Cover image for Principles of tissue engineering
Title:
Principles of tissue engineering
Edition:
2nd ed.
Publication Information:
Washington, DC : Academic Press, 2000
ISBN:
9780124366305

Available:*

Library
Item Barcode
Call Number
Material Type
Item Category 1
Status
Searching...
30000010019619 TP248.27.A53 P74 2000 Open Access Book Book
Searching...

On Order

Summary

Summary

The opportunity that tissue engineering provides for medicine is extraordinary. In the United States alone, over half-a-trillion dollars are spent each year to care for patients who suffer from tissue loss or dysfunction. Although numerous books and reviews have been written on tissue engineering, none has been as comprehensive in its defining of the field. Principles of Tissue Engineering combines in one volume the prerequisites for a general understanding of tissue growth and development, the tools and theoretical information needed to design tissues and organs, as well as a presentation of applications of tissue engineering to diseases affecting specific organ systems. The first edition of the book, published in 1997, is the definite reference in the field. Since that time, however, the discipline has grown tremendously, and few experts would have been able to predict the explosion in our knowledge of gene expression, cell growth and differentiation, the variety of stem cells, new polymers and materials that are now available, or even the successful introduction of the first tissue-engineered products into the marketplace. There was a need for a new edition, and this need has been met with a product that defines and captures the sense of excitement, understanding and anticipation that has followed from the evolution of this fascinating and important field.


Author Notes

Robert Lanza, M.D. is currently Chief Scientific Officer at Advanced Cell Technology, and Adjunct Professor of Surgical Sciences at Wake Forest University School of Medicine. He has several hundred scientific publications and patents, and over 30 books, including Principles of Tissue Engineering (1st through 4th Editions), Methods of Tissue Engineering, Principles of Cloning (1st and 2nd Editions), Essentials of Stem Cell Biology (1st and 2nd Editions), XENO, Yearbook of Cell & Tissue Transplantation, One World: The Health & Survival of the Human Species in the 21st Century (as editor, with forewords by C. Everett Koop and former President Jimmy Carter), and Medical Science & the Advancement of World Health. Dr. Lanza received his B.A. and M.D. degrees from the University of Pennsylvania, where he was both a University Scholar and Benjamin Franklin Scholar. He is a former Fulbright Scholar, and studied as a student in the laboratory of Richard Hynes (MIT), Jonas Salk (The Salk Institute), and Nobel laureates Gerald Edelman (Rockefeller University) and Rodney Porter (Oxford University). He also worked closely (and coauthored a series of papers) with the late Harvard psychologist B.F. Skinner and heart transplant pioneer Christiaan Barnard. Dr. Lanza's current area of research focuses on the use of stem cells in regenerative medicine.

Robert Langer received honorary doctorates from the ETH (Switzerland) in 1996 and the Technion (Israel) in 1997. Dr. Langer is the Kenneth J. Germeshausen Professor of Chemical and Biomedical Engineering at MIT. He received a Bachelor's Degree from Cornell University in 1970 and a Sc.D. from MIT in 1974, both in chemical engineering. Dr. Langer has written 590 articles, 400 abstracts, 350 patents, and has edited 12 books.Dr. Langer has received over 70 major awards, including the Gairdner Foundation International Award, the Lemelson-MIT prize, the American Chemical Society (ACS) Polymer Chemistry and Applied Polymer Science Awards, Creative Polymer Chemistry Award (ACS, Polymer Division), the Pearlman Memorial Lectureship Award (ACD, Biochemical Technology Division), and the A.I.Ch.E's Walker, Professional Progress, Bioengineering, and Stine Materials Science and Engineering Awards. In 1989, Dr. Langer was elected to the Institute of Medicine and the National Academy of Sciences, and in 1992 he was elected to both the National Academy of Engineering and to the National Academy of Sciences. He is the only active member of all 3 United States National Academies.

Dr. Joseph P. Vacanti received his M.D. degree from the university of Nebraska in 1974. He received his training in general surgery at the Massachusetts General Hospital from 1974 through 1981 and in pediatric surgery at The Children's Hospital, Boston from 1981 through 1983. He then received clinical training in transplantation from the University of Pittsburgh. He spent two years in the laboratories of Dr. M. Judah Folkman working in the filed on angiogenesis from 1977 through 1979. Upon completion of his training, Dr. Vacanti joined the staff in surgery at children's Hospital in Boston and began clinical programs in pediatric liver transplantation and extracorporeal membrane oxygenation. In the laboratory, he continued studies in and began work in the filed of tissue engineering in 1985. Dr. Vacanti is now John Homans Professor of Surgery at Harvard Medical School, Visiting surgeon at Massachusetts General Hospital, director of the Wellman 6 Surgical laboratories, director of the Laboratory of Tissue Engineering and Organ Fabrication and Director of Pediatric Transplantation at Massachusetts General Hospital, Boston. He has authored more than 120 original reports, 30 book chapters, and 197 abstracts. He has more than 25 patents or patents pending in the United States, Europe, and Japan.


