Abeta Peptide and Alzheimer's Disease Celebrating a Century of Research

Recent advances in genetics and brain biochemistry point to the Abeta peptide as the major culprit in causing neurodegeneration in Alzheimer's Disease (AD). Abeta Peptide and Alzheimer's Disease is specifically targeted at summarizing current knowledge of the Abeta peptide and its role in AD.

Written by leaders in the industrial and academic world specializing in this rapidly moving area, the book covers fundamental biochemical studies on this peptide, the genetic impact on Abeta expression and processing, and various AD therapeutic strategies that target Abeta. Although specifically focusing on the Abeta peptide and AD, there is also some discussion on the similarity and differences of this peptide and AD with other amyloidogenic diseases, such as prion disease, Parkinsons and Huntingtons. This book will primarily be of interest to AD researchers and clinicians but also to researchers of other amyloid diseases.

David H. Small and Colin J. BarrowVictor L. Villemagne and Roberto Cappai and Kevin J. Barnham and Robert A. Cherny and Carlos Opazo and Kathy E. Novakovic and Christopher C. Rowe and Colin L. MastersRoberto Cappai and B. Elise Needham and Guiseppe D. CiccotostoPiet Eikelenboom and Willem A. van Gool and Annemieke J.M. Rozemuller and Wiep Scheper and Rob Veerhuis and Jeroen J.M. HoozemansD. Allan ButterfieldJudy Ng and Marie-Isabel Aguilar and David H. SmallLaszlo Otvos, Jr.Cyril C. Curtain and Kevin J. BarnhamJoanna M. Cordy and Benjamin WolozinSatyabrata Kar and Z. Wei and David MacTavish and Doreen Kabogo and Mee-Sook Song and Jack H. JhamandasGillian C. Gregory and Claire E. Shepherd and Glenda M. HallidayJurgen Gotz and Della C. David and Lars M. IttnerGilbert Siu and Peter Clifford and Mary Kosciuk and Venkat Venkataraman and Robert G. NageleMaria AnkarcronaJosef KarkosDwight C. German

Preface	p. v
Contributors	p. ix
1 A Brief Introduction to the History of the [Beta]-Amyloid Protein (AB) of Alzheimer's Disease	p. 1
2 The Abcentric Pathway of Alzheimer's Disease	p. 5
3 The Function of the Amyloid Precursor Protein Family	p. 37
4 The Involvement of AB in the Neuroinflammatory Response	p. 52
5 Amyloid [Beta]-Peptide(1-42), Oxidative Stress, and Alzheimer's Disease	p. 83
6 Amyloid Toxicity, Synaptic Dysfunction, and the Biochemistry of Neurodegeneration in Alzheimer's Disease	p. 93
7 A[Beta] Variants and Their Impact on Amyloid Formation and Alzheimer's Disease Progression	p. 102
8 Copper Coordination by [Beta]-Amyloid and the Neuropathology of Alzheimer's Disease	p. 125
9 Cholesterol and Alzheimer's Disease	p. 142
10 Amyloid [Beta]-Peptide and Central Cholinergic Neurons: Involvement in Normal Brain Function and Alzheimer's Disease Pathology	p. 159
11 Physiologic and Neurotoxic Properties of A[Beta] Peptides	p. 179
12 Impact of [Beta]-Amyloid on the Tau Pathology in Tau Transgenic Mouse and Tissue Culture Models	p. 198
13 Glial Cells and A[Beta] Peptides in Alzheimer's Disease Pathogenesis	p. 216
14 The Role of Presenilins in A[Beta]-Induced Cell Death in Alzheimer's Disease	p. 234
15 Immunotherapeutic Approaches to Alzheimer's Disease	p. 245
16 Mouse Models of Alzheimer's Disease	p. 259
Subject Index	p. 274
Author Index	p. 278

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