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Library | Item Barcode | Call Number | Material Type | Item Category 1 | Status |
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Searching... | 30000010195148 | QP143.7 D54 2009 | Open Access Book | Book | Searching... |
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Summary
Summary
A consequence of rapid progress in the science of nutrigenomics and nutrigenetics is the substantial accumulation of data covering nutrienal modulation of gene expression at the cellular and subcellular levels. Current research is increasingly focused on the role of nutrition and diet in modifying oxidative damage in the progression of disease. Dietary Modulation of Cell Signaling Pathways reviews some of these findings, focusing on nutrient-gene interactions with particular emphasis on the intracellular signaling network.
Explore a Pivotal Function for Maintaining Homeostasis
The book addresses the dietary modulation of particular gene expression systems and highlights the underlying molecular and cellular mechanisms that involve upstream signaling molecules, such as kinases and transcription factors in the context of their therapeutic potential. It describes nutrients' actions on the activation of an antioxidant and inflammatory transcription factor and the induction of their target gene expression.
Provides a Mechanistic Understanding of the Action of Dietary Components
Comprehensively covering dietary modulation of cell signaling, leading experts provide information on state-of-the-art research in their own specialty. For those working in the fields of dietary components, molecular mechanisms, and health benefits, this book presents a useful tool for mechanistic understanding of the action of dietary components.
Table of Contents
Series Preface | p. xi |
Preface | p. xv |
Editors | p. xvii |
Contributors | p. xix |
Chapter 1 Intracellular Signaling Molecules as Targets of Selected Dietary Chemopreventive Agents | p. 1 |
Chapter 2 Modulation of Cell Signal Transduction by Tea and Ginger | p. 45 |
Chapter 3 Modulation of MAPK Pathways by Food Phytochemicals: Risks and Benefits | p. 75 |
Chapter 4 Turmeric as Cure-Cumin: Promises, Problems, and Solutions | p. 91 |
Chapter 5 Flavanols and NF-[kappa]B Activation: Relevance for Inflammation and Associated Diseases | p. 137 |
Chapter 6 Regulation of Inflammation, Redox, and Glucocorticoid Signaling by Dietary Polyphenols | p. 153 |
Chapter 7 Dietary Factors in Food: Induction of Nrf2-Mediated Defense Genes in Normal Cells versus Inhibition of Cell Growth Genes in Tumor Cells | p. 189 |
Chapter 8 The Isothiocyanate Sulforaphane Induces the Phase 2 Response by Signaling of the Keap1-Nrf2-ARE Pathway: Implications for Dietary Protection against Cancer | p. 205 |
Chapter 9 Nutritional Redox Homeostasis and Cellular Stress Response: Differential Role of Homocysteine and Acetylcarnitine | p. 229 |
Chapter 10 Dietary Factors in the Regulation of Selenoprotein Biosynthesis | p. 251 |
Chapter 11 Regulation of Signaling Pathways by Selenium in Cancer | p. 273 |
Chapter 12 Modulation of Gene Expression by Dietary Carotenoids and Retinoids: Role in Cancer Prevention | p. 315 |
Chapter 13 Targeting the Epigenome with Dietary Agents | p. 337 |
Chapter 14 Effects of Astaxanthin on Microarray Profiling of Gene Expression Patterns of Glomerular Cells in Diabetic Mice | p. 371 |
Chapter 15 Insulin Resistance and Inflammatory Signaling Pathways Modulated by High-Fat Diet | p. 385 |
Chapter 16 Molecular Effect of Complex Food Matrices on Endothelial Functions-A Complex Issue to Study: The Case of Wine | p. 417 |
Chapter 17 Role of Oxidative Stress in [beta]-Thalassemia and the Antioxidative Effect of Fermented Papaya Preparation | p. 431 |
Chapter 18 Ginkgo Biloba Leaf Extract (EGb 761) Modulates Cell Signaling Associated with Amyloid Beta Oligomers in Alzheimer's Disease | p. 445 |
Index | p. 465 |