Table of Contents

Contributors
ForewordC.A. Vacanti
Preface to the Second Edition
Preface to the First Edition
Tissue Engineering in PerspectiveE. Bell
Introduction to Tissue Engineering
The History and Scope of Tissue EngineeringJ.P. Vavanti and C.A. Vacanti
The Challenge of Imitating NatureR.M. Nerem
Part I The Basis of Growth and Differentiation
Organization of Cells into Higher Ordered StructuresC.A. Erickson
Dynamics of Cell-ECM InteractionsM.Martins-Green
Matrix Molecules and Their LigandsB.R. Olsen
Inductive PhenomenaM. Hebrok and D. A. Melton
Morphogenesis and Tissue EngineeringA.H. Reddi
Cell Determination and DifferentiationL.W. Browder
Part II In Vitro Control of Tissue Development
Mechanical and Chemical Determinants of Tissue DevelopmentD.E. Inger
Animal Cell CultureG.H. Sato and D.W. Barnes
Regulation of Cell Behavior by Matricellular ProteinsA.D. Bradshaw and E.H. Sage
Growth FactorsT.F. Deuel and N. Zhang
Tissue Engineering BioreactorsL.E. Freed and G. Vunjak-Novakovic
Tissue Assembly in MicrogravityB.R. Unsworth and P.I. Lelkes
Part III In Vivo Synthesis of Tissues and Organs
In Vivo Synthesis of Tissues and OrgansL.V. Yannas
Part IV Models for Tissue Engineering
Organotypic and Histiotypic Models of Engineered TissuesE. Bell
Quantitative Aspects of Tissue Engineering: Basic Issues in Kinetics, Transport, and MechanicsA.J. Grodzinsky and R.D. Kamm and Douglas A. Lauffenburger
Part V Biomaterials in Tissue Engineering
Patterning of Cells and Their EnvironmentS. Takayama and R.C. Chapman and R.S. Kane and G.M. Whitesides
Cell Interactions with PolymersW.M. Saltzman
Matrix EffectsJ.A. Hubbell
Polymer Scaffold ProcessingR.C. Thomson and A.K. Shung and M.J. Yaszemski and A.G. Mikos
Biodegradable PolymersJ.M. Pachence and J. Kohn
Part VI Transplantation of Engineered Cells and Tissues
Approaches to Transplanting Engineered Cells and TissuesJ. Hardin-Young and J. Teumer and R.N. Ross and N.L. Parenteau
CryopreservationJ.O.M. Karlsson and M. Toner
ImmunomodulationD. Faustman
ImmunoisolationB.A. Zielinski and M.J. Lysaght
Engineering Challenges in Immunoisolation Device DevelopmentE.S. Avgoustiniatos and H. Wu and C.K. Colton
Part VII Fetal Tissue Engineering
Fetal Tissue EngineeringD.O. Fauza
Pluripotent Stem CellsM.J. Shamblott and B.E. Edwards and J.D. Gearhart
Part VIII Gene Therapy
Gene-Based TherapeuticsL.G. Fradkin and J.D. Ropp and J.F. Warner
Part IX Breast
Breast ReconstructionK.Y. Lee and C.R. Halberstadt and W.D. Holder and D.J. Mooney
Part X Cardiovascular System
Blood VesselsL. Xue and H.P. Greisler
Small-Diameter Vascular GraftsS.J. Sullivan and K.G.M. Brockbank
Cardiac ProsthesesJ.W. Love
Part XI Cornea
CorneaV. Trinkaus-Randall
Part XII Endocrinology and Metabolism
Bioartificial PancreasT.G. Wang and R.P. Lanza
ParathyroidC. Hasse and A Zielke and T. Bohrer and U. Zimmerman and M. Rothmund
Part XIII Gastrointestinal System
Alimentary TractG.M. Organ and J.P. Vacanti
LiverH.O. Jauregui
Hepat Assist Liver Support SystemC. Mullon and B.A. Solomon
Lineage Biology and LiverA.S.L. Xu and T.L. Luntz and J.M. Macdonald and H. Kubota and E. Hsu and R.E. London and L.M. Reid
Part XIV Hematopoietic System
Red Blood Cell SubstitutesT.M.S. Chang
Lymphoid CellsU. Chen
Hematopoietic Stem CellsA. Kessinger and G. Sharp
Part XV Kidney and Genitourinary System
Renal Replacement DevicesH.D. Humes
Genitourinary SystemB.-S. Kim and D.J. Mooney and A. Atala
Part XVI Musculoskeletal System
Structural Tissue EngineeringC.A. Vacanti and L.J. Bonassar and J.P. Vacanti
Bone Regeneration through Cellular EngineeringS.P. Bruder and A.I. Caplan
Articular Cartilage InjuryJ.M. McPherson and R. Tubo
Tendons and LigamentsF. Goulet and D. Rancourt and R. Cloutier and L. Germain and A.R. Poole and F.A. Auger
Mechanosensory Mechanisms in BoneS.C. Cowin and M.L. Moss
Myoblast TherapyJ.C. Cousins and J.E. Morgan and T.A. Partridge
Part XVII Nervous System
Protection and Repair of HearingR.A. Altschuler and Y. Raphael and J. Schacht and D.J. Anderson and J.M. Miller
Vision Enhancement SystemsG. Dagnelie and M.S. Humayun and R.W. Massof
Brain ImplantsLars U. Wahlberg
Nerve RegenerationE.G. Fine and R.F. Valentini and P. Aebischer
Transplantation Strategies for Treatment of Spinal Cord Dysfunction and InjuryJ. Sagen and M.B. Bunge and N. Kleitman
Neural Stem CellsM.P. Vacanti
Part XVIII Periodontal and Dental Applications
Periodontal ApplicationsN.A. Miller and M.C. Béné and J.P. and P. Ambrosini and G.C. Faure
Regeneration of DentinR.B. Rutherford
Part XIX Skin
Wound Repair: Basic Biology to Tissue EngineeringR.A.F. Clark and A.J. Singer
SkinN.L. Parenteau and J. Hardin-Young and R.N. Ross
Dermal EquivalentsG.K. Naughton
Part XX Womb
Artificial WombC.S. Muratore and J.M. Wilson
Part XXI Regulatory Issues
Regulatory ConsiderationsK.B. Hellman and R.R. Solomon and C. Gaffey and C.N. Durfor and J.G. Bishop
Epilogue
Index