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Library | Item Barcode | Call Number | Material Type | Item Category 1 | Status |
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Searching... | 30000010132548 | RM301 U84 2005 | Open Access Book | Book | Searching... |
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Summary
Summary
Mass spectrometry (MS) is fast becoming the premier tool for analyzing various drug metabolism samples in the early phases of drug discovery and research. Introducing the newer, more powerful MS equipment and exploring new applications for using them, this book provides a state-of-the-art look at this promising field.
Using Mass Spectrometry for Drug Metabolism Studies is an excellent resource for professionals in the fields of mass spectrometry and drug metabolism. It offers current knowledge in stand-alone chapters that address specific topics thoroughly enough to be read independently, with notes and references to other chapters for further reading. The first eight chapters discuss current topics regarding the use of MS for analyzing various types of in vitro and in vivo drug metabolism samples and the final four chapters describe the latest MS technology and its uses. In each chapter, expert authors demonstrate how to apply MS to determine drug metabolism parameters. They also explain the different drug metabolism concepts and their importance.
Although there are a few books currently on the market that address this topic, they are rapidly becoming out-of-date. This book gives drug researchers and pharmacokineticists the latest information available on this important technology.
Table of Contents
Bioanalytical Assays in a Drug Discovery Environment |
Drug Metabolism In-vitro and In-vivo Results: How do these Data Support Drug Discovery? |
High Throughput Strategies for In Vitro ADME Assays: How Fast Can We Go? |
Matrix Effects: Causes and Solutions |
Direct Plasma Analysis Systems |
Acyl Glucuronides-Assays and Issues |
Utilizing Higher Mass Resolution in Quantitative Assays |
Special Requirements for Metabolite Characterization |
APPI: A New Ionization Source for LC-MS/MS Assays |
Q |