Available:*
Library | Item Barcode | Call Number | Material Type | Item Category 1 | Status |
|---|---|---|---|---|---|
Searching... | 30000010263885 | QR96.5 F86 2011 f | Open Access Book | Book | Searching... |
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Summary
Summary
A primary component of cell signaling research, this title covers the principal membrane-bound receptor families, including their structural organization. Written and edited by experts in the field, this book provides up-to-date research on transmembrane signaling entities and their initiating responses following extracellular stimulation.
Author Notes
Ralph A. Bradshaw is Professor Emeritus in the Department of Physiology and biophysics at the University of California, Irvine. Prior to that he was on the faculty of the Department of Biological Chemistry, Washington University School of Medicine in St. Louis, MO and was Professor and Chair of the Department of Biological Chemistry at the University of California, Irvine. From 2006 to 2015, he was a member of the Mass Spectrometry Facility and Professor of Pharmaceutical Chemistry at the University of California, San Francisco. He holds degrees from Colby College and Duke University and was a post-doctoral fellow at Indiana University and the University of Washington. He has served as president for FASEB, was the founding president of the Protein Society and was the treasurer of the American Society for Biochemistry and Molecular Biology. His research has focused on protein chemistry and proteomics, with emphasis on the structure and function of growth factors and their receptors, particularly nerve growth factor and fibroblast growth factor, and the involvement of receptor tyrosine kinases in cell signalling. He has also studied in the role of proteolytic processing and N-terminal modification in protein stability and turnover.
Edward A. Dennis is Distinguished Professor and former Chair of the Department of Chemistry and Biochemistry and Professor in the Department of Pharmacology in the School of Medicine at the University of California, San Diego. He is also Editor-in-Chief of the Journal of Lipid Research.
Table of Contents
| 1 Cell Signaling: Yesterday, Today, and Tomorrow |
| 2 Structural and Energetic Basis of Molecular Recognition |
| 3 Free Energy Landscapes in Protein-Protein Interactions |
| 4 Molecular Sociology |
| 5 Antibody-Antigen Recognition and Conformational Changes |
| 6 Binding Energetics in Antigen-Antibody Interfaces |
| 7 Immunoglobulin-Fc Receptor Interactions |
| 8 Ig-Superfold and its Variable Uses in Molecular Recognition |
| 9 T Cell Receptor/pMHC Complexes |
| 10 Mechanistic Features of Cell Surface Adhesion Receptors |
| 11 The Immunological Synapse |
| 12 NK Receptors |
| 13 Carbohydrate Recognition and Signaling |
| 14 Rhinovirus-Receptor Interactions |
| 15 HIV-1 Receptor Interactions |
| 16 Influenza Virus Neuraminidase Inhibitors |
| 17 Structural Basis of Signaling Events Involving Fibrinogen and Fibrin |
| 18 Structural Basis of Integrin Signaling |
| 19 Structures of Heterotrimeric G Proteins and their Complexes |
| 20 G-Protein-Coupled Receptor Structures |
| 21 Toll-like Receptors - Structure and Signaling |
| 22 Variable Lymphocyte Receptors |
| 23 Structure and Function of G-Protein-Coupled Receptors: Lessons from Recent Crystal Structures |
| 24 Chemokines and Chemokine Receptors: Structure and Function |
| 25 The ?2 Adrenergic Receptor as a Model for G-Protein-Coupled Receptor Structure and Activation |
| 26 Protease-Activated Receptors |
| 27 Agonist-Induced Desensitization and Endocytosis of G-Protein-Coupled Receptors |
| 28 Functional Role(s) of Dimeric Complexes Formed from G-Protein-Coupled Receptors |
| 29 Chemotaxis Receptors in Bacteria: Transmembrane Signaling, Sensitivity, Adaptation, and Clustering |
| 30 An Overview of Ion Channel Structure |
| 31 Molecular Mechanism of Store-Operated Ca2+ Signaling and CRAC Channel Activation Mediated |
| 32 Ion Permeation: Mechanisms of Ion Selectivity and Block |
| 33 Nicotinic Acetylcholine Receptors |
| 34 Ion Channels Regulated by Direct Binding of Cyclic Nucleotides |
| 35 Overview of Cytokine Receptors |
| 36 Growth Hormone and Prolactin Family of Hormones and Receptors: The Structural Basis for Receptor Activation and Regulation |
| 37 Erythropoietin Receptor as a Paradigm for Cytokine Signaling |
| 38 The Fibroblast Growth Factor (FGF) Signaling Complex |
| 39 Structure of IFN-g and its Receptors |
| 40 Structure and Function of Tumor Necrosis Factor (TNF) at the Cell Surface |
| 41 The Mechanism of NGF Signaling Suggested by the p75 and TrkA Receptor Complexes |
| 42 The Mechanism of VEGFR Activation by VEGF |
| 43 Receptor-Ligand Recognition in the TGFb Superfamily as Suggested by Crystal Structures |
| 44 Insulin Receptor Complex and Signaling by Insulin |
| 45 Structure and Mechanism of the Insulin Receptor Tyrosine Kinase |
| 46 IL-21 Increased Potency Desig |
| 47 Signaling of IL-4R, a Typical Class I Cytokine Receptor: What Defines the Quiescent State? |
| 48 Epidermal Growth Factor Kinases and their Activation in Receptor Mediated Signaling |
| 49 Tumor Necrosis Factor Receptor-Associated Factors in Immune Receptor Signal Transduction |
| 50 Assembly of Signaling Complexes for TNF Receptor Family Molecules |
| 51 Mechanisms of CD40 Signaling in the Immune System |
| 52 Role of Lipid Domains in EGF Receptor Signaling |
| 53 Lipid-Mediated Localization of Signaling Proteins |
| 54 Organization of Photoreceptor Signaling Complexes |
| 55 Transmembrane Receptor Oligomerization |
