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Summary
Summary
This text discusses the functions of Process R&D (research and development), which involves the method of transforming a research synthetic procedure into a plant process and the key aspects of a synthesis that must be considered when scaling up a process. Topics consist of: basic principles of chemical development; techniques for the minimization of by-product impurities; criteria for cost-effective synthesis of enantiopure compounds by resolutions; asymmetric synthesis, and "chiral pool" strategy; synthesis for labeling substances with hydrogen or carbon isotopes; and last, licensing.
Author Notes
Oljan Repic is the author of Principles of Process Research and Chemical Development in the Pharmaceutical Industry, published by Wiley.
Reviews 1
Choice Review
Repic's title is beguiling. On the one hand, it suggests a monograph for the specialist--case studies in pharmaceutical process development; on the other, what Sandoz (Novartis) Director of Process Research and Development Repic has really done is to produce nothing less than a universal tool for synthetic chemists, wherever they may be. It offers on-the-job training for economic and environmental issues, lab safety, and plant design, while explaining why scaling up is more than multiplying a recipe by a factor. Chapter topics cover impurities, rational drug design and chirality, strategies for synthesis--a chapter that surely would have pleased the author's Harvard mentor (Robert B. Woodward)--the role of isotopes, licensing, and a nod toward the future. The hundreds of references are current through 1996. Obviously a work of love, this small monograph should be lovingly read by all who need to know about synthesis for development or basic research. And what a wealth of great resource material for making up exam questions! A wondrous work for all these reasons. Highly recommended for professional and academic libraries and those planning to enter the field. Upper-division undergraduates through professionals. L. W. Fine; Columbia University
Table of Contents
The Ideal |
Impure Thoughts |
Going All the Way |
Resolutions |
Mirrors |
Au Naturel |
Radiant |
License |
The Future |
Index |