Systems biology and synthetic biology

Library	Item Barcode	Call Number	Material Type	Item Category 1	Status
Searching... PSZ JB	30000010230913	TP248.2 S97 2009	Open Access Book	Book	Searching... Unknown
Searching... PSZ JB	30000010334482	TP248.2 S97 2009	Open Access Book	Book	Searching... Unknown

The genomic revolution has opened up systematic investigations and engineering designs for various life forms. Systems biology and synthetic biology are emerging as two complementary approaches, which embody the breakthrough in biology and invite application of engineering principles. Systems Biology and Synthetic Biology emphasizes the similarity between biology and engineering at the system level, which is important for applying systems and engineering theories to biology problems. This book demonstrates to students, researchers, and industry that systems biology relies on synthetic biology technologies to study biological systems, while synthetic biology depends on knowledge obtained from systems biology approaches.

Author Notes

Pengcheng Fu, PhD, is a professor in the Faculty of Chemical Science and Engineering, China University of Petroleum, Beijing. His research interests include: biofuels and bioenergy, metabolic engineering, functional genomics, genome-scale modeling, bioprocess control, metabolomics/metabolite profiling, systems biology, and synthetic biology.
Dr. Sven Panke is an associate professor and leader of the Bioprocess Laboratory at the Department of Mechanical and Process Engineering of the ETH Zurich, Switzerland. His main interests are the design of novel biocatalysts for applications in chemistry and pharmacy by synthetic biology approaches.

Pengcheng FuMichael X. Wang and Huidong ShiXiu-Feng Wan and Dorothea K. ThompsonGordon S. OkimotoMitsuhiro ItayaAndrew R. Joyce and Bernhard Ø. PalssonDelphine Ropers and Hidde de Jong and Johannes GeiselmannJordi Vallverdú and Claes GustafssonGoutham Vemuri and Jens NielsenSang Yup Lee and Jin Sik Kim and Hongseok Yun and Tae Yong Kim and Seung Bum Sohn and Hyun Uk KimMatthias Heinemann and Sven PankeMarcus Graf and Thomas Schoedl and Ralf WagnerPhilipp Holliger and David LoakesWilson W. Wong and James C. LiaoDavid Greber and Martin FusseneggerHiroaki KitanoWenlong Cheng and Liang Ding and Hisakage Funabashi and Nokyoung Park and Soong Ho Um and Jianfeng Xu and Dan LuoGuangyi Wang and Juanita MathewsCliff HookerPengcheng Fu and Cliff Hooker

Foreword	p. ix
Contributors	p. xi
1 Introduction	p. 1
2 Basics of Molecular Biology, Genetic Engineering, and Metabolic Engineering	p. 9
3 High-Throughput Technologies and Functional Genomics	p. 67
4 Genomic Signal Processing of DNA Microarray Data for the Enhanced Prediction of Axillary Lymph Node Status of Breast Cancer Tumors	p. 115
5 Recombinant Genomes: Novel Resources for Systems Biology and Synthetic Biology	p. 155
6 In silico Genome-Scale Metabolic Models: The Constraint-Based Approach and its Applications	p. 193
7 Mathematical Modeling of Genetic Regulatory Networks: Stress Responses in Escherichia coli	p. 235
8 Synthetic Life: Ethobricks for a New Biology	p. 273
9 Yeast as a Prototype for Systems Biology	p. 287
10 Construction and Applications of Genome-Scale in silico Metabolic Models for Strain Improvement	p. 355
11 Synthetic Biology: Putting Engineering into Bioengineering	p. 387
12 Rationales of Gene Design and de novo Gene Construction	p. 411
13 Self-Replication in Chemistry and Biology	p. 439
14 The Synthetic Approach for Regulatory and Metabolic Circuits	p. 467
15 Synthetic Gene Networks	p. 489
16 The Theory of Biological Robustness and its Implication to Cancer	p. 529
17 Nucleic Acid Engineering	p. 549
18 Potential Applications of Synthetic Biology in Marine Microbial Functional Ecology and Biotechnology	p. 577
19 On Fundamental Implications of Systems and Synthetic Biology	p. 593
20 Outstanding Issues in Systems and Synthetic Biology	p. 615
Index	p. 647

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Table of Contents