New trends in cancer for the 21st century

It is difficult to imagine anyone who has not heard of cancer. This disease can affect families, friends or any one of us at any time in our lives. Every year nearly 3 million Europeans are diagnosed with cancer, leading to around 800,000 deaths per year. These deaths occur not only in aging populations, but also in children and adults who are in the most active period of their lives. This represents a tremendous problem that cannot be ignored by politicians or citizens. Fortunately, there is a constantly growing awareness that although cancer is a problem to be dealt with by clinicians, it should also be the concern of everyone. This volume contains the lectures held at the International Symposium on Cancer "New Trends in Cancer for the 21st Century". Fundamental researchers, politicians and representatives from patient coalitions share here their knowledge and interests as well as their concerns and experiences. Not only do these papers provide state-of-the-art information on cancer, they are also an opportunity to look at the problem from different points of view. It can be encouraging to realise that we are not alone in this fight.

P. Picci and K. Scotlandi and M. Serra and A. RizziK. ScotlandiB. PerbalJ. Ban and C. Siligan and M. Kreppel and D. Aryee and H. KovarH. Vauhkonen and S. Savola and S. Kaur and M.L. Larramendy and S. KnuutilaP.H.J. Riegman and M.H.A. Oomen and W.N.M. Dinjens and J.W. Oosterhuis and K.H. Lam and A. Spatz and C. Ratcliffe and K. Knox and R. Mager and D. Kerr and F. Pezzella and B. van Damme and M. van de Vijver and H. van Boven and M.M. Morente and S. Alonso and D. Kerjaschki and J. Pammer and J.A. Lopez-Guerrero and A. Llombart-Bosch and A. Carbone and A. Gloghini and I. Teodorovic and M. Isabelle and A. Passioukov and S. Lejeune and P. Therasse and E.-B. van VeenM. Isabelle and I. Teodorovic and J.W. Oosterhuis and P.H.J. RiegmanU. RingborgJ. CostaM. MiettinenH. Hofler and R. Langer and K. Ott and G. KellerD. Lopez-TerradaM. MalumbresD. Ramos and C.M. AldazJ.K. Habermann and U.J. Roblick and M. Upender and T. Ried and G. AuerL. Holmquist and T. Lofstedt and S. PahlmanJ.L. Ramirez and M.F. Salazar and J. Gupta and J.M. Sanchez and M. Taron and M. Sanchez-Ronco and Vicente Alberola and R. da las PenasH.J. LenzL. PusztaiE. Diaz-RubioA. KjaerB. Celda and D. Monleon and M.C. Martinez-Bisbal and V. Esteve and B. Martinez-Granados and E. Pinero and R. Ferrer and J. Piquer and L. Marti-Bonmati and J. CerveraG. Storme and D. Verellen and G. Soete and N. Linthout and J. Van de Steene and M. Voordeckers and V. Vinh-Hung and K. Tournel and D. Van den BergeB. Rubio-Viqueira and M. HidalgoJ. AlbanellE. Barbera Guillem and J.W. SampselA. Llombart Cussac

Preface	p. xi
List of Contributors	p. xvii
1 Prognostic and Therapeutic Targets in the Ewing's Family of Tumors (PROTHETS)	p. 1
2 Targeted Therapies in Ewing's Sarcoma	p. 13
3 The CCN3 Protein and Cancer	p. 23
4 Ews-Fli1 in Ewing's Sarcoma: Real Targets and Collateral Damage	p. 41
5 Molecular Karyotyping in Sarcoma Diagnostics and Research	p. 53
6 TuBaFrost: European Virtual Tumor Tissue Bankin	p. 65
7 Virtual Microscopy in Virtual Tumor Banking	p. 75
8 Harmonizing Cancer Control in Europe	p. 87
9 The Diagnosis of Cancer: "From H&E to Molecular Diagnosis and Back"	p. 95
10 From Morphological to Molecular Diagnosis of Soft Tissue Tumors	p. 99
11 Prediction of Response to Neoadjuvant Chemotherapy in Carcinomas of the Upper Gastrointestinal Tract	p. 115
12 Integrating the Diagnosis of Childhood Malignancies	p. 121
13 Preclinical Models for Cell Cycle-Targeted Therapies	p. 139
14 WWOX, a Chromosomal Fragile Site Gene and its Role in Cancer	p. 149
15 From Genome to Proteome in Tumor Profiling: Molecular Events in Colorectal Cancer Genesis	p. 161
16 Effect of Hypoxia on the Tumor Phenotype: The Neuroblastoma and Breast Cancer Models	p. 179
17 Methylation Patterns and Chemosensitivity in NSCLC	p. 195
18 Pharmacogenomics and Colorectal Cancer	p. 211
19 Development of Pharmacogenomic Predictors for Preoperative Chemotherapy of Breast Cancer	p. 233
20 Vascular Endothelial Growth Factor Inhibitors in Colon Cancer	p. 251
21 Molecular Imaging of Cancer Using PET and SPECT	p. 277
22 MRS as Endogenous Molecular Imaging for Brain and Prostate Tumors: FP6 Project "eTumor"	p. 285
23 From Linac to Tomotherapy: New Possibilities for Cure?	p. 303
24 Targeting mTOR for Cancer Treatment	p. 309
25 Dual/Pan-Her Tyrosine Kinase Inhibitors: Focus in Breast Cancer	p. 329
26 AntiTumor-Associated Antigens IGGS: Dual Positive and Negative Potential Effects for Cancer Therapy	p. 341
27 Synergistic Molecular Mechanisms in Hormone-Sensitive Breast Cancer	p. 375
Index	p. 387

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