Available:*
Library | Item Barcode | Call Number | Material Type | Item Category 1 | Status |
|---|---|---|---|---|---|
Searching... | 30000010226381 | QD431 A445 2009 v.3 | Open Access Book | Book | Searching... |
Searching... | 30000010280650 | QD431 A445 2009 v.3 | Open Access Book | Book | Searching... |
On Order
Summary
Summary
This is the first of five books in the Amino Acids, Peptides and Proteins in Organic Synthesis series
Closing a gap in the literature, this is the only series to cover this important topic in organic and biochemistry. Drawing upon the combined expertise of the international "who's who" in amino acid research, these volumes represent a real benchmark for amino acid chemistry, providing a comprehensive discussion of the occurrence, uses and applications of amino acids and, by extension, their polymeric forms, peptides and proteins.
The practical value of each volume is heightened by the inclusion of experimental procedures.
The 5 volumes cover the following topics:
Volume 1: Origins and Synthesis of Amino Acids
Volume 2: Modified Amino Acids, Organocatalysis and Enzymes
Volume 3: Building Blocks, Catalysis and Coupling Chemistry
Volume 4: Protection Reactions, Medicinal Chemistry, Combinatorial Synthesis
Volume 5: Analysis and Function of Amino Acids and Peptides
This first volume is clearly divided into two parts. The first section deals with the origins of extraterrestrial and "terrestrial" amino acids and their evolution. The second part looks at their production and synthesis, including recent developments in the synthesis of ß-Amino acids.
Originally planned as a six volume series, Amino Acids, Peptides and Proteins in Organic Chemistry now completes with five volumes but remains comprehensive in both scope and coverage.
Further information about the 5 Volume Set and purchasing details can be viewed here, eu.wiley.com/WileyCDA/WileyTitle/productCd-3527335463
Author Notes
Andrew Hughes is a reader and Head of the Department of Chemistry, La Trobe University, Melbourne, Australia. He obtained his degrees from the University of Western Australia before taking up post-doctoral appointments at the University of Cambridge starting 1989. After three years working with Professor Andrew Holmes, he joined Professor Steven Ley's group in 1993. While at Cambridge he was appointed the Shell Research Fellow at Robinson College. His interests lie in the general field of asymmetric synthesis and methodology, with a recent focus on amino acid chemistry.
Reviews 1
Choice Review
This is the first of a planned six-volume set reviewing the chemistry of peptides and amino acids. It covers amino acid chemistry, including the origins of amino acids in extraterrestrial and prebiotic Earth, the evolution of biological synthesis of amino acids, and chemical synthesis of both the common and "unusual" amino acids. The work also discusses biosynthetic, in vitro enzymatic, and organic methods of synthesis. Some chapters focusing on organic synthesis contain examples of procedures with reasonable detail. Others simply refer readers to the original source. There are sections dealing with resolution of optical isomers, isotopic labeling, and building analogs of metabolically significant amino acids. Additionally, there are chapters addressing beta, gamma, and other amino acids and their synthesis. Chemists from universities and research institutions worldwide write the chapters, but the style is fairly consistent and the text is readable, if somewhat dry. The illustrations, flow diagrams, and charts are clear and easy to follow; each chapter includes a long list of source documentation referring to the original literature. Future volumes will cover modification, peptides, and analytical techniques. This series would be a valuable addition to the collection of any laboratory where amino acid or peptide chemistry is an emphasis. Summing Up: Recommended. Academic audiences, upper-division undergraduates through researchers/faculty. B. Williams College of St. Catherine
Table of Contents
| Amino Acid Origins |
| Primitive Amino Acid Chemistry Extraterrestrial Amino Acids Terrestrial Amino Acids and Their Evolution |
| The Common alpha-Amino Acids; Proteinogenic Amino Acid Biosynthesis Uncommon alpha-Amino Acid; |
| Non-Proteinogenic Amino Acid Biosynthesis beta-Amino Acid Biosynthesis |
| Synthesis Of Amino Acids |
| Common or Proteinogenic alpha-Amino Acids Fermentation Production of alpha-Amino Acids Radical Synthetic |
| Methods for alpha-Amino Acids Uncommon or Non-Proteinogenic alpha-Amino Acids Synthesis of Non-Coding |
| Amino Acids Synthesis of N-Alkyl Amino Acids Synthesis of beta-Amino Acids Synthesis of Alicyclic beta-Amino Acids |
| Synthesis of alpha,beta-Diamino Acids Synthesis of Halogenated Amino Acids Synthesis of Isotopically Labelled Amino |
| Acids Synthesis of Unnatural/Non-proteinogenic alpha-Amino Acids Synthesis of gamma- and delta-Amino Acids Synthesis of GABA and Amino Acid-Based |
| GABA analogues Synthesis and Chemistry of alpha,beta-Dehydroamino Acids Synthesis and Chemistry of Hydrazino Acids Synthesis and Chemistry of Hydroxamic |
| Acids (N-Hydroxy Amino Acids) Chemistry of Aminoboronic Acids Chemistry of alpha-Aminophosphonic Acids and Phosphonopeptides |
| Chemistry of alpha-Silyl Amino Acids Use of Enzymes in Synthesis of Amino Acids |
