Precious metals for biomedical applications

Precious metals and semi-precious metals are used for an increasing number of medical applications due to the properties of these metals and their alloys. Precious Metals for Biomedical Applications reviews the properties of precious metals and their resulting applications in medicine.

Part one outlines the fundamentals of precious metals for biomedical applications, discussing their useful properties, such as biocompatibility and corrosion resistance. Part two goes on to provide an overview of the applications of precious metals in biomedicine, including dental, therapeutic, tissue engineering, and bioimaging applications. It discusses the advantages of the structure and properties of precious metals for these applications.

Precious Metals for Biomedical Applications is a key reference for material scientists and academics concerned with the properties and uses of these metals.

Author Notes

Niklaus Baltzer is Head of Materials Development at Cendres+Mtaux, Switzerland. Thierry Copponnex is Director of Development at Cendres+Mtaux, Switzerland.

N. Baltzer and T. CopponnexA. Johnson and T. ShiraishiS. J. MegremisM. Neshatian and C. Yang and N. Hegarty and D. B. ChithraniD. A. GivanB. K. Woodward and Johnson MattheyT. M. Martin and D. B. Robinson and R. J. NarayanX. Chen and Q. W. Li and X. M. WangM. Diba and A. R. Boccaccini

Contributor contact details	p. ix
Woodhead Publishing Series in Biomaterials	p. xi
Preface	p. xv
Part I Fundamentals of precious metals for biomedical applications	p. 1
1 Properties and processing of precious metal alloys for biomedical applications	p. 3
1.1 Introduction	p. 3
1.2 Some properties of precious metals	p. 4
1.3 Binary alloys	p. 9
1.4 Some selected alloys	p. 16
1.5 Testing methods	p. 17
1.6 Manufacturing processes	p. 25
1.7 Some special aspects	p. 26
1.8 Final remarks	p. 35
1.9 References	p. 35
2 Biocompatibility of precious metals for medical applications	p. 37
2.1 Introduction	p. 37
2.2 The selection, application and properties of precious metals currently being used in the human body	p. 39
2.3 A review of the literature relating to the biocompatibility of precious metals in the body	p. 42
2.4 The effects of alloying and microstructure of precious metal alloys on biocompatibility	p. 45
2.5 Concluson and future trends	p. 48
2.6 References	p. 49
3 Corrosion resistance of precious metals for biomedical applications	p. 56
3.1 Introduction	p. 56
3.2 Electrochemical thermodynamics and electrode potential	p. 57
3.3 Electrochemical kinetics	p. 63
3.4 Corrosion testing of precious metals for biomedical applications	p. 71
3.5 Corrosion and tarnish of precious metals for biomedical applications	p. 76
3.6 Acknowledgements	p. 84
3.7 References	p. 84
4 Optimizing the bio-nano interface for gold nanoparticles	p. 87
4.1 Introduction	p. 87
4.2 Intracellular uptake, transpot and excretion of nanoparticles	p. 89
4.3 Intracellular transport of nanoparticles	p. 97
4.4 Excretion of nanoparticles	p. 100
4.5 Conclusion	p. 101
4.6 References	p. 102
Part II Biomedical applications applications of precious metals	p. 107
5 Precious metal alloys for dental applications	p. 109
5.1 Introduction	p. 109
5.2 Classification of alloys in dentistry	p. 110
5.3 Requirements for dental restorations	p. 113
5.4 Restorative applications	p. 119
5.5 Alloys for attachments and other æCast-ToÆ applications	p. 123
5.6 Other applications in dentistry	p. 125
5.7 Conclusion and future trends	p. 125
5.8 Sources of further information and advice	p. 126
5.9 References	p. 127
6 Platinum group metals (PGMs) for permanent implantable electronic devices	p. 130
6.1 Introduction	p. 130
6.2 The advantages of platinum for implantable emdical devices	p. 133
6.3 Devices for cardiac rhythm management	p. 135
6.4 The manufacture of platinum biomedical components	p. 141
6.5 The coating of platinum biomedical machine part components	p. 144
6.6 Conclusion	p. 145
6.7 References	p. 145
7 Nanoporous gold for biomedical applications: structure, properties and applications	p. 148
7.1 Introduction	p. 148
7.2 Medical applications	p. 152
7.3 Biosensor applications	p. 154
7.4 Alloy formation	p. 155
7.5 Dealloying of gold-silver alloy	p. 156
7.6 Mechanical properties of nanoporous gold	p. 158
7.7 Electronic properties of nanoporous gold	p. 159
7.8 Conclusion	p. 160
7.9 References	p. 160
8 Gold nanostructures for bioimaging, drug delivery and therapeutics	p. 163
8.1 Introduction	p. 163
8.2 Gold for bioimaging and target drug delivery	p. 165
8.3 Gold for photothermal therapeutics	p. 171
8.4 Conclusions and future trends	p. 173
8.5 Acknowledgments	p. 173
8.6 References	p. 174
9 Silver-containing bioactive glasses for tissue engineering applications	p. 177
9.1 Introduction	p. 177
9.2 Synthesis techniques	p. 179
9.3 Properties of Ag-doped bioactive glasses	p. 182
9.4 Tissue engineering and other applications	p. 201
9.5 Conclusions and future trends	p. 205
9.6 Further information and advice	p. 207
9.7 References	p. 207
Index	p. 213

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