is a comprehensive monograph on the CtBP family proteins. These proteins are gaining wide scientific interest due to their critical roles in animal development in oncogenesis.
Table of Contents
Preface | p. ix |
1 CtBP Family Proteins: Unique Transcriptional Regulators in the Nucleus with Diverse Cytosolic Functions | p. 1 |
CtBP Family Proteins | p. 2 |
Nuclear Functions | p. 4 |
Cytosolic Functions of CtBP | p. 7 |
CtBPs in Central Nervous System Synapses | p. 8 |
Control of Plant Microtubule Cytoskeleton | p. 9 |
Role of CtBPs in Developmental Processes | p. 9 |
Role in Oncogenesis and Apoptosis | p. 10 |
2 Transcriptional Repression by the CtBP Corepressor in Drosophila | p. 18 |
Structure of the dCtBP Gene and Its Proteins | p. 18 |
Factors Interacting with dCtBP | p. 20 |
Short-Range Transcriptional Repression and dCtBP in the Early Embryo | p. 20 |
Histone-Modifying Enzymes and dCtBP | p. 23 |
dCtBP Interference with Hairy-Bound Groucho | p. 23 |
Multiple Repression Domains | p. 24 |
Role of dCtBP in Signaling Pathways | p. 24 |
Polycomb Group Proteins and dCtBP | p. 24 |
3 CtBP and Hematopoietic Transcriptional Regulators | p. 28 |
CtBP Proteins during Development | p. 28 |
CtBP Partnership with Hematopoietic Factors | p. 31 |
CtBPs in Leukemogenesis | p. 34 |
4 CtBP: A Link between Apoptosis and the Epithelial-Mesenchymal Transition | p. 39 |
Discovery of CtBP's Phenotypic Properties in Human Tumor Cells Using Ela as a Probe | p. 39 |
5 The Significance of the CtBP - AdE1A Interaction during Viral Infection and Transformation | p. 44 |
The Phenotype of an Adenovirus 12 E1A CtBP Binding Site Mutant | p. 46 |
Infection of Human Cells with Ad12/6f Virus | p. 51 |
Characterization of Rat Cells Transformed with Ad126fE1A | p. 52 |
The Effect of siRNA Knock-Down of CtBP Expression on Adenovirus Infection | p. 53 |
6 CtBP Proteins in Vertebrate Development | p. 61 |
CtBP Expression in Vertebrate Development | p. 61 |
Redundant and Nonredundant Roles of CtBP1 and CtBP2 in Development | p. 63 |
Developmental Genetics of CtBP | p. 65 |
7 CtBP as a Redox Sensor in Transcriptional Repression | p. 68 |
Differential Binding of CtBP to NAD+ and NADH | p. 68 |
NADH as Redox Indicator | p. 71 |
NADH-Dependent CtBP Binding to Repressors in Transcription Repression | p. 72 |
Biological Events Associated with NADH Level Fluctuation | p. 74 |
Redox Sensitive Nuclear Transcription Regulators | p. 74 |
8 CtBP Corepressor Complex-A Multi-Enzyme Machinery that Coordinates Chromatin Modifications | p. 77 |
Six Enzymes/Potential Enzymes in the CtBP Super-Complex | p. 77 |
Other Components and Target Genes of the CtBP Super Complex | p. 79 |
Summary and Perspectives | p. 80 |
9 Structural Determinants of CtBP Function | p. 83 |
CtBP: General Structural Considerations | p. 84 |
Dinucleotide Binding by CtBP | p. 86 |
Interaction of CtBP with Binding Partners | p. 88 |
Summary and Unresolved Questions | p. 90 |
10 CtBP3/BARS and Membrane Fission | p. 93 |
CtBP3/BARS as a Substrate of BFA-Dependent ADP-Ribosylation | p. 93 |
The CtBP3/BARS Fissioning Activity | p. 95 |
CtBP3/BARS in Mitotic Fragmentation of the Golgi Complex | p. 97 |
CtBP3/BARS as a Dual-Function Protein: The Molecular Switch | p. 100 |
11 CtBPs as Synaptic Proteins | p. 105 |
Chemical Synapses and Synaptic Transmission | p. 105 |
Ribbon Synapses | p. 105 |
The Novel CtBP Protein Ribeye Is a Component of Synaptic Ribbons | p. 106 |
CtBP1 Is Present at Both Ribbon and Conventional Chemical Synapses | p. 107 |
Diversity of CtBP Genes | p. 107 |
Functional Considerations | p. 107 |
12 A New Member of the CtBP/Bars Family from Plants: Angustifolia | p. 112 |
Angustifolia-A Polarity-Dependent Regulator of Leaf Cell Expansion | p. 112 |
Is AN a CtBP-Like Corepressor? | p. 114 |
Does AN Act as a Molecular Bridge as CtBPs? | p. 114 |
Is AN a Homolog of Bars? | p. 116 |
Conserved Function in Plants | p. 116 |
Perspective | p. 117 |
Index | p. 119 |