Cover image for Membrane separations in biotechnology
Title:
Membrane separations in biotechnology
Series:
Biotechnology and bioprocessing series ; 26
Edition:
2nd ed. Revised and Expanded
Publication Information:
New York : Marcel Dekker, 2001
ISBN:
9780824702489
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30000010062190 TP248.25.M46 M45 2001 Open Access Book Book
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Summary

Summary

This text details the relationship between membrane technology and bioprocesses, discussing applications. This second edition refines and optimizes key features of the first edition - and features new illustrative case studies. The book examines advantages and disadvantages of using standard and new membrane technologies; analyzes a wide range of applications, including cell culture harvesting and product and process validation techniques; and more.


Author Notes

Jenifer L. Ayala Associate Scientist, CMC and BRD, Berlex Biosciences, Richmond, California
Mahmood R. Azari Director of Project Implementation, Recombinant Business Unit/Manufacturing, Hyland Immuno Division, Baxter Healthcare Corporation, Thousand Oaks, California
Bernard P. Bautista Process Development Scientist, Process Sciences, Biotechnology Unit, Pharmaceutical Division, Bayer Corporation, Berkeley, California
Bruce D. Bowen Department of Chemical and Bio-Resource Engineering, University of British Columbia, Vancouver, British Columbia, Canada
Francisco J. Castillo Scientific Director, Fermentation and Cell Culture Development, Berlex Biosciences, Richmond, California
G. Michael Connell Senior Associate Process Scientist, Process Sciences, Biotechnology Unit, Pharmaceutical Division, Bayer Corporation, Berkeley, California
Alfred C. Dadson Jr. Principal Scientist I, Process Sciences, Biotechnology Unit, Pharmaceutical Division, Bayer Corporation, Berkeley, California
Robert H. Davis Pattern Professor, Department of Chemical Engineering, University of Colorado, Boulder, Colorado
Igor Yu. Galaev Associate Professor, Department of Biotechnology, Center for Chemistry and Chemical Engineering, Lund University, Lund, Sweden
Kent E. Goklen Director, BioProcess Research and Development, Merck Research Laboratories, Rahway, New Jersey
Joseph I. Horwitz Fermentation and Cell Culture Development, Berlex Biosciences, Richmond, California
Ping Yu Huang Senior Process Engineer, Manufacturing Services, Protein Design Labs, Inc., Fremont, California
Brian D. Kelley Associate Director, Purification Process Development, Genetics Institute, Andover, Massachusetts
Marek Labecki Department of Chemical and Biological Engineering, The Biotechnology Laboratory, University of British Columbia, Vancouver, British Columbia, Canada
Bo Mattiasson Professor, Department of Biotechnology, Center for Chemistry and Chemical Engineering, Lund University, Lund, Sweden
W. Courtney McGregor Vice President, Technical Development and Santa Monica Operations, XOMA Corporation, Santa Monica, California
Michael Meagher Assistant Professor, Food Science Department, University of Nebraska, Lincoln, Nebraska
Gautam Mitra Manufacturing Department, SmithKline Beecham Biologicals, Rixensart, Belgium
Harold G. Monbouquette Associate Professor, Chemical Engineering Department, University of California, Los Angeles, California
Thomas J. Monica Scientist, Fermentation and Cell Culture Development. Berlex Biosciences, Richmond, California
Tana J. Montgomery Associate Scientist, Clinical Production, Berlex Biosciences, Richmond, California
Paul K. Ng Principal Research Scientist II, Purification Development, Process Sciences, Biotechnology Unit, Pharmaceutical Division, Bayer Corporation, Berkeley, California
Kristen F. Ogle Senior Research Scientist, Renal Division, Baxter Healthcare Corporation, McGaw Park, Illinois
John Peterson Associate Scientist, Protein Design Labs, Inc., Fremont, California
Jon T. Petrone Principal Engineer, Drug Substance Development, Genetics Institute, Andover, Massachusetts
James M. Piret Professor, Department of Chemical and Biological Engineering and Biotechnology Laboratory, University of British Columbia, Vancouver, British Columbia, Canada
Georg Roth Senior Scientist, Fermentation and Cell Culture Development, Berlex Biosciences, Richmond, California
Gregory Russotti