1. An introduction to chronic myeloid leukemia -- 2. A historical perspective of chronic myeloid leukemia -- 3. Cytogenetics, molecular anatomy, and molecular biology of chronic myeloid leukemia -- 4. Clinical aspects, prognostic and predictive factors -- 5. Primary treatment of chronic myeloid leukemia -- 6. Secondary treatment and stem cell transplantation for chronic myeloid leukemia -- 7. Emerging and investigational treatment for chronic myeloid leukemia -- 8. Defi nitions of response and monitoring response for patients with chronic myeloid leukemia -- 9. Resistance to tyrosine kinase inhibitors and novel insights into genomic instability of chronic myeloid leukemia stem cells -- 10. Concluding thoughts