From bioimaging to biosensors : noble metal nanoparticles in biodetection

Title:

Publication Information:

Singapore : Pan Stanford Publishing, 2013

Physical Description:

ix, 298 pages, 12 pages of plates : illustrations (some color) ; 24 cm.

ISBN:

9789814267243

Subject Term:

Added Author:

Chang, Huan-Tsung, 1962-,

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Library	Item Barcode	Call Number	Material Type	Item Category 1	Status
Searching... 1:FBME_L	32050000000375	R857.B54 F76 2013	Open Access Book	Book	Searching... Unknown
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This book provides a comprehensive overview of the use of noble metal nanoparticles for bioimaging and biosensing. It starts with a review on the synthesis, characterization, optical properties, and bioconjugation of noble metal nanoparticles, followed by introduction of various biodetection techniques based on noble metal nanoparticles. In between these topics, microfabrication of biosensing chips and the use of microfluidics to enhance biosensing performance are discussed.

Author Notes

Lai-Kwan Chau is professor and chair of the Department of Chemistry and director of the Center for Nano Bio-Detection, National Chung Cheng University, Taiwan. He obtained his PhD from the Department of Chemistry, Iowa State University, in 1990. Prof. Chau's current research interests include biosensors, analytical chemistry, and nanomaterials.
Huan-Tsung Chang is distinguished professor and chair of the Department of Chemistry, National Taiwan University, Taiwan. He obtained his PhD from the Department of chemistry, Iowa State University, in 1994. Prof. Chang's current research interests include nanotechnology, green chemistry, biosensors, and mass spectrometry.

Hsing-Ying Lin and Ping-Ji Huang and Chen-Han Huang and Yen-Chieh Wang and Churng-Ren Chris WangChen-Sheng Yeh and Fong-Yu Cheng and Chih-Chia HuangMing-Feng Huang and Yang-Wei Lin and Huan-Tsung ChangPing-Ji Huang and Lai-Kwan ChauLai-Kwan Chau and Chang-Yue Chiang and Wei-Ting Hsu and Shin-Huei Chen and Shu-Fang ChengWei Te Wu and Guo-Hua Feng and Wen Hsin HsiehShau-Chun WangTai-Chia Chiu and Cho-Chun HuChih-Ching Huang and Yu-Shen LinYang-Wei Lin and Chi-Wei Liu and Huan-Tsung ChangLi-Lin Tay and John E. HulseYen-Hsiu Lin and Wei-Lung Tseng

