Cover image for Leucocyte adhesion
Leucocyte adhesion
Current topics in membranes ; 64
Publication Information:
Burlington, MA : Academic Press, 2009
Physical Description:
xx, 397 p. : ill. (some col.) ; 24 cm.
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30000010218831 QP95 L47 2009 Open Access Book

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Current Topics in Membranes provides a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. This volume provides a review of the latest developments in leukocyte adhesion. Regulation of cell adhesion is important for immune system function.

Table of Contents

Contributorsp. xi
Forewordp. xiii
Previous Volumes in Seriesp. xvii
Section I Membrane Composition and Properties
Chapter 1 Membrane TethersRichard E. Waugh
I Overviewp. 3
II Introductionp. 4
III Tethers Formed from Bilayer Vesiclesp. 6
IV Tetheis Formed from Red Blood Cellsp. 10
V Tethers from Neutrophils and Other Cellsp. 16
VI Implications for Cell Adhesion in the Vasculaturep. 19
VII Conclusionp. 20
VIII Future Challengesp. 21
Referencesp. 22
Chapter 2 Biomechanics of Leukocyte and Endothelial Cell SurfaceJin-Yu Shao
I Overviewp. 25
II Introductionp. 26
III Surface Protrusion and Compressionp. 28
IV Flexural Stiffness of Leukocyte Microvillip. 32
V Membrane Tether Extractionp. 33
VI Impact of Surface Protrusion and Tether Extraction on Leukocyte Rollingp. 39
VII Concluding Remarksp. 40
Referencesp. 41
Chapter 3 The Cytoskeleton and Deform ability of White Blood CellsDamir B. Khismatullin
I Overviewp. 47
II Introductionp. 48
III Passive Deformation of the Cell Contributes to Cell Rollingp. 50
IV Integrin Activation and Cell Arrest are Dependent on Cell Deformabilityp. 57
V Firmly Adherent Cells Experience Active Deformationp. 60
VI Cytoskeleton is the Source of Bulk Mechanical Properties of White Blood Cellsp. 63
VII White Blood Cell Deformability can be Measured by Several Rheological Techniquesp. 72
VIII Reduced Deformability of White-Blood Cells Leads to Pathologiesp. 88
IX Concluding Remarksp. 90
Referencesp. 91
Section 2 Adhesion Molecules
Chapter 4 Activation of Leukocyte IntegrinsEun Jeong Park and Mototnu Shimaoka
I Overviewp. 115
II Leukocyte Integrinsp. 116
III Pathology of Integrin Function Deficiencyp. 117
IV Pathology Underlying the Aberrant Integrin Regulationp. 118
V Structures of Integrin Heterodimers and Integrin Domainsp. 119
VI Conformational Changes in the ¿ and ß I-Domainsp. 120
VII Global Conformational Changesp. 122
VIII Integrin Activation in Leukocyte-Endothelial Interactionsp. 123
IX Spatiotemporal Regulation of Integrin Activationp. 125
X The Role of Integrins in the Interstitial Migration of Leukocytesp. 126
XI Concluding Remarksp. 127
Referencesp. 128
Chapter 5 Cytoskeletal Interactions with Leukocyte and Endothelial Cell Adhesion MoleculesFredrick M. Pavalko
I Overviewp. 134
II Introductionp. 134
III Integrin Interactions with the Cytoskeletonp. 134
IV Integrin Cytoplasmic Domain-Binding Proteins in Leukocytesp. 138
V Selectin Interactions with the Cytoskeletonp. 142
VI Immunoglobulin Superfamily Interactions with the Cytoskeletonp. 146
VII Conclusionsp. 149
Referencesp. 149
Chapter 6 Membrane-Cytoskeletal Platforms for Rapid Chemokine Signaling to IntegrinsRonen Alon
I Overviewp. 158
II Introductionp. 159
III Leukocyte Integrin Activation at Endothelial Contactsp. 162
IV Signaling Events in Rapid Integrin Activation by GPCRsp. 172
V Membranal Platforms for Integrin Activation by Chemokine Signalsp. 178
VI Priming of Integrins to Chemokine Signaling in Rolling Leukocytesp. 181
VII Conclusionsp. 183
Referencesp. 184
Chapter 7 Biophysical Regulation of Selectin-Ligand Interactions Under FlowRodger P. McEver and Cheng Zhu
I Overviewp. 195
II Introductionp. 196
III Selectinsp. 197
IV Selectin Ligandsp. 197
V Kinetic and Mechanical Parameters of Cell Tethering and Roiling Under Flowp. 200
VI Force Free Kinetics and Affinity of Selectin-Ligand Interactionsp. 203
VII Mechanical Regulation of Selectin-Ligand Interactionsp. 204
VIII Flow-Enhanced Adhesion: The Shear Threshold Phenomenonp. 208
IX Cellular Features that Modulate Selectin-Mediated Leukocyte Rollingp. 211
X Conclusionsp. 214
Referencesp. 215
Chapter 8 Modeling Leukocyte RollingMaria K. Pospieszakka and Klaus Ley
I Overviewp. 221
II Motivation for Modeling Leukocyte Rollingp. 222
III History of Modeling Leukocyte Rollingp. 226
IV Development of a Leukocyte Rolling Modelp. 229
V Published Modeling Approachesp. 254
VI Future Directionsp. 264
Referencesp. 266
Section 3 Active Role of Endothelial Cells
Chapter 9 Endothelial Adhesive Platforms Organize Receptors to Promote Leukocyte ExtravasationOlga Barreiro
I Overviewp. 277
II Introductionp. 278
III The Emerging Concept of Endothelial Adhesive Platformsp. 283
IV Concluding Remarks and Therapeutic Perspectivesp. 288
V Technical Appendixp. 289
Referencesp. 291
Chapter 10 Transmigratory Cups and Invadosome-Like Protrusions: New Aspects of DiapedesisChristopher V. Carman
I Overviewp. 297
II Introductionp. 298
III Endothelial Transmigratory Cupsp. 302
IV Leukocyte Invadosome-Like Protrusionsp. 316
V Summary and Perspectivep. 326
Referencesp. 327
Chapter 11 How Endothelial Cells Regulate Transendothelial Migration of Leukocytes: Molecules and MechanismsWilliam A. Midler
I Overviewp. 335
II Introductionp. 336
III Endothelial Molecules Regulating Transmigrationp. 337
IV Mechanisms Regulating Transmigrationp. 342
V Epilogue: Unanswered Questionsp. 351
Referencesp. 351
Section 4 Methods
Chapter 12 Fluorescence Resonance Energy Transfer in the Studies of Integrin ActivationCraig T. Lefort and Minsoo Kim
I Overviewp. 360
II Fluorescent Biomoleculesp. 360
III Fluorescence Techniquesp. 366
IV Summaryp. 381
Referencesp. 382
Indexp. 389