Guanine quartets : structure and application

Library	Item Barcode	Call Number	Material Type	Item Category 1	Status
Searching... Perpustakaan Raja Zarith Sofiah	35000000000783	QP552.G16 G83 2013	Open Access Book	Book	Searching... Unknown
Searching... PSZ JB	30000010323151	QP552.G16 G83 2013	Open Access Book	Book	Searching... Unknown

Guanosine and its derivatives have a high potential for self-recognition and self-assembly, as well as the recognition ability for other biologically important molecules. This book explores in detail these properties with the goal of increasing knowledge of the basic principles of guanosine-assembly, synthesis of new optimised materials and exploration of their electronic and optical properties. Following the work of COST Action MP0802, the aim is to design novel reproducible and well ordered supramolecular structures to serve as molecular-scale architectures for new hybrid molecular electronics. Coverage includes synthesis, characterisation and optimisation, theoretical modelling and prediction, biochemical and biorecognition properties and applications in nanotechnology especially in molecular electronics. Appealing to researchers working in the field ranging from chemists, biologists and material scientists, this title will be a welcome addition to the inter-disciplinary literature providing direction for future research and ideas for industrial applications.

Lea SpindlerGang WuJ.M RiveraStefano Masiero and Silvia Pieraccini and Gian Piero SpadaArtur Ciesielski and Mathieu Surin and Gian Piero Spada and Paolo SamorT.C. Marsh and Z.M. Henseler and M.A. KlimstraC GiancolaSoma Dhakal and Hanbin Mao and Arivazhagan Rajendran and Masayuki Endo and Hiroshi SugiyamaGian Piero SpadaA. Aviñó and R. EritjaA.-M. Chiorcea-Paquim and P. Santos and V. C. Diculescu and R. Eritja and A.M. Oliveira-BrettJames VesenkaLea SpindlerE. Jr. Baldassarri and M. G. Ortore and A. Gonnelli and M. Marcinekova and S. Mazzoni and M. L. Travaglini and P. MarianiL. Coga and M. Devetak and S. Masiero and G.P. Spada and I. Drevenšek-OlenikShozeb HaiderMateus Webba da Silva and Andreas Ioannis KarsisiotisGábor Paragi and János Szolomájer and Zoltán Kupihár and Gyula Batta and Zoltán Kele and Petra Pádár and Botond Penke|cHester Zijlstra and Célia Fonseca Guerra and F. Matthias Bickelhaup and Lajos KovácsB. Islam and V. D'Atri and M. Sgobba and J. Husby and S. HaiderMateus Webba da SilvaNancy MaizelsMichael FryG. N. ParkinsonE. Largy and M.-P. Teulade-FichouKogularamanan Suntharalingam and Ramon VilarWolfgang FritzscheDipankar SenJoanna Kosman and Bernard JuskowiakDomenica Musumeci and Daniela MontesarchioChristian Leiterer and Andreas Kopielski and Irit Lubitz and Alexander Kotlyar and Antti-Pekka Eskelinen and Päivi Törmä and Wolfgang FritzscheT. Parviainen and G. Eidelshten and A. Kotlyar and J.J. ToppariDvir Rotem and Gennady Eidelshtein and Alexander Kotlyar and Danny Porath

Chapter 1 Introduction: From G-Quartet to G-Quadruplex and its Nanoarchitectures	p. 1
Guanylic acid Self-Assembly: 100 years on	p. 3
Functional Assemblies made from Supramolecular G-Quadruplexes	p. 15
Self-Assembly of Lipophilic Guanosines: Switching between different Assemblies	p. 28
Nanopatterning the Surface with ordered Supramolecular Architectures: Controlling the Self-Assembly of Guanine-based Hydrogen-Bonded Motifs	p. 40
Morphological Heterogeneity of Supramolecular G-DNA Polymers derived from Guanine Rich Oligonucleotides	p. 48
Thermondynamics of G-Quadruplexes	p. 63
G-Quadruplex Nanostructures Probed at the Single Molecular Level by Force-Based Methods	p. 73
Chapter 2 Introduction: Synthesis and Characterization	p. 87
Synthesis and Properties of Oligonucleotides Forming G-Quadruplexes	p. 89
Electrochemical Characterization of Guanine Quadruplexes	p. 100
AFM of Guanine Rich Oligonucleotide Surface Structures	p. 110
Solution Dynamics and Structure of G-Quadruplexes Studied by Dynamic Light Scattering	p. 121
GMP-Quadruplex Structures in Dilute Solutions and in Condensed Phases: An X-Ray Scattering Analysis	p. 135
Temperature-Gradient Gel Electrophoresis: Unfolding of G-QuadruplexesViktor Víglaský and Katarína Tlucková and Petra Tóthová
Specific Behaviour of Guanosine in Liponucleoside Thin Films	p. 154
Chapter 3 Theoretical Modelling, Analysis and Prediction	p. 165
Fundamentals and Applications of the Geometric Formalism of Quadruplex Folding	p. 167
Guanine, Xanthine and Uric Acid Assemblies: Comparative Theoretical and Experimental Studies	p. 179
Computational Methods for Studying G-Quadruplex Nuceic Acids	p. 194
Chapter 4 Introduction: Recognition of Quadruplexes	p. 213
Biological Functions of G-Quadruplexes	p. 215
Regulation of Gene Transcription by DNA G-Quadruplexes	p. 223
The Reality of Quadruplex Nucleic Acids as a Therapeutic Target	p. 237
Screening for Quadruplex Binding Ligands: A Game of Chance?	p. 248
Recognition of G-Quadruplexes by Metal Complexes	p. 263
Chapter 5 Introduction: Applications in Bioanalytics, Therapy and Molecular Electronics	p. 275
Catalytic G-Quadruplexes	p. 277
Catalytic G-Quadruplexes for the Detection of Telomerase Activity	p. 285
G-Quadruplex forming Oligonucleotides with Tailor-made Modifications as effective aptamers for Potential Therapeutic Applications	p. 292
Dep-Based Integration of G-Quadruplex Structures	p. 306
Conductive Behaviour of G4-DNA-Silver Nanoparticle Structures	p. 314
Novel Materials for Molecular Electronics - Synthese and Characterization of Long G4-DNA	p. 324
Subject Index	p. 337

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