Preface	p. xi
1 Synthesis and Optical Properties of Noble Metal Nanoparticles for Biodetection	p. 1
1.1 Gold Nanoparticles and Their Biomedical Applications	p. 2
1.2 Synthesis of Gold Nanoparticles	p. 3
1.3 Optical Properties of Noble Metal Nanoparticles	p. 4
1.3.1 Fluorescing Noble Metal Clusters	p. 4
1.3.2 Absorption Spectral Characteristics of Noble Metal Nanorods	p. 5
1.3.3 Scattering Spectra of Noble Metal Nanorods	p. 7
2 Bioconjugation of Noble Metal Nanoparticles and Their Applications to Biolabeling and Bioimaging	p. 11
2.1 Introduction	p. 11
2.2 Bioconjugation of Noble Metal Nanoparticles	p. 14
2.2.1 DNA Conjugation	p. 15
2.2.2 Protein, Peptide, and Antibody Conjugation	p. 16
2.2.3 Other Biomolecule Conjugation Methods	p. 18
2.3 Applications of Noble Metal Nanoparticles to Biolabeling and Bioimaging	p. 19
2.3.1 X-Ray Computed Tomography	p. 19
2.3.2 Magnetic Resonance Imaging	p. 19
2.3.3 Optical Imaging	p. 23
2.4 Conclusion and Outlook	p. 24
3 Colorimetric Bioassay Using Noble Metal Nanoparticles	p. 29
3.1 Introduction	p. 30
3.2 Synthesis of Au and Ag NPs	p. 31
3.2.1 Wet Chemical Approaches	p. 32
3.2.2 Stabilization	p. 33
3.2.3 Functionalization	p. 35
3.3 Localized Surface Plasmon Resonance of Au and Ag NPs	p. 37
3.4 Applications	p. 39
3.4.1 Crosslinking Aggregation-Based Assays	p. 39
3.4.1.1 Protein assays	p. 40
3.4.1.2 DNA and RNA assays	p. 43
3.4.1.3 Small analyte assays	p. 45
3.4.2 Non-Crosslinking Aggregation-Based Assays	p. 46
3.4.2.1 DNA assays	p. 47
3.4.2.2 Protein and small analyte assays	p. 48
3.5 Summary	p. 51
4 Slide- and Micoarray-Based Biosensors Using Noble Metal Nanoparticles	p. 57
4.1 Introduction	p. 58
4.2 Localized Surface Plasmon Resonance	p. 60
4.3 Slide-Based LSPR Biosensors	p. 61
4.4 Microarray-Based LSPR Biosensors	p. 70
4.5 Conclusions and Outlook	p. 72
5 Optical Waveguide-Based Biosensors Using Noble Metal Nanoparticles	p. 77
5.1 Introduction	p. 77
5.2 Principle of the Biosensors	p. 80
5.3 Optical Fiber-Based PPR Biosensor	p. 86
5.4 Planar Waveguide-Based PPR Biosensor	p. 93
5.5 Tubular Waveguide-Based PPR Biosensor	p. 96
5.6 Conclusions and Outlook	p. 98
6 Fabrication of Biosensor Chips	p. 103
6.1 Photolithography Process	p. 103
6.1.1 Substrate Cleaning	p. 105
6.1.2 Photoresist Selection and Application	p. 107
6.1.3 Photomask Design/Fabrication and Alignment	p. 108
6.1.4 Photoresist Exposure and Development	p. 110
6.2 Soft Lithography	p. 111
6.2.1 Lithography: Deep UV Lithography	p. 112
6.2.2 Electrodeposition: Electroplating	p. 114
6.2.3 Micro Molding: Hot-Embossing and Micro-Injection	p. 116
6.2.4 Bonding	p. 118
6.3 Fabrication of Diffraction Gratings	p. 119
6.3.1 Diamond Ruling	p. 120
6.3.2 Gray-Scale Lithography	p. 120
6.3.3 Holographic Exposure	p. 122
6.3.4 Electron-Beam Direct Writing	p. 123
6.3.5 Nanoimprint Lithography	p. 124
6.4 Manufacture of Optical Fiber Windows	p. 124
6.4.1 Etching Method	p. 127
6.4.2 Polishing Method	p. 128
6.4.3 Ultrashort High-Energy Pulse Laser Processing Method	p. 129
6.5 Conclusions and Outlook	p. 131
7 Microfluidics for Biosensor Chips	p. 135
7.1 Introduction	p. 136
7.2 Fabrication of Microfluidic Devices	p. 137
7.3 Particle Plasmon Resonance Detection in Microfluidic Devices Using Noble Metal Nanoparticles	p. 139
7.3.1 Microfluidic Devices to Facilitate PPR Detection	p. 140
7.3.2 Microfluidic Mixer to Improve PPR Detection	p. 142
7.4 Integration of Biosensing Systems Using Noble Metal Nanoparticles with Mass Spectrometer	p. 143
7.5 Fluorescence Spectroscopic Detectionin Microfluidic Devices Using Noble Metal Nanoparticles	p. 146
7.5.1 Applying Gold Nanoparticles as Quenching Acceptors to Förster Resonance Energy Transfer (FRET) Detections	p. 146
7.5.2 Using Silver Nanoparticles in Surface Plasmon Coupled Fluorescence Detection	p. 148
7.5.3 Immobilizing a Catalytic DNA Molecular Beacon on Au Nanoparticle to Detect Pb(II) Species	p. 150
7.6 Other Detection Techniques in Microfluidic Devices Using Noble Metal Nanoparticles	p. 150
7.6.1 Microfluidic Devices to Facilitate Surface-Enhanced Raman Scattering Detections	p. 150
7.6.2 Microfluidic Devices to Facilitate Thermal Lens Detections	p. 151
7.7 Conclusion	p. 152
8 Biodetection Based on Resonance Light Scattering of Noble Metal Nanoparticles	p. 157
8.1 Introduction	p. 158
8.2 Basic Theory of RLS	p. 159
8.2.1 RLS of Plasmonic NPs	p. 160
8.3 Applications of NP-Based RLS Techniques	p. 161
8.3.1 Au NPs as RLS Probes	p. 162
8.3.1.1 Small analytes	p. 162
8.3.1.2 Proteins	p. 168
8.3.1.3 DNA	p. 171
8.3.2 Ag NPs as RLS Probes	p. 174
8.3.2.1 Small analytes	p. 174
8.3.2.2 Biopolymers	p. 175
8.4 Conclusions and Outlook	p. 176
9 Photoluminescence of Gold Nanoparticles and Their Applications to Sensing and Cell Imaging	p. 181
9.1 Introduction	p. 182
9.2 Preparation and Optical Properties of Polymer-Stabilized Au NCs	p. 184
9.3 Preparation and Optical Properties of Thiol-Stabilized Au NCs	p. 188
9.4 Preparation and Optical Properties of Luminescent Au NPs	p. 194
9.5 Applications	p. 199
9.6 Conclusion	p. 205
10 Biodetection Based on Fluorescence Quenching and Surface-Enhanced Fluorescence Using Noble Metal Nanoparticles	p. 211
10.1 Introduction	p. 212
10.2 Theory	p. 214
10.2.1 Fluorescence Quenching	p. 218
10.2.2 SEF	p. 221
10.2.2.1 Surface plasmons	p. 221
10.2.2.2 Localized enhancements	p. 226
10.3 Analytical Applications	p. 230
10.3.1 Protein Immunoassays	p. 230
10.3.2 DNA Analysis	p. 235
10.3.3 Other Applications	p. 239
10.4 Conclusions and Outlook	p. 242
11 Surface-Enhanced Raman Scattering Based on Noble Metal Nanoparticles	p. 249
11.1 Introduction	p. 250
11.1.1 Electromagnetic Enhancement Mechanism	p. 251
11.1.2 Consequences of Electromagnetic Enhancement	p. 253
11.1.3 Chemical Enhancement	p. 256
11.1.4 SERS Bioanalytical Applications	p. 257
11.2 NAEB: A Novel SERS-Active Nanoparticle Assemblies	p. 259
11.3 SERS-Based Bioimaging with Multifunctional Nanoparticles	p. 262
11.4 Summary and Outlook	p. 265
12 Mass Spectrometric Bioanalysis Assisted by Noble Metal Nanoparticles	p. 271
12.1 Introduction	p. 272
12.2 Nanomaterials in LDI-MS	p. 272
12.2.1 Gold	p. 275
12.2.2 Silver and Platinum	p. 279
12.3 Nanomaterials in TOF-SIMS	p. 281
12.4 Nanomaterials in ICP-MS	p. 284
12.5 Conclusions	p. 286
Index	p. 291

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