Basement membranes : cell and molecular biology

Title:

Series:

Current topics in membranes ; v. 56

Publication Information:

Amsterdam : Elsevier, 2005

ISBN:

9780121533564

Subject Term:

Membrane, Basement

Membranes (Biology)

Molecular biology

Added Author:

Kefalides, Nicholas A.

Borel, Jacques P.

Available:*

Library	Item Barcode	Call Number	Material Type	Item Category 1	Status
Searching... PSZ JB	30000004581967	QH601 B37 2005	Open Access Book	Book	Searching... Unknown

Basement Membranes: Cell and Molecular Biology brings together the most important research developments of the past 45 years that have enriched our knowledge and contributed to a better understanding of the biochemistry and cell and molecular biology of basement membranes. It describes the studies that shed light on the ultrastructural organization, the biosynthesis of the macromolecular components, their functions in embryonic development and differentiation, and in the mature state. A major portion of the book is devoted to the description of the genes that regulate the expression of the various structural macromolecules.

Dedication	p. v
Acknowledgments	p. xi
Preface	p. xiii
Previous Volumes in Series	p. xv
Part I Biology of Basement Membranes
Chapter 1 The Early Years of Basement Membrane Research
I Introduction	p. 3
II Tissue Localization	p. 4
III Morphology	p. 5
IV Immunochemical Properties	p. 6
V Chemical Composition	p. 7
VI Macromolecular Components	p. 8
VII The Story Continues	p. 13
References	p. 14
Chapter 2 Morphology and Ultrastructure of Basement Membranes
I Introduction	p. 19
II Capillaries	p. 20
III Kidney	p. 22
IV Skin	p. 27
V The Pulmonary Alveolar Wall	p. 30
VI The Eye	p. 31
VII The Choroid Plexus of the Brain	p. 36
References	p. 41
Chapter 3 Basement Membranes in Development
I Introduction	p. 43
II The Role of Laminin-1	p. 45
III The Role of Entactin/Nidogen	p. 52
IV The Role of Collagen Type IV	p. 53
V The Role of Proteoglycans	p. 63
References	p. 70
Chapter 4 Functions of Basement Membranes
I Introduction	p. 79
II Functions of the Renal Glomerulus	p. 81
III Functions of the Renal Tubules	p. 89
IV Functions of the Alveolar-Capillary Membrane	p. 90
V Functions of the Choroid Plexus	p. 96
VI Functions of the Intestinal Mucosa	p. 99
VII Functions of the Cutaneous Basement Membrane Zone	p. 101
VIII Functions of the Ocular Basement Membranes	p. 103
References	p. 106
Part II Chemistry and Metabolism of Basement Membrane
Chapter 5 Structural Macromolecules: Type IV Collagen
I Introduction	p. 115
II Type IV Collagen: Structure and Genes	p. 116
References	p. 140
Chapter 6 Structural Macromolecules: Laminins, Entactin/Nidogen, and Proteoglycans (Perlecan, Agrin)
I Structure of Laminins	p. 147
II Nidogen/Entactin: Structure and Genes	p. 169
III Proteoglycans: Structure and Genes	p. 174
References	p. 181
Chapter 7 Minor Proteins of Basement Membranes, Minor Collagens of the Basement Membrane Zone
I Minor Proteins of Basement Membranes	p. 199
II Minor Collagens of the Basement Membrane Zone	p. 203
References	p. 213
Chapter 8 Biosyntheses of Basement Membrane Macromolecules
I Transcription and Translation	p. 226
II Posttranslational Modifications	p. 234
III Binding of Glucosyl or Glycosaminoglycan Chains to Protein Cores	p. 237
IV Association of Polypeptide Chains	p. 239
V Gene Expression and Control	p. 241
References	p. 249
Chapter 9 Internal Organization of Basement Membranes
I The Laminin Polymer	p. 266
II The Binding of Entactin/Nidogen to Laminin	p. 268
III The Type IV Collagen Polymer	p. 271
IV The Binding of Entactin/Nidogen to Type IV Collagen	p. 275
V Other Interactions	p. 276
VI General Architecture of the Basement Membrane Complex	p. 277
References	p. 279
Chapter 10 Contacts of Basement Membrane Molecules with Cell Membranes
I Interactions of Laminin Isoforms with Cells	p. 287
II Entactin/Nidogen Binding to Cells	p. 303
III Binding of Collagen Type IV to Cells	p. 304
IV Binding of Basement Membrane Proteoglycans to Cells	p. 305
References	p. 307
Part III Alterations of Basement Membranes in Pathologic and Physiologic States
Chapter 11 Immune-Mediated Diseases Involving Basement Membranes
I Introduction	p. 323
II Goodpasture Syndrome	p. 325
III Membranous Nephropathy	p. 333
IV Postinfectious Glomerulonephritis	p. 340
References	p. 344
Chapter 12 Genetically Mediated and Acquired Basement Membrane Disorders
I Introduction	p. 353
II Alport Syndrome	p. 353
III Epidermolysis Bullosa	p. 358
IV Diabetes Mellitus	p. 364
References	p. 372
Chapter 13 Novel Biological Properties of Peptides Arising from Basement Membrane Proteins
I Matrikines and Matricryptines	p. 382
II Matrikines Formed from Type IV Collagen	p. 385
III Effects of Matrikines Derived from Collagens XV and XVIII	p. 394
IV Effects of the Matrikines Formed from Laminin and from Other Proteins, and Proteoglycans of the Basement Membrane	p. 398
V Conclusion	p. 400
References	p. 401
Index	p. 413

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