Copper amine oxidases : structures, catalytic mechanisms, and role in pathophysiology

Although the amount of research on copper amine oxidases has grown rapidly and substantially in the past decade, the field unfortunately suffers from lack of cohesion and significant confusion surrounds aspects as simple as confirmation of enzyme identities. This book describes the structure of the enzymes, the role of copper, and of the unusual cofactor 6-hydroxydopa quinine derived from a posttranslational modification of a tyrosine residue. It also covers the differences of between AOs from bacteria, plants, and mammals. Finally, the text examines the importance of this ubiquitous class of enzymes in physiology and in metabolism of biogenic amines.

Franca BuffoniSinéad Boyce and Keith F. Tipton and Michael I. O'Sullivan and Gavin P. Davey and Martha Motherway Gildea and Andrew G. McDonald and Aldo Olivieri and Jeff O'SullivanShinnichiro Suzuki and Toshihide Okajima and Katsuyuki Tanizawa and Minae MureRosaria Medda and Andrea Bellelli and Pavel Pe&ccheck; and Rodolfo Federico and Alessandra Cona and Giovanni FlorisPaola Pietrangeli and Laura Morpurgo and Bruno Mondovì and Maria Luisa Di Paolo and Adelio RigoAndrew HoltIvo Frébort and Hubert G. SchwelbergerToshihide Okajima and Katsuyuki TanizawaJ. Mitchell Guss and Giuseppe Zanotti and Tiina A. SalminenFrans Boomsma and Anton H. van den Meiracker and Antonio ToninelloWieslawa Agnieszka Fogel and Ewa Toporowska-Kowalska and Anna StasiakChristian CarpénéPeter Boor and Mercedes Unzeta and Marko Salmi and Sirpa JalkanenMarek &Scheck;ebela and Lawrence M. SayreEmanuela Masini and Laura RaimondiMircea Alexandru Mateescu and Réginald NadeauRoberto StevanatoDavid M. Dooley

Acknowledgments	p. ix
Introduction: The Dawn of Pink Enzymes	p. xi
Editors	p. xv
Contributors	p. xvii
Abbreviations	p. xxi
Chapter 1 History	p. 1
Chapter 2 Nomenclature and Potential Functions of Copper Amine Oxidases	p. 5
Chapter 3 Cofactors of Amine Oxidases: Copper Ion and Its Substitution and the 2,4,5-Trihydroxylphenylalanine Quinone	p. 19
Chapter 4 Copper Amine Oxidases from Plants	p. 39
Chapter 5 Soluble Copper Amine Oxidases from Mammals	p. 51
Chapter 6 Membrane-Bound Copper Amine Oxidases	p. 69
Chapter 7 Copper Amine Oxidase Genes	p. 87
Chapter 8 Mechanism of TPQ Biogenesis in Prokaryotic Copper Amine Oxidase	p. 103
Chapter 9 Copper Amine Oxidase Crystal Structures	p. 119
Chapter 10 Plasma Amine Oxidases in Various Clinical Conditions and in Apoptosis	p. 143
Chapter 11 Copper Amine Oxidases in Intestinal Diseases	p. 159
Chapter 12 Copper Amine Oxidases in Adipose Tissue-Related Disorders	p. 177
Chapter 13 Copper Amine Oxidases in Adhesion Molecules in Renal Pathology and in Alzheimer's Disease and VAP-1 in Leukocyte Migration	p. 195
Chapter 14 Inhibitors of Copper Amine Oxidases: Past, Present, and Future	p. 219
Chapter 15 Pharmacological Applications of Copper Amine Oxidases	p. 239
Chapter 16 Copper Amine Oxidases as Antioxidant and Cardioprotective Agents	p. 253
Chapter 17 Biotechnological Aspects of Copper Amine Oxidases	p. 261
Chapter 18 Concluding Remarks	p. 275
References	p. 279
Index	p. 325

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