Available:*
Library | Item Barcode | Call Number | Material Type | Item Category 1 | Status |
|---|---|---|---|---|---|
Searching... | 30000010101658 | RS199.5 W36 2005 | Open Access Book | Book | Searching... |
On Order
Summary
Summary
An indispensable tool for those working at the front lines of new drug development
Written for busy professionals at the forefront of new drug development, Drug Delivery gets readers quickly up to speed on both the principles and latest applications in the increasingly important field of drug delivery.
Recent developments in such areas as combinatorial chemistry, proteomics, and genomics have revolutionized researchers' ability to rapidly identify and synthesize new pharmacological compounds. However, delivery-related properties remain a significant reason for clinical trial failures.
Bringing together contributions by leading international experts, Drug Delivery covers the entire field in a systematic but concise way. It begins with an in-depth review of key fundamentals, such as physiochemical and biological barriers; drug delivery pathways; metabolism; drug formulation; pharmacokinetic and pharmacodynamic issues; and more. The remainder of the book is devoted to the systematic examination-including overviews, timely examples, and extensive references-of a host of specific subjects, including:
* Receptor-mediated drug delivery
* Prodrug delivery approaches
* Oral protein and peptide drug delivery
* Gene therapy and gene delivery
* Ultrasound-mediated drug delivery
* Polycationic peptides and proteins in drug delivery
* Pulmonary drug delivery
* Antibody-directed drug delivery
* Efflux transporters in drug excretion
* Intellectual property issues in drug delivery
Author Notes
BINGHE WANG, PhD, is a professor and Georgia Research Alliance Eminent Scholar in Drug Discovery, and Georgia Cancer Coalition Distinguished Cancer Scientist in the Department of Chemistry, Georgia State University. He is Editor in Chief of Medicinal Research Reviews and a member of the Long-Range Planning Committee of the American Chemical Society, Division of Medicinal Chemistry.
TERUNA SIAHAAN, PhD, is a professor in the Pharmaceutical Chemistry Department, University of Kansas, and a Fellow of the American Association of Pharmaceutical Scientists.
RICHARD A. SOLTERO, PhD, President of PharmaDirections, Inc., is an executive- level scientist with extensive experience managing multisite and multinational pharmaceutical and biotechnology labs.
Table of Contents
| Preface |
| List of Contributors |
| 1 Factors that Impact the Developability of Drug Candidates-An OverviewChao Han and Binghe Wang |
| 2 Chemical, Biochemical, and Physiological Barriers to Oral Drug DeliveryTeruna Siahaan |
| 3 Pathways for Drug Delivery to the Central Nervous SystemYan Zhang and Donald W. Miller |
| 4 Physiochemical Properties, Formulation and Drug DeliveryE. Munson |
| 5 Targeted Bioavailability: A Fresh Look at Pharmacokinetic and Pharmacodynamic Issues in Drug DeliveryWilliam F. Elmquist |
| 6 Pre-Systemic and First-pass MetabolismW. Griffith Humphreys |
| 7 Cell Culture Models for Drug Transport StudiesD. Nedra Karunaratne and Peter S. Silverstein and Veena Vasabdabi and Amber M. Young and Erik Rytting and Bradley Yops and Kenneth L. Audus |
| 8 Prodrug Approaches to Drug DeliveryLongqin Hu |
| 9 Receptor-Mediated Drug DeliveryChirstopher P. Leamon and Philip S. Low |
| 10 Oral Protein and Peptide Drug DeliveryRick Soltero |
| 11 Metabolic Activation and Drug TargetingXiangming Guan |
| 12 Ultrasound Mediated Drug DeliveryKa-yun Ng' and Terry O. Matsunaga |
| 13 Polycationic Peptides and Proteins in Drug Delivery: Focus on Non-Classical TransportLisa A. Kueltzo and C. Russell Middaugh |
| 14 Gene Therapy and Gene DeliveryNaoki Kobayashi and Makiya Nishikawa and Yoshinobu Takakura |
| 15 Parenteral Formulations for Peptide and Protein Delivery, and Monoclone Antibody DrugsJohn Bontempo |
| 16 Pulmonary Drug Delivery - Pharmaceutical Chemistry and Aerosol TechnologyAnthony J. Hickey |
| 17 Antibody-Directed Drug DeliveryHerve Le Calvez and John Mountzouris and Kosi Gramatikoff and Fang Fang |
| 18 Efflux Transporters in Drug ExcretionShuzhong Zhang and Marilyn E. Morris |
| 19 Liposome as Drug Delivery VehiclesGuijun Wang |
| 20 Regulatory and IP Issues in Drug Delivery ResearchShihong Nicolaou |
| Index |
