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Library | Item Barcode | Call Number | Material Type | Item Category 1 | Status |
|---|---|---|---|---|---|
Searching... | 30000010226194 | QD262 R424 2010 | Open Access Book | Book | Searching... |
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Summary
Summary
Edited by a top expert, this book represents a powerful tool showing how to successfully apply ESI-MS in revealing, elucidating and helping to consolidate several proposed mechanisms of organic reactions that need to be emphasized.
With a foreword by Chris Enke
Author Notes
Leonardo Silva Santos received is PhD from Unicamp University, Brazil, in 2003, working under the direction of Dr. A.R. Pilli. Following his PhD, Leonardo took up a postdoctoral position at the Thomson Mass Spectrometry Laboratory at the University of Campinas, where alongside Dr. M. Eberlin he established ESI-MS-based mechanistic studies in Brazil. He spent a time working as a Postdoc in the group of Jurgen Metzger at the Carl von Ossietzky University before moving to Chile. He is currently Full Professor at the Institute of Chemistry and Natural Resources at Talca University (Chile) and established the Laboratory of Asymmetric Synthesis. He is involved with the establishment of the Fraunhofer Institute in Chile and will head the chemistry group associated with the use of nanotechnology in agriculture. Professor Santos has published over 70 articles in the last four years, holds two international patents and has received numerous international honors and awards.
Table of Contents
| Foreword |
| Preface |
| List of Contributors |
| 1 A Brief Overview of the Mechanisms Involved in Electrospray Mass SpectrometryPaul Kebarle and Udo H. Verkerk |
| 1.1 Introduction |
| 1.2 Production of Gas-Phase Ions by Electrospray and Electrospray Ionization Mass Spectrometry |
| 2 Historical Perspectives in the Study of Ion Chemistry by Mass Spectrometry From the Gas Phase to SolutionHao Chen |
| 2.1 A Brief History and Recent Advances in Mass Spectrometry |
| 2.2 Overview of the Study of Ion/Molecule Reactions in the Gas Phase by Mass Spectrometry |
| 2.3 Future Perspectives |
| 3 Organic Reaction Studies by ESI-MSFabiane M. Nachtigall and Marcos N. Eberlin |
| 3.1 Introduction |
| 3.2 Reaction Mechanisms |
| 3.3 General Remarks |
| 4 Studies of Reaction Mechanism Intermediates by ESI-MSRong Qian and Jing Zhou and Shengjun Yao and Haoyang Wang and Yinlong Guo |
| 4.1 Introduction |
| 4.2 Studies on the Intermediates and Mechanisms of Pd-Catalyzed Reactions |
| 4.3 Studies on Some Reactive Intermediates and Mechanisms of Radical Reactions |
| 4.4 Studies on the Intermediates and Mechanism of Organocatalysis Reactions |
| 4.5 Studies on the Intermediates and Mechanism of Transition Metal-Catalyzed Polymerization Reactions |
| 5 On-line Monitoring Reactions by Electrospray Ionization Mass SpectrometryLeonardo S. Santos |
| 5.1 Introduction |
| 5.2 Preservation of the Charge in the Transit of Ions from Solution to the Gas Phase Using the ESI Technique |
| 5.3 Developing Methods to Study Reaction Mechanisms |
| 5.4 Probing Reactivity of Intermediates |
| 5.5 Conclusion |
| 6 Gas Phase Ligand Fragmentation to Unmask Reactive Metallic SpeciesRichard A. J. O.Hair |
| 6.1 Introduction and Scope of the Review |
| 6.2 Unmasking Reactive Metallic Intermediates via Collision-Induced Dissociation |
| 6.3 Conclusions |
| 7 Palladium Intermediates in SolutionAnna Roglans and Anna Pla-Quintana |
| 7.1 Introduction |
| 7.2 ESI-MS Studies in Suzuki-Miyaura Cross-Coupling and Related Reactions |
| 7.3 ESI-MS Studies in the Identification of Oxidative Addition Intermediates |
| 7.4 ESI-MS Studies in Mizoroki-Heck and Related Reactions |
| 7.5 ESI-MS Studies in Stille Cross-Coupling Reactions |
| 7.6 ESI-MS Studies in Palladium-Catalyzed Reactions Involving Allenes |
| 7.7 ESI-MS Studies in Palladium-Catalyzed Alkynylation Reactions |
| 7.8 ESI-MS Studies in Palladium-Catalyzed Allylic Substitution Reactions |
| 7.9 ESI-MS Studies in Palladium-Catalyzed Oxidation of 2-Allylphenols |
| 7.10 ESI-MS Studies in Palladium-Catalyzed Polymerization Reactions |
| 7.11 Conclusions |
| 8 Practical Investigation of Molecular and Biomolecular Noncovalent Recognition Processes in Solution by ESI-MSKevin A. Schug |
| 8.1 Introduction |
| 8.2 Methods and Applications |
| 8.3 Practical Aspects of Titration Analysis |
| 8.4 Summary and Outlook |
| References |
| Index |
