G. ChinnaduraiHitoshi Aihara and Lorena Perrone and Yutaka NibuAlexis Verger and Jose Perdomo and Merlin CrossleySteven M. FrischRoger J.A. Grand and Claire Baker and Paola M. Barral and Rachel K. Bruton and Julian Parkhill and Tadge Szestak and Philip H. GallimoreJeffrey D. HildebrandQinghong Zhang and Clark C. Fjeld and Amanda C. Nottke and Richard H. GoodmanYu-Jiang Shi and Yang ShiJames R. LundbladStefania Spano and Cristina Hidalgo Carcedo and Daniela CordaSusanne tom Dieck and Frank Schmitz and Johann Helmut BrandstatterHirokazu Tsukaya

Preface	p. ix
1 CtBP Family Proteins: Unique Transcriptional Regulators in the Nucleus with Diverse Cytosolic Functions	p. 1
CtBP Family Proteins	p. 2
Nuclear Functions	p. 4
Cytosolic Functions of CtBP	p. 7
CtBPs in Central Nervous System Synapses	p. 8
Control of Plant Microtubule Cytoskeleton	p. 9
Role of CtBPs in Developmental Processes	p. 9
Role in Oncogenesis and Apoptosis	p. 10
2 Transcriptional Repression by the CtBP Corepressor in Drosophila	p. 18
Structure of the dCtBP Gene and Its Proteins	p. 18
Factors Interacting with dCtBP	p. 20
Short-Range Transcriptional Repression and dCtBP in the Early Embryo	p. 20
Histone-Modifying Enzymes and dCtBP	p. 23
dCtBP Interference with Hairy-Bound Groucho	p. 23
Multiple Repression Domains	p. 24
Role of dCtBP in Signaling Pathways	p. 24
Polycomb Group Proteins and dCtBP	p. 24
3 CtBP and Hematopoietic Transcriptional Regulators	p. 28
CtBP Proteins during Development	p. 28
CtBP Partnership with Hematopoietic Factors	p. 31
CtBPs in Leukemogenesis	p. 34
4 CtBP: A Link between Apoptosis and the Epithelial-Mesenchymal Transition	p. 39
Discovery of CtBP's Phenotypic Properties in Human Tumor Cells Using Ela as a Probe	p. 39
5 The Significance of the CtBP - AdE1A Interaction during Viral Infection and Transformation	p. 44
The Phenotype of an Adenovirus 12 E1A CtBP Binding Site Mutant	p. 46
Infection of Human Cells with Ad12/6f Virus	p. 51
Characterization of Rat Cells Transformed with Ad126fE1A	p. 52
The Effect of siRNA Knock-Down of CtBP Expression on Adenovirus Infection	p. 53
6 CtBP Proteins in Vertebrate Development	p. 61
CtBP Expression in Vertebrate Development	p. 61
Redundant and Nonredundant Roles of CtBP1 and CtBP2 in Development	p. 63
Developmental Genetics of CtBP	p. 65
7 CtBP as a Redox Sensor in Transcriptional Repression	p. 68
Differential Binding of CtBP to NAD+ and NADH	p. 68
NADH as Redox Indicator	p. 71
NADH-Dependent CtBP Binding to Repressors in Transcription Repression	p. 72
Biological Events Associated with NADH Level Fluctuation	p. 74
Redox Sensitive Nuclear Transcription Regulators	p. 74
8 CtBP Corepressor Complex-A Multi-Enzyme Machinery that Coordinates Chromatin Modifications	p. 77
Six Enzymes/Potential Enzymes in the CtBP Super-Complex	p. 77
Other Components and Target Genes of the CtBP Super Complex	p. 79
Summary and Perspectives	p. 80
9 Structural Determinants of CtBP Function	p. 83
CtBP: General Structural Considerations	p. 84
Dinucleotide Binding by CtBP	p. 86
Interaction of CtBP with Binding Partners	p. 88
Summary and Unresolved Questions	p. 90
10 CtBP3/BARS and Membrane Fission	p. 93
CtBP3/BARS as a Substrate of BFA-Dependent ADP-Ribosylation	p. 93
The CtBP3/BARS Fissioning Activity	p. 95
CtBP3/BARS in Mitotic Fragmentation of the Golgi Complex	p. 97
CtBP3/BARS as a Dual-Function Protein: The Molecular Switch	p. 100
11 CtBPs as Synaptic Proteins	p. 105
Chemical Synapses and Synaptic Transmission	p. 105
Ribbon Synapses	p. 105
The Novel CtBP Protein Ribeye Is a Component of Synaptic Ribbons	p. 106
CtBP1 Is Present at Both Ribbon and Conventional Chemical Synapses	p. 107
Diversity of CtBP Genes	p. 107
Functional Considerations	p. 107
12 A New Member of the CtBP/Bars Family from Plants: Angustifolia	p. 112
Angustifolia-A Polarity-Dependent Regulator of Leaf Cell Expansion	p. 112
Is AN a CtBP-Like Corepressor?	p. 114
Does AN Act as a Molecular Bridge as CtBPs?	p. 114
Is AN a Homolog of Bars?	p. 116
Conserved Function in Plants	p. 116
Perspective	p. 117
Index	p. 119