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Cover image for The alkaloids : chemistry and biology
Title:
The alkaloids : chemistry and biology
Publication Information:
Amsterdam : Elsevier/Academic Press, 2006
Physical Description:
v. : ill. ; 25 cm.
ISBN:
9780124695634
General Note:
Cover title : volume 63

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30000010167538 QD421.A1 A44 2006 Open Access Book Book
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Summary

Summary

This series is world-renowned as the leading compilation of current reviews of this vast field. Internationally acclaimed for more than forty years, The Alkaloids: Chemistry and Biology, founded by the late Professor R.H.F. Manske, continues to provide outstanding coverage of this rapidly expanding field. Each volume provides, through its distinguished authors, up-to-date and detailed coverage of particular classes or sources of alkaloids.


Author Notes

Professor Emeritus Geoffrey A. Cordell obtained his Ph.D. in synthetic natural product chemistry at the University of Manchester in 1970. After two years as a NATO postdoctoral fellow at the Department of Chemistry, M.I.T., he joined the College of Pharmacy, University of Illinois at Chicago (UIC). A Professor since 1980, he served as a Department Head for 12 years and as Interim Dean of the College of Pharmacy for almost three years, as well as holding several other senior academic and research administrative positions at the Department, College, and Campus levels. He was the Co-founder of the US - Thai Consortium for Pharmacy Education, which developed and trained faculty for six new schools of pharmacy in Thailand. He retired from the University of Illinois in 2007. Since 1983, he has served as President of Natural Products Inc., a consulting company.

He is the author of about 600 research publications, book chapters, comprehensive reviews and professional publications; is the author of two books, with three more in progress; the editor of 37 books, including 29 volumes in the series "The Alkaloids: Chemistry and Biology"; is Associate Editor-in-Chief of the Chinese Journal of Natural Medicines; and a member of the Editorial Advisory Board of 26 international scientific journals. He is a former President of the American Society of Pharmacognosy, and is also an Honorary Member.

In 1981, he was an Alexander von Humboldt Fellow at the University of Munich with Professor Hildebert Wagner. He is an elected Fellow of the Royal Chemical Society, the Linnean Society of London, the American Society of Pharmacognosy, and the American Association of Pharmaceutical Scientists. In addition to assisting international organizations and corporations in several countries around the world to develop their research and academic programs, he is an Honorary Professor at Sichuan University, Chengdu, China; and at Amity University, Noida, India. He is also a Visiting Professor at universities in Peru, Malaysia, and Brasil, and an International Collaborative Partner of the UTAR Global Research Network in Malaysia in the areas of biodiversity and cancer. In addition, he is a member of the International Advisory Board of several natural product research institutes. His interests include the chemistry and biosynthesis of alkaloids, the sustainability and quality control of medicinal agents, the remote detection of biologically active natural products, and the use of vegetables as chemical reagents.


Table of Contents

Contributorsp. vii
Prefacep. ix
Regulation of Alkaloid Biosynthesis in PlantsPeter J. Facchini
I Introductionp. 1
II Alkaloid Biosynthetic Pathwaysp. 2
III Regulation of Alkaloid Biosynthesisp. 16
IV Applications of Genomics to the Study of Alkaloid Biosynthesisp. 28
V Metabolic Engineering of Alkaloid Pathwaysp. 29
VI Future Prospectsp. 34
Acknowledgmentsp. 35
Referencesp. 35
Ergot Alkaloids - Biology and Molecular BiologyChristopher L. Schardl and Daniel G. Panaccione and Paul Tudzynski
I Introductionp. 45
II Through the Ages: A History of Ergot Alkaloid Use, Abuse, and Poisoningp. 48
III Ergot Alkaloid Producersp. 50
IV Biosynthetic Pathways and Genesp. 53
V Routine Analytical Methods for Ergot Alkaloidsp. 75
VI Ergot Alkaloid Activities and Rolesp. 76
VII Summary and Conclusionsp. 80
Acknowledgmentsp. 82
Referencesp. 82
Chemical and Biological Aspects of Narcissus AlkaloidsJaume Bastida and Rodolfo Lavilla and Francesc Viladomat
I Introductionp. 87
II Narcissus Alkaloids and their Occurrencep. 91
III Biosynthetic Pathwaysp. 99
IV Synthetic Studiesp. 114
V Spectroscopy and Alkaloid Datap. 127
VI Biological and Pharmacological Activitiesp. 153
Referencesp. 163
Bisindole AlkaloidsToh-Seok Kam and Yeun-Mun Choo
I Introductionp. 182
II Indole-Indole and Tryptamine-Tryptamine Type, and Related Alkaloidsp. 182
III Tryptamine-Tryptamine Type with an Additional Monoterpene Unit and Related Alkaloidsp. 216
IV Corynanthe-Tryptamine Typep. 217
V Corynanthe-Corynanthe Typep. 223
VI Corynanthe-Strychnos Typep. 224
VII Vobasine-Tryptamine Typep. 228
VIII Vobasine-Vobasine Typep. 228
IX Vobasine-Akuammiline Typep. 230
X Vobasine-Vincorine Typep. 231
XI Bisindole Alkaloids from Alstoniap. 231
XII Akuammiline-Ajmaline Typep. 240
XIII Ajmaline-Vincorine Typep. 242
XIV Akuammiline-Vincorine Typep. 243
XV Akuammiline-Pleiocarpamine Typep. 245
XVI Vincorine-Vincorine Typep. 245
XVII Strychnos-Vobasine Typep. 247
XVIII Strychnos-Strychnos Typep. 248
XIX Secodine-Secodine Typep. 255
XX Apparicine-Vobasine Typep. 255
XXI Ellipticine-Ellipticine Typep. 257
XXII Iboga-Vobasine Typep. 258
XXIII Iboga-Iboga Typep. 269
XXIV Aspidosperma-Vobasine Typep. 270
XXV Aspidosperma-Vincorine Typep. 270
XXVI Aspidosperma-Macroline Typep. 271
XXVII Aspidosperma-Iboga Typep. 273
XXVIII Aspidosperma-Aspidosperma Typep. 274
XXIX Aspidosperma-Pseudoaspidosperma Typep. 286
XXX Aspidosperma-Eburnea Typep. 289
XXXI Aspidosperma-Canthinone Typep. 294
XXXII Eburnea-Eburnea Typep. 297
XXXIII Miscellaneous Bisindole Alkaloidsp. 298
XXXIV Aspidosperma-Cleavamine Typep. 300
Referencesp. 322
Cumulative Index of Titlesp. 339
Indexp. 347
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