Available:*
Library | Item Barcode | Call Number | Material Type | Item Category 1 | Status |
|---|---|---|---|---|---|
Searching... | 30000010150284 | QD96.M3 M42 2007 | Open Access Book | Book | Searching... |
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Summary
Summary
Mass spectrometry is fast becoming an indispensable field for medical professionals. The mass spectrometric analysis of metabolites and proteins promises to revolutionize medical research and clinical diagnostics. As this technology rapidly enters the medical field, practicing professionals and students need to prepare to take full advantage of its capabilities. Medical Applications of Mass Spectrometry addresses the key issues in the medical applications of mass spectrometry at the level appropriate for the intended readership. It will go a long way to help the utilization of mass spectrometry in medicine.The book comprises five parts. A general overview is followed by a description of the basic sampling and separation methods in analytical chemistry. In the second part a solid foundation in mass spectrometry and modern techniques of data analysis is presented. The third part explains how mass spectrometry is used in exploring various classes of biomolecules, including proteins and lipids. In the fourth section mass spectrometry is introduced as a diagnostic tool in clinical treatment, infectious pathogen research, neonatal diagnostics, cancer, brain and allergy research, as well as in various fields of medicine: cardiology, pulmonology, neurology, psychiatric diseases, hemato-oncology, urologic diseases, gastrointestinal diseases, gynecology and pediatrics. The fifth part covers emerging applications in biomarker discovery and in mass spectrometric imaging.
Author Notes
Professor of Chemistry, Professor of Biochemistry and Molecular Biology. Founder and Co-director, Institute for Proteomics Technology and Applications, The George Washington University.
Table of Contents
| 1 Introduction |
| 2 Basics of analytical chemistry and mass spectrometry for medical professionals |
| 3 Ethical, legal, safety and scientific aspects of medical research |
| 4 Biomedical sampling |
| 5 Separation methods |
| 6 Mass spectrometry instrumentation and techniques |
| 7 Cheminformatics: multivariate mathematical-statistical methods for data evaluation |
| 8 Mass spectrometry in proteomics |
| 9 De novo sequencing of peptides |
| 10 Protein bioinformatics |
| 11 Analysis of complex lipidomes |
| 12 Medical laboratory practice - possibilities for mass spectrometry |
| 13 Therapeutic drug monitoring |
| 14 Mass spectrometry of infectious pathogens |
| 15 Proteomics of viruses and their host partners |
| 16 Neonatal diagnostics |
| 17 Application of mass spectrometry in oncology |
| 18 Application of mass spectrometry in brain research: neurotransmitters, neuropeptides and brain proteins |
| 19 The human pituitary proteome: clinical applications |
| 20 Mass spectrometry of proteinous allergens inducing human diseases |
| 21 Mass spectrometry in clinical treatment |
| 22 Biomarker discovery |
| 23 Molecular imaging by mass spectrometry |
| 24 Brief outlook |
