DNA repair and cancer : from bench to clinic

DNA repair is a rapidly advancing field in biology and these systems represent a major defense mechanism against environmental and intracellular damaging agents such as sunlight, ionizing radiation, and reactive oxygen species. With contributions from eminent researchers, this book explores the basics and current trends in this critical field. Topics include carcinogenesis as a predictive and/or prognostic biomarker for cancer therapy, nucleotide excision repair, and tumor genetics and personalized medicine. The contributions provide essential information to scientists, pharmaceutical investigators, and clinicians interested in cancer therapy.

Deborah L. Croteau and Vilhelm A. BohrPaul Hasty and Yousin Suh and Jan VijgRobert A. BeckmanLynn HarrisonTracey D. BradshawMarkus Christmann and Bernd KainaTimothy J. KinsellaMelissa L. Fishel and Carlo Vascotto and Mark R. KelleyLi-E Wang and Qingyi WeiTaraswi Banerjee and Sanjay Kumar Bharti and Robert M. Brosh, Jr.Kinrin Yamanaka and R. Stephen LloydAditi Gurkar and Kiki Chu and Sam W. LeeMarie Fernet and Sara Chiker and Janet HallLaura J. Eccles and Ciara A. O'Driscoll and Alison C. Carley and Egle Balciunaite and Simon N. PowellNicola J. CurtinMary Ellen Urick and Daphne W. BellNorman Chan and Shaqil Kassam and Robert G. BristowMiranda Payne and Mark Middleton

Biography	p. v
Foreword	p. vii
Introduction	p. xi
1 Overview of DNA Repair Pathways	p. 1
2 Longevity Assurance by Genome Maintenance	p. 25
3 Genetic Instability of Cancer: Biological Predictions and Clinical Implications	p. 63
4 Radiation Induced DNA Damage, Repair and Therapeutics	p. 92
5 Chemotherapeutic Alkylating Agents in Cancer Treatment	p. 137
6 O 6 -Methylguanine-DNA Methyltransferase (MGMT) in Cancer Protection and Therapy	p. 174
7 DNA Mismatch Repair: Its Role in Human Carcinogenesis and as a Predictive and/or Prognostic Biomarker for Cancer Therapy	p. 195
8 DNA Base Excision Repair Therapeutics: Summary of Targets with a focus on APE1	p. 233
9 Nucleotide Excision Repair: DNA Repair Capacity Variability and Cancer Susceptibility	p. 288
10 Fanconi Anemia, Interstrand Cross-Link Repair, and Cancer	p. 310
11 Functions of Translesion DNA Polymerases: Implications for Cancer Risk and Opportunities as Therapeutic Targets	p. 325
12 p53 in DNA Damage, Repair and Cancer Therapeutics	p. 372
13 ATM/ATR Cell Cycle Checkpoints: Mechanisms and Manipulation in Cancer Therapy	p. 426
14 The BRCA1-BRCA2 Pathway of Homologous Recombination and the Opportunity for Synthetic Lethal Approaches to Cancer Therapy	p. 470
15 PARP and PARP Inhibitor Therapeutics	p. 513
16 Tumor Genetics and Personalized Medicine	p. 564
17 The Tumor Microenvironment and DNA Repair: Implications for Cancer Progression and Treatment	p. 629
18 Early Phase Clinical Trials Using DNA Repair Inhibitors: Lessons Learnt	p. 664
Index	p. 681
Color Plate Section	p. 687

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