Viral nanoparticles : tools for materials science & biomedicine

Library	Item Barcode	Call Number	Material Type	Item Category 1	Status
Searching... 1:FBME_L	32050000000389	QR360 S74 2011	Open Access Book	Book	Searching... Unknown
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This book overviews the applications of viral nanoparticles (VNPs) in areas ranging from materials science to biomedicine. It summarizes the many different VNP building blocks and describes chemistries that allow one to attach, entrap, or display functionalities on VNPs. The book outlines the strategies for the construction of 1-, 2-, and 3-D arrays, highlights the achievements in utilizing VNPs as tools for novel biosensors and nanoelectronic devices, and describes efforts in designing VNPs for biomedical applications, including their use as gene delivery vectors, novel vaccines, imaging modalities, and applications in targeted therapeutics.

Author Notes

Nicole F. Steinmetz is Assistant Professor of Biomedical Engineering at Case Western Reserve University, Cleveland, OH. Her major area of professional interest lies with the application of complex viral nanoparticle (VNP) formulations for biomedicine and materials science. Dr. Steinmets is a 2009 recipient of the NIH/NIBIB Pathway to Independence Grant (K99/R00), a previous American Heart Association Post-doctoral Fellow, former Marie Curie EST Fellow, and winner of the Bryan Harrison Prize (2006) and of the Biosciences Federation Science Communication Award (2007). Dr. Steinmetz received her diploma (equivalent to master's) with honors in molecular biology from RWTH-Aachen (Germany) and her PhD in the field of nanobiotechnology in 2007 from the John Innes Centre (UK).
Marianne Manchester specializes in novel virus-based nanotechnologies for tumor targeting and vaccine development, and since 2002 she has led National Institutes of Health-sponsored programs in these areas. She is currently Professor at the Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, following 11 years on the faculty of the Scripps Research Institute. Dr. Manchester designs virus-based structural scaffolds for antigen presentation that promote whole antigen display and protective immunity and has authored more than 60 peer-reviewed scientific publications and 4 patents or patents pending.

Preface	p. vii
Chapter 1 An Introduction to VNPs and Nanotechnology	p. 1
Chapter 2 Overview of the Manifold VNPs Used in Nanotechnology	p. 13
Chapter 3 Production of VNPs, VLPs, and Chimeras	p. 49
Chapter 4 The Art of Bioconjugation: Functionalization of VNPs	p. 75
Chapter 5 Encapsulating Materials within VNPs	p. 123
Chapter 6 VNPs as Templates for Materials Synthesis	p. 145
Chapter 7 Playing "Nano-Lego": VNPs as Building Blocks for the Construction of Multi-Dimensional Arrays	p. 171
Chapter 8 VNPs as Tools for Nanomedicine	p. 207
Chapter 9 Summary and Outlook	p. 247
Appendix A p. 249
Appendix B p. 250
Appendix C p. 251
Appendix D p. 255
Appendix E p. 264
Index	p. 267

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Table of Contents