Cover image for Cell signalling
Title:
Cell signalling
Personal Author:
Edition:
3rd ed.
Publication Information:
Oxford ; New York : Oxford University Press, c2010
Physical Description:
xxii, 341 p. : ill. ; 25 cm.
ISBN:
9780199232109

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30000010274625 QH604.2 H36 2010 Open Access Book Book
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Summary

Summary

Signalling within and between cells is an essential part of many biological processes, from the development of the body, to the activity of our immune system. Recent advances in molecular cell biology have allowed us to identify the components of signalling pathways, and examine how they interact to form the carefully orchestrated and controlled networks upon which the complexity of a living organism is built.Starting with an overview of cell signalling and highlighting its importance in many biological systems, the book goes on to explore the key components of extracellular and intracellular signalling mechanisms, before examining how these components come together to create signalling pathways, which are so crucial to the survival of many living organisms.Cell Signalling presents a carefully structured introduction to this intricate subject, introducing those conserved features that underlie many different extra- and intracellular signalling systems. * A focus on generic components of extra- and intracellular signalling pathways allows the student to gain a thorough understanding of the underlying principles of cell signalling before exploring how the individual components inteeract to form complex signalling pathways* The ubiquity of key signalling mechanisms is highlighted, enabling students to see how similar mechanisms are conserved and harnessed in many different biological systems* The student is directed to carefully chosen further reading articles, allowing them to readily explore key topics in more detailThe Online Resource Centre to accompany Cell Signalling features:For students:* Links to useful websites* Hyperlinked referencesFor Lecturers:* All figures from the book


Author Notes

Dr John Hancock is Reader in Molecular Biology in the Faculty of Applied Science at the University of the West of England, Bristol, UK.


Table of Contents

Figure Legends
Preface
Abbreviations
Part I An overview of cell signalling
1 Aspects of cellular signalling
2 Pathways are the key to signalling
3 A look at some of the history and techniques of cell signalling
Part II Components which comprise signalling pathways
4 Extracellular signals: hormones, cytokines and growth factors
5 Detection of extracellular signals: the role of receptors
6 Protein Phosphorylation, kinases and phosphatases
7 Cyclic nucleotides, cyclases and G proteins
8 Inositol phosphate metabolism and roles of membrane lipids
9 Intracellular calcium: Its control and role as an intracellular signal
10 Reactive oxygen species, reactive nitrogen species and redox signalling
Part III Selected examples of signalling pathways and events
11 Insulin and the signal transduction cascades it invokes
12 Perception of the environment
13 Signalling in development and for the regulation of gene expression
14 Life, death and apoptosis
Part IV Final thoughts
15 Cell Signalling: importance, complexity, and future
Index