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Cover image for Dietary modulation of cell signaling pathways
Title:
Dietary modulation of cell signaling pathways
Publication Information:
Boca Raton, FL : CRC Press, 2009
Physical Description:
xxii, 477 p. : ill. (some col.) ; 24 cm.
ISBN:
9780849381485
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30000010195148 QP143.7 D54 2009 Open Access Book Book
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Summary

Summary

A consequence of rapid progress in the science of nutrigenomics and nutrigenetics is the substantial accumulation of data covering nutrienal modulation of gene expression at the cellular and subcellular levels. Current research is increasingly focused on the role of nutrition and diet in modifying oxidative damage in the progression of disease. Dietary Modulation of Cell Signaling Pathways reviews some of these findings, focusing on nutrient-gene interactions with particular emphasis on the intracellular signaling network.

Explore a Pivotal Function for Maintaining Homeostasis

The book addresses the dietary modulation of particular gene expression systems and highlights the underlying molecular and cellular mechanisms that involve upstream signaling molecules, such as kinases and transcription factors in the context of their therapeutic potential. It describes nutrients' actions on the activation of an antioxidant and inflammatory transcription factor and the induction of their target gene expression.

Provides a Mechanistic Understanding of the Action of Dietary Components

Comprehensively covering dietary modulation of cell signaling, leading experts provide information on state-of-the-art research in their own specialty. For those working in the fields of dietary components, molecular mechanisms, and health benefits, this book presents a useful tool for mechanistic understanding of the action of dietary components.


Table of Contents

Joydeb Kumar Kundu and Hye-Kyung Na and Young-Joon SurhAnn M. Bode and Zigang DongAkira Murakami and Yasutaka Ikeda and Hajime OhigashiShishir Shishodia and Krishna Misra and Bharat B. AggarwalCesar G. Fraga and Patricia I. OteizaIrfan Rahman and Saibal K. BiswasAuemduan Prawan and Ah-Ng Tony KongAlbena T. Dinkova-KostovaVittorio Calabrese and Riccardo Ientile and Carolin Cornelius and Marina Scalia and Maria T. Cambria and Bernardo Ventimiglia and Giovanni Pennisi and Cesare Mancuso and D. Allan ButterfieldRegina Brigelius-Flohe and Antje BanningJunxuan Lu and Hongbo Hu and Cheng JiangJohn S. BertramBarbara Delage and Roderick H. DashwoodYuji Naito and Satomi Akagiri and Toshikazu YoshikawaTaesun Park and Seung-Jin KimRaffaella Canali and Fabio VirgiliEitan Fibach and Ada Goldfarb and Johnny AmerYuan Luo
Series Prefacep. xi
Prefacep. xv
Editorsp. xvii
Contributorsp. xix
Chapter 1 Intracellular Signaling Molecules as Targets of Selected Dietary Chemopreventive Agentsp. 1
Chapter 2 Modulation of Cell Signal Transduction by Tea and Gingerp. 45
Chapter 3 Modulation of MAPK Pathways by Food Phytochemicals: Risks and Benefitsp. 75
Chapter 4 Turmeric as Cure-Cumin: Promises, Problems, and Solutionsp. 91
Chapter 5 Flavanols and NF-[kappa]B Activation: Relevance for Inflammation and Associated Diseasesp. 137
Chapter 6 Regulation of Inflammation, Redox, and Glucocorticoid Signaling by Dietary Polyphenolsp. 153
Chapter 7 Dietary Factors in Food: Induction of Nrf2-Mediated Defense Genes in Normal Cells versus Inhibition of Cell Growth Genes in Tumor Cellsp. 189
Chapter 8 The Isothiocyanate Sulforaphane Induces the Phase 2 Response by Signaling of the Keap1-Nrf2-ARE Pathway: Implications for Dietary Protection against Cancerp. 205
Chapter 9 Nutritional Redox Homeostasis and Cellular Stress Response: Differential Role of Homocysteine and Acetylcarnitinep. 229
Chapter 10 Dietary Factors in the Regulation of Selenoprotein Biosynthesisp. 251
Chapter 11 Regulation of Signaling Pathways by Selenium in Cancerp. 273
Chapter 12 Modulation of Gene Expression by Dietary Carotenoids and Retinoids: Role in Cancer Preventionp. 315
Chapter 13 Targeting the Epigenome with Dietary Agentsp. 337
Chapter 14 Effects of Astaxanthin on Microarray Profiling of Gene Expression Patterns of Glomerular Cells in Diabetic Micep. 371
Chapter 15 Insulin Resistance and Inflammatory Signaling Pathways Modulated by High-Fat Dietp. 385
Chapter 16 Molecular Effect of Complex Food Matrices on Endothelial Functions-A Complex Issue to Study: The Case of Winep. 417
Chapter 17 Role of Oxidative Stress in [beta]-Thalassemia and the Antioxidative Effect of Fermented Papaya Preparationp. 431
Chapter 18 Ginkgo Biloba Leaf Extract (EGb 761) Modulates Cell Signaling Associated with Amyloid Beta Oligomers in Alzheimer's Diseasep. 445
Indexp. 465
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