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Library | Item Barcode | Call Number | Material Type | Item Category 1 | Status |
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Searching... | 30000010222717 | QH457 A53 2010 f | Open Access Book | Book | Searching... |
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Summary
Summary
Principles of Behavioral Genetics provides an introduction to the fascinating science that aims to understand how our genes determine what makes us tick. It presents a comprehensive overview of the relationship between genes, brain, and behavior.
Introductory chapters give clear explanations of basic processes of the nervous system and fundamental principles of genetics of complex traits without excessive statistical jargon. Individual chapters describe the genetics of social interactions, olfaction and taste, memory and learning, circadian behavior, locomotion, sleep, and addiction, as well as the evolution of behavior.
Whereas the focus is on genetics, neurobiological and ecological aspects are also included to provide intellectual breadth. The book uses examples that span the gamut from classical model organisms to non-model systems and human biology, and include both laboratory and field studies. Samples of historical information accentuate the text to provide the reader with an appreciation of the history of the field.
This book will be a valuable resource for future generations of scientists who focus on the field of behavioral genetics.
Table of Contents
Preface |
Chapter 1 Introduction and Historical Perspective |
Overview |
The Rise of the Modern Field of Behavioral Genetics |
The Modern Evolutionary Synthesis |
The Rise of Molecular Genetics |
A Brief History of Neuroscience |
The Emergence of Behavioral Genetics |
Summary |
Study Questions |
Recommended Reading |
Chapter 2 Mechanisms of Neural Communication |
Overview |
Transmission of Information in the Nervous System |
The Resting Membrane Potential |
The Mechanism of the Action Potential |
Ion Channels, G-protein-coupled Receptors, and Signal Transduction |
Summary |
Study Questions |
Recommended Reading |
Chapter 3 Functional Organization of the Nervous System |
Overview |
The Organization of the Mammalian Nervous System |
Communication between the Brain and the Periphery |
Organization of the Nervous System in Insects |
Neurotransmitters |
Summary |
Study Questions |
Recommended Reading |
Chapter 4 Measuring Behavior: Sources of Genetic and Environmental Variation |
Overview |
Behavioral Assays |
Controlling Experimental Variation |
Sources of Variation in Behavior |
Effects of Mutations on Behavioral Phenotypes |
Environmental Variation |
Gene - Environment Correlation and Interaction |
Summary |
Study Questions |
Recommended Reading |
Chapter 5 Mapping Genotype to Phenotype in Populations |
Overview |
Genes in Populations: Random Mating |
Genes in Populations: Inbreeding |
Quantitative Genetic Model |
Summary |
Study Questions |
Recommended Reading |
Chapter 6 Partitioning Phenotypic Variance and Heritability |
Overview |
Components of Variance in Random Mating Populations |
Genotype-Environment Correlation and Interaction |
Partitioning Phenotypic Variance |
Heritability : The Concept |
Controlling and Estimating Environmental Components of Variation |
Summary |
Study Questions |
Recommended Reading |
Chapter 7 Estimating Heritability |
Overview |
Phenotypic Resemblance between Relatives |
Genetic Causes of Covariance between Relatives |
Environmental Causes of the Relationship between Relatives |
Heritability Estimates in Humans |
Heritability in Other Populations |
Estimates of Heritability for Behavioral Traits |
Summary |
Study Questions |
Recommended Reading |
Chapter 8 Quantitative Trait Locus Mapping |
Overview |
Linkage Mapping |
Interval Mapping |
Statistical Analysis |
Association Mapping |
Quantitative Trait Locus End Game |
Summary |
Study Questions |
Recommended Reading |
Chapter 9 Mutagenesis and Transgenesis |
Overview |
The Occurrence or Induction of Mutations |
Homologous Recombination |
Transposon -mediated Mutagenesis |
The GAL4-UAS Binary Expression System in Drosophila |
RNA Interference |
Summary |
Study Questions |
Recommended Reading |
Chapter 10 Genomics Approaches in Behavioral Genetics |
Overview |
Detecting Large-scale Gene Expression |
Parallel Sequencing and Transcriptional Analysis |
Plasticity of Transcriptional Profiles |
Analysis of Whole-genome Expression Microarray |
Defining Statistical Signifi cance Threshold |
Identifying Genetic Networks |
Summary |
Study Questions |
Recommended Reading |
Chapter 11 Neurogenetics of Activity and Sleep |
Overview |
Locomotion |
Genetics of Human Locomotion Disorders |
Circadian Rhythms |
Sleep |
Summary |
Study Questions |
Recommended Reading |
Chapter 12 Genetics of Social Interactions |
Overview |
Social Environment and the Genes-Brain-Behavior Paradigm |
Social Cooperation and Fitness |
Courtship and Mate Selection |
Affiliative Behavior |
Aggression and the Establishment of Social Hierarchies |
Division of Labor: The Genetics of Social Structure |
Aggregation Behavior |
Summary |
Study Questions |
Recommended Reading |
Chapter 13 Genetics of Olfaction and Taste |
Overview |
The Study of Olfaction |
The Discovery of Odorant Receptors |
Transgenic Approaches to Determine Odorant Receptor Response Profiles |
Transgenic Approaches to Map Projection Patterns of Olfactory Sensory Neurons |
The Use of Transgenic Reporter Genes to Visualize Odor Coding |
Taste and Gustatory Receptors |
Summary |
Study Questions |
Recommended Reading |
Chapter 14 Learning and Memory |
Overview |
Forming Memories |
Memory Formation: Cellular Mechanisms |
Harnessing the Power of Genetics: Learning in Drosophila |
Identifying Genetic Networks for Learning and Memory |
Learning Disabilities |
Neurodegeneration and Memory Impairment: Alzheimer's Disease |
Summary |
Study Questions |
Recommended Reading |
Chapter 15 Genetics of Addiction |
Overview |
Hallmarks of Addiction |
Alcoholism |
Linkage and Association Studies |
Alcohol Sensitivity in Model Organisms |
Alcohol-related Phenotypes in Rodent Models |
Smoking |
Drug Addiction |
Summary |
Study Questions |
Recommended Reading |
Chapter 16 Evolution of Behavior |
Overview |
Population Genetics and Evolution |
Models of Evolution |
Selection Models |
Assessing Deviations from Neutrality |
Behavior as a Vehicle for Evolution |
Insect-Host Plant Interactions: An Example of Evolutionary Adaptation |
Co-evolution of Sexual Communication Systems |
Study Questions |
Recommended Reading |
Chapter 16 Evolution of Behavior |
Overview |
Population Genetics and Evolution |
Models of Evolution |
Selection Models |
Assessing Deviations from Neutrality |
Behavior as a Vehicle for Evolution |
Insect-Host Plant Interactions: An Example of Evolutionary Adaptation |
Co-evolution of Sexual Communication Systems |
The Evolutionary Genetics of Burrowing and Nest Building |
The Astounding Diversity of Cichlids and Sticklebacks |
Understanding the Evolution of Behavior: How Much Do We Really Know? |
Summary |
Study Questions |
Recommended Reading |
Glossary |
Index |