Cover image for Micro/nano technology systems for biomedical applications : microfluidics, optics, and surface chemistry
Micro/nano technology systems for biomedical applications : microfluidics, optics, and surface chemistry
Publication Information:
Oxford ; New York : Oxford University Press, 2010
Physical Description:
viii, 462 p. : ill. ; 24 cm.
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30000010274723 R857.N34 M536 2010 Open Access Book Book

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In daily life, we are accustomed to working with length scales of feet or meters, but the building blocks from which our bodies are constructed are many orders of magnitude smaller. The technologies that are being developed to intervene at these minute scales have the potential to improvehuman health and significantly enrich our lives.Revolutionary micro/nano technology platforms have led to dramatic advances in sample preparation, analysis and cell culture. From the 1990s through to the very beginning of the twenty-first century, the focus was on the development of manufacturing technologies. Through elegant design andsophisticated fabrication, the micro- to nano-scale manipulation of fluids and particles has become routine. Since then, it has become possible to control molecular interactions at device surfaces, and optical manipulation, imaging and sensing techniques can also be incorporated. Micro/nanotechnology platforms are already being used to study and direct biological processes at the cellular and sub-cellular level, and to detect disease with greater sensitivity and specificity. The challenges and excitement in the near future will be in engineering these sophisticated, multifunctionaldevices to seamlessly interface with complex biological systems.Providing a clear guide that moves from molecules through devices to systems, this book reviews fundamental aspects of microfluidic devices, including fabrication, surface property control, pressure-driven and electrokinetic flow, and functions such as fluid mixing, particle sorting and molecularseparations. The integration of optical and plasmonic imaging, optoelectronic tweezers for single particle manipulation, and optical and electrical signal transduction methods for biosensing are shown to provide extraordinary capabilities for bioanalytical and biomedical applications. Theserepresent key areas of research that will lead to the next generation of micro/nano-based systems. Anyone working in this fast-changing field will benefit from this comprehensive review of the latest thinking, while researchers will find much to inspire and direct their work.

Author Notes

Dr. Chih-Ming Ho received a B.S. from National Taiwan University and Ph.D. from Johns Hopkins University. He holds the Ben Rich-Lockheed Martin Professor at UCLA and is the Director of the Center for Cell Control. Dr. Ho is known for his work in micro/nano fluidics, bio-nano technologies andturbulence. He was ranked by ISI as one of the top 250 most cited researchers worldwide in the entire engineering category. In 1997, Dr. Ho was inducted as a member of the National Academy of Engineering. In the next year, he was elected as an Academician of Academia Sinica. Dr. Ho holds eighthonorary chair professorships. Dr. Ho is a Fellow of the American Physical Society as well as the American Institute of Aeronautics and Astronautics.

Table of Contents

Chih-Ming HoPatrick Tabeling and Yi-Kuen LeeNarayan R. Aluru and George Em KarniadakisScott Miserendino and Yu-Chong TaiHywel Morgan and Nicolas G. Green and Tao SunChang-Jin 'CJ' Kim and Jian GongCarl D. Meinhart and Steven T. WereleyYuan Wang and Xiang ZhangEric P. Y. Chiou and Ming C. WuTza-Huei Wang and Kelvin Liu and Hsin-Chih Yeh and Christopher M. PuleoRobin L. Garrell and Heather D. Maynard
List of Contributorsp. vii
1 Intersections between micro/nano technologies and biological sciencesp. 1
2 Micro/nanofluidic processesp. 33
3 Numerical simulation of microflows and nanoflowsp. 53
4 Pressure-driven microfluidicsp. 121
5 Electrokinetics of particles and fluidsp. 196
6 EWOD droplet microfluidic devices using printed circuit board fabricationp. 232
7 Micro particle velocimetryp. 266
8 Near-field optical and plasmonic imagingp. 298
9 Optoelectronic tweezersp. 317
10 Nanobiosensorsp. 346
11 Surface molecular property controlp. 395
Indexp. 437