Title:
Structure and mechanism in protein science : a guide to enzyme catalysis and protein folding
Personal Author:
Publication Information:
New York, NY : W. H. Freeman, 1999
Physical Description:
xxi, 631 p. : ill. ; 25 cm.
ISBN:
9780716732686
Available:*
Library | Item Barcode | Call Number | Material Type | Item Category 1 | Status |
|---|---|---|---|---|---|
Searching... | 30000010170273 | QD431.25.S85 F47 1999 | Open Access Book | Book | Searching... |
On Order
Summary
Summary
Fersht's Structure and Mechanism in Protein Science is a defining exploration of this new era, an expert depiction of the core principles of protein structure, activity, and mechanism as understood and applied today.nbsp; A thorough recasting of Fersht's previous text, the book takes a more general look at mechanisms in protein science, emphasizing the unity of concepts in folding and catalysis and the importance of the relationships between basic chemistry, kinetics, thermodynamics, and structure.
Table of Contents
| 1 The Three-dimensional Structure of Proteins |
| 2 Chemical Catalysis |
| 3 The Basic Equations of Enzyme Kinetics |
| 4 Measurement and Magnitude of Enzymatic Rate Constants |
| 5 The pH Dependence of Enzyme Catalysis |
| 6 Practical Kinetics |
| 7 Detection of Intermediates in Reactions by Kinetics |
| 8 Stereochemistry of Enzymatic Reactions |
| 9 Active-site-directed and Enzyme-activated Irreversible Inhibitors: Affinity Labels and Suicide Inhibitors |
| 10 Conformational Change, Allosteric Regulation, Motors, and Work |
| 11 Forces Between Molecules and Enzyme-Substrate Binding Energies |
| 12 Enzyme-substrate Complementarity and the Use of Binding Energies in Catalysis |
| 13 Specificity and Editing Mechanisms |
| 14 Recombinant DNA Technology |
| 15 Case Studies of Enzyme Structure and Mechanism |
| 16 Protein Engineering |
| 17 Protein Stability |
| 18 Kinetics of Protein Folding |
| 19 Folding Pathways and Energy Landscapes |
