Sonke SvensonAnthony J. McHugh and Jessica R. DesNoyer and Chandrashekar RamanJorge Heller and John BarrStephen K. Dordunoo and William C. Vincek and Mahesh Chaubal and Zhong Zhao and Rena Lapidus and Randall Hoover and Wenbin DangP. Somasundaran and Fang Liu and Soma Chakraborty and Carl C. Gryte and Namita Deo and T. SomasundaranNobuyuki Morimoto and Shin-ichiro M. Nomura and Naomi Miyazawa and Kazunari AkiyoshiSarvesh K. Agrawal and Heidi A. Sardhina and Khaled A. Aamer and Naomi Sanabria-DeLong and Surita R. Bhatia and Gregory N. TewZhiyong Gu and Paschalis AlexandridisE. Alexandre and K. Boudjema and B. Schmitt and J. Cinqualbre and D. Jaeck and P. J. LutzRamesh Dandu, Zaki Megeed, Mohamed Haider, Joseph Cappello and Hamidreza GhandehariBrent Weinberg and Feng Qian and Jinming GaoJianwei Li and Jeremy J. MassoK. L. Andrew Chan and Sergei G. KazarianJorg C. TillerB. Y. Shekunov and P. Chattopadhyay and J. SeitzingerJ. Richard and F. Deschamps and A. M. De Conti and O. ThomasFenghui Niu and Katherine F. Roby and Roger A. Rajewski and Charles Decedue and Bala SubramaniamBrian K. Johnson and Walid Saad and Robert K. Prud'hommeE. J. Elder and J. E. Hitt and T. L. Rogers and C. J. Tucker and S. Saghir and G. B. Kupperblatt and S. Svenson and J. C. EvansKirk A. Overhoff and Keith P. Johnston and Robert O. Williams IIIJ. C. Evans and B. D. Scherzer and C. D. Tocco and G. B. Kupperblatt and J. N. Becker and D. L. Wilson and S. Saghir and E. J. ElderLarry Brown and Yuanxi Qin and Kenneth Hogeland and John McGeehan and Kathy Mason and Travis Jeannotte and Robert Fortier and Eric MooreYourong Fu and Seong Hoon Jeong and Jacqueline Callihan and Jeanny Kim and Kinam Park

Preface	p. xi
Overview
1 Advances in Polymeric Matrices and Drug Particle Engineering	p. 2
Polymeric Matrices
2 Injectable Drug Delivery Based on Polymer Solutions: Experiment and Modeling	p. 14
3 Poly(Ortho esters): Some Recent Developments	p. 29
4 Paclitaxel Delivery from Novel Polyphosphoesters: From Concept to Clinical Trials	p. 44
5 Novel Nanogels for Drug Binding and Delivery	p. 69
6 Nanogel Engineered Designs for Polymeric Drug Delivery	p. 88
7 Triblock Plla-Peo-Plla Hydrogels: Structure and Mechanical Properties	p. 102
8 Equilibrium and Kinetics of Drying and Swelling of Poloxamer Hydrogels	p. 120
9 Poly(Ethylene oxide) Hydrogels: Valuable Candidates for an Artificial Pancreas?	p. 135
10 Silk-Elastinlike Hydrogels: Thermal Characterization and Gene Delivery	p. 150
11 Development and Characterization of Dual-Release Poly(d,l-lactide-co-glycolide) Millirods for Tumor Treatment	p. 169
12 Prediction of Drug Solubility in Adhesive Matrix for Transdermal Drug Delivery Based on a Solvation Parameter Model	p. 186
13 Dissolution of Solid Dispersions of Ibuprofen Studied by Fourier Transform Infrared Imaging	p. 203
14 Silver-Based Antimicrobial Coatings	p. 215
Engineered Drug Particles
15 Engineering of Composite Particles for Drug Delivery Using Supercritical Fluid Technology	p. 234
16 Using a Supercritical Fluid-Based Process: Application to Injectable Sustained-Release Formulations of Biomolecules	p. 250
17 Paclitaxel Nanoparticles: Production Using Compressed CO 2 as Antisolvent: Characterization and Animal Model Studies	p. 262
18 Nanoprecipitation of Pharmaceuticals Using Mixing and Block Copolymer Stabilization	p. 278
19 Particle Engineering of Poorly Water Soluble Drugs by Controlled Precipitation	p. 292
20 Improvement of Dissolution Rate of Poorly Water Soluble Drugs Using a New Particle Engineering Process: Spray Freezing into Liquid	p. 305
21 Preparation of Nanostructured Particles of Poorly Water Soluble Drugs via a Novel Ultrarapid Freezing Technology	p. 320
22 Water-Soluble Polymer Formation of Monodispersed Insulin Microspheres	p. 329
23 Preparation of Fast-Dissolving Tablets Based on Mannose	p. 340
Author Index	p. 353
Subject Index	p. 355