Drugs of abuse : body fluid testing

A comprehensive review of the science of drug testing in all its aspects, placing emphasis on technologies that use body fluids other than urine for determining the presence of drugs of abuse. The authors discuss the various body fluid specimens suitable for testing for illicit drugs-particularly saliva, sweat, and hair-describe the structural and manufacturing aspects of on-site testing devices based on lateral flow immunoassay, and detail the pitfalls of using these specimens. They also discuss in detail the problem of sample adulteration and its detection. Since oral fluid has the best potential of succeeding urine as the next matrix of choice for drug detection, four popular saliva testing devices are examined: Intercept®, the Drager Drug Test®, Oratect®, and Drugwipe. Political, social, and legal issues are also considered in articles on privacy, the use of drug testing in courts, and the problem of sample adulteration.

Lawrence A. ReynoldsLeo J. KadehjianJane S-C. Tsai and Grace L. LinMichael A. MansfieldPaul Christopher and Nikki Robinson and Michael K. ShawDavid CarlbergR. Sam Niedbala and Keith W. KardosStefan Steinmeyer and Rainer Polzius and Andreas MannsRaphael C. WongFranz Aberl and Robert VanDineMichael I. Schaffer and Virginia A. HillMurray LappeAmitava DasguptaRaphael C. Wong and Harley Y. TseJohn N. MarrAlex Yil Fai WongAlain VerstraeteRaphael C. Wong

Preface	p. v
Contributors	p. ix
Chapter 1 Historical Aspects of Drugs-of-Abuse Testing in the United States	p. 1
Chapter 2 Specimens for Drugs-of-Abuse Testing	p. 11
Chapter 3 Drug-Testing Technologies and Applications	p. 29
Chapter 4 The Use of Nitrocellulose Membranes in Lateral-Flow Assays	p. 71
Chapter 5 Antibody-Label Conjugates in Lateral-Flow Assays	p. 87
Chapter 6 Lateral-Flow Assays: Assembly and Automation	p. 99
Chapter 7 Oral-Fluid Drug Testing Using the Intercept" Device	p. 115
Chapter 8 Drager DrugTest": Test for Illegal Drugs in Oral-Fluid Samples	p. 133
Chapter 9 On-Site Oral-Fluid Drug Testing by Oratect"	p. 145
Chapter 10 Saliva and Sweat Testing With Drugwipe(r): A Review	p. 161
Chapter 11 Hair Analysis in Drugs-of-Abuse Testing	p. 177
Chapter 12 Instrumented Urine Point-of-Collection Testing Using the eScreen" System	p. 201
Chapter 13 Adulteration of Drugs-of-Abuse Specimens	p. 215
Chapter 14 Adulteration Detection by Intect" 7	p. 233
Chapter 15 Drug Testing and the Criminal Justice System: A Marriage Made in Court	p. 247
Chapter 16 Drug-of-Abuse Testing: The European Perspective	p. 259
Chapter 17 The Results of the Roadside Drug Testing Assessment Project	p. 271
Chapter 18 Trends in Drug Testing: Concluding Remarks	p. 293
Index	p. 297

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