Ion Channels as Therapeutic Targets Part A

Title:

Series:

Advances in protein chemistry and structural biology ; volume 103

Physical Description:

xvi, 386 pages : illustrations ; 24 cm.

ISBN:

9780128047941

Subject Term:

Ion channels

Added Author:

Donev, Rossen,

Available:*

Library	Item Barcode	Call Number	Material Type	Item Category 1	Status
Searching... PSZ JB	30000010343598	QD431 I66 2016	Open Access Book	Book	Searching... Unknown

Ion Channels as Therapeutic Targets is the latest volume in the popular Advances in Protein Chemistry and Structural Biology series, an essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins, with each thematically organized volume guest edited by leading experts in a broad range of protein-related topics.

Author Notes

Rossen Donev received his PhD degree in 1999 from the Institute of Molecular Biology, Bulgarian Academy of Sciences. He did postdoctoral training at Imperial Cancer Research Fund, UK (renamed after the merger with Cancer Research Campaign to Cancer Research UK, London Research Institute) and Cardiff University. In 2010 Dr. Donev was appointed Lecturer in Swansea University. Currently he is Director of Biomed Consult Ltd, UK. His major research interests include signalling pathways involved in neuropsychiatric disorders and tumour escape from the immune system, and development of therapeutic strategies for treatment. He has published more than 50 research papers, has chaired scientific meetings in Molecular Medicine and given plenary talks at Attention Deficit/Hyperactivity Disorder meetings. Rossen Donev has consulted on projects related to development of treatments for neurodevelopmental disorders and cancer therapies. He serves as Editor-in-Chief of the Advances in Protein Chemistry and Structural Biology and on editorial board of several other journals.

Yan-Lin Fu and Ya-Juan Wang and Ting-Wei MuRoman V. Frolov and Matti WeckströmPravir Kumar and Dhiraj Kumar and Saurabh Kumar Jha and Niraj Kumar Jha and Rashmi K. AmbastaBeatrice Mihaela Radu and Adela Banciu and Daniel Dumitru Banciu and Mihai RaduGislaine Z. Réus and Helena M. Abelaira and Talita Tuon and Stephanie E. Titus and Zuleide M. Ignácio and Ana Lúcia S. Rodrigues and Joao QuevedoKevin Lee and Lucy Goodman and Chantelle Fourie and Susan Schenk and Beulah Leitch and Johanna M. MontgomeryJohannes Weller and Christian Steinhäuser and Gerald SeifertHongmei Wu and Xu Chen and Jinke Cheng and Yitao Qi

Contributors	p. ix
Preface	p. xiii
1 Proteostasis Maintenance of Cys-Loop Receptors	p. 1
1 Introduction	p. 2
2 Folding, Assembly, and Degradation of Cys-Loop Receptors in the ER	p. 5
3 Trafficking of Cys-Loop Receptors from ER to Golgi and to Plasma Membrane	p. 10
4 Protein Quality Control of Cys-Loop Receptors on the Plasma Membrane	p. 11
5 Other Regulations of Cys-Loop Receptors	p. 13
6 Disease and Therapy	p. 15
References	p. 16
2 Harnessing the Flow of Excitation; TRP, Voltage-Gated Na + , and Voltage-Gated Ca 2+ Channels in Contemporary Medicine	p. 25
1 Introduction	p. 26
2 TRP Channels	p. 31
3 Voltage-Gated Na + Channels	p. 36
4 Voltage-Gated Ca 2+ Channels	p. 47
5 Channelopathies of TRP, Nav, and Cav Channels	p. 60
6 Harnessing the Flow of Excitation in Neural Circuits	p. 77
7 Conclusion and Perspectives	p. 80
Acknowledgments	p. 81
References	p. 81
3 Ion Channels in Neurological Disorders	p. 97
1 Introduction	p. 98
2 Aberrant Channels in NDDs	p. 103
3 Therapeutics Approach to Correct Altered Channel Function in NDDs	p. 121
4 Conclusion	p. 125
Acknowledgments	p. 125
Glossary	p. 126
References	p. 126
4 Acid-Sensing Ion Channels as Potential Pharmacological Targets in Peripheral and Central Nervous System Diseases	p. 137
1 Acid-Sensing Ion Channels: General View	p. 138
2 PNS Pathologies: ASICs as a Pharmacological Target	p. 143
3 CNS Pathologies: ASICs as a Pharmacological Target	p. 147
4 Conclusions	p. 157
Acknowledgments	p. 157
References	p. 158
5 Glutamatergic NMDA Receptor as Therapeutic Target for Depression	p. 169
1 Introduction	p. 170
2 Glutamatergic System	p. 171
3 NMDA Receptor Binding and Modulators with Antidepressant Properties	p. 174
4 Conclusion	p. 187
Acknowledgments	p. 188
References	p. 189
6 AMPA Receptors as Therapeutic Targets for Neurological Disorders	p. 203
1 AMPA Receptor Structure and Function	p. 205
2 Synaptic Plasticity and AMPA Receptor Dynamics	p. 207
3 AMPA Receptor Interactions with Postsynaptic Density Proteins	p. 215
4 AMPA Receptors in Neurodegenerative Diseases	p. 223
5 AMPA Receptors and ASD	p. 228
6 AMPA Receptors in the Treatment of Drug Addiction	p. 231
7 AMPA Receptors and Epilepsy	p. 233
8 Translating Data from Animal Models to the Human Brain	p. 236
9 Conclusions and Future Directions	p. 237
References	p. 237
7 pH-Sensitive K + Currents and Properties of K 2 P Channels in Murine Hippocampai Astrocytes	p. 263
1 Introduction	p. 264
2 Materials and Methods	p. 266
3 Results	p. 273
4 Discussion	p. 282
Acknowledgment	p. 289
References	p. 289
8 SUMOylation and Potassium Channels: Links to Epilepsy and Sudden Death	p. 295
1 Introduction	p. 296
2 SUMOylation and De-SUMOylation Machinery	p. 297
3 SUMOylation and Potassium Ion Channels	p. 302
4 Role of SUMOylation in Epilepsy and Sudden Death	p. 307
5 Conclusions and Outlook	p. 312
Acknowledgment	p. 313
References	p. 313
Author Index	p. 323
Subject Index	p. 377

Available:*

On Order

Summary

Summary

Author Notes

Table of Contents