Cover image for Adaptive phased array thermotherapy for cancer
Title:
Adaptive phased array thermotherapy for cancer
Personal Author:
Publication Information:
London; Artech House Publishers, 2009
Physical Description:
xiii, 226 p. : ill. ; 24 cm.
ISBN:
9781596933798

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30000010194935 RM865 F46 2009 Open Access Book
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Summary

Summary

Adaptive microwave phased array antennas are well known for their ability to improve the performance of communications and radar systems. and now, adaptive phased array techniques are beginning to be successfully applied to RF and microwave thermotherapy treatment of cancerous tumors. This groundbreaking book details innovative phased array techniques currently being developed at the MIT Lincoln Laboratory for cancer treatment. Until now, this material has only been available in Lincoln Laboratory reports and peer-reviewed journals. From electromagnetic field theory for tissue heating... to simulations of adaptive phased array thermotherapy for deep tumors of the torso... to coverage of arrays for tumors in the head, neck, breast, and chest wall, this timely resource offers you expert guidance in this emerging area. You also find an insightful look at future research topics for adaptive phased array thermotherapy.


Table of Contents

Prefacep. xi
1 Adaptive Phased Array Thermotherapy Techniquep. 1
1.1 Introductionp. 1
1.2 Background for Cancer Treatmentp. 8
1.3 Background for Thermotherapy Treatment of Cancerp. 9
1.4 Background for Delivering Thermotherapy to Deep Cancersp. 13
1.5 Adaptive Phased Array Thermotherapy Conceptp. 18
1.6 Summaryp. 22
Referencesp. 24
2 Adaptive Phased Array Algorithms for Thermotherapyp. 37
2.1 Introductionp. 37
2.2 Sample Matrix Inversion Algorithmp. 37
2.3 Gradient-Search Algorithmp. 45
2.4 Summaryp. 51
2.5 Problem Setp. 53
Referencesp. 53
3 Electromagnetic Field Theory for Tissue Heatingp. 57
3.1 Introductionp. 57
3.2 Wave Propagation in Conducting Mediap. 60
3.2.1 Maxwell's Electromagnetic Field Equationsp. 60
3.2.2 Vector Wave Equationp. 64
3.2.3 Electromagnetic Energy Flowp. 65
3.2.4 RF and Microwave Properties of Tissuep. 69
3.2.5 Ray-Tracing Analysis Techniquep. 71
3.3 Method of Moments Formulationp. 74
3.4 Finite-Difference Time-Domain Methodp. 79
3.5 Summaryp. 82
3.6 Problem Setp. 82
Referencesp. 87
4 Thermal Modeling Theory for Tissue Heatingp. 91
4.1 Introductionp. 91
4.2 Thermal Properties of Tissuep. 91
4.3 Bioheat Equationp. 92
4.4 Summaryp. 98
Referencesp. 99
5 Adaptive Array Simulations for the Torsop. 101
5.1 Introductionp. 101
5.2 Simulation Modelp. 102
5.3 Simulated Resultsp. 105
5.4 Summaryp. 110
Referencesp. 111
6 Phantom Studies for Deep Tumors in the Torsop. 115
6.1 Introductionp. 115
6.2 Methods and Materialsp. 117
6.2.1 Hyperthermia Phased Array Equipment Descriptionp. 117
6.2.2 Saline-Filled Cylindrical Phantom Descriptionp. 119
6.2.3 Heterogeneous Beef Phantom Descriptionp. 120
6.2.4 Light-Emitting Diode Saline-Filled Elliptical Phantom Descriptionp. 120
6.3 Measured Resultsp. 124
6.3.1 Saline-Filled Cylindrical Phantom: Two Adaptive Nullsp. 125
6.3.2 Saline-Filled Cylindrical Phantom: Adaptive Focusp. 127
6.3.3 One Adaptive Null for Heterogeneous Beef Phantomp. 129
6.3.4 Three Anterior Adaptive Nulls for LED Saline-Filled Elliptical Phantomp. 129
6.3.5 Three Lateral Adaptive Nulls for LED Saline-Filled Elliptical Phantomp. 133
6.4 Summaryp. 136
Referencesp. 137
7 Monopole Phased Array for Deep Cancerp. 141
7.1 Introductionp. 141
7.2 Methods and Materialsp. 142
7.3 Simulation Resultsp. 147
7.4 Summaryp. 151
Referencesp. 153
8 Adaptive Array for Breast Cancer: Preclinical Resultsp. 159
8.1 Introductionp. 159
8.2 Surgical Considerations for Breast Cancerp. 160
8.3 Microwave Thermotherapy Considerations for Breast Cancerp. 162
8.4 Adaptive Phased Array Thermotherapy System Concept for Breast Cancerp. 165
8.5 Adaptive Phased Array Algorithm for Focused Microwave Thermotherapyp. 168
8.6 Calculated Specific Absorption Rate for Breast Phantomp. 170
8.7 Clinical Adaptive Phased Array Thermotherapy System for Breast Cancerp. 173
8.8 Calculated Specific Absorption Rate Distribution for Breast Phantom with and without Tumorsp. 176
8.9 Measured Specific Absorption Rate Distribution for Breast Phantom with Variable-Size Tumorsp. 179
8.10 Measurements of Thermal Distribution in Animalsp. 183
8.11 Summaryp. 187
Referencesp. 188
9 Adative Array for Breast Cancer: Clinical Resultsp. 195
9.1 Introductionp. 195
9.2 Patients and Methodsp. 198
9.3 Resultsp. 200
9.4 Discussionp. 206
9.5 Summaryp. 208
Referencesp. 209
10 Future Studies of Adaptive Phased Arrays for Cancerp. 215
Referencesp. 217
About the Authorp. 221
Indexp. 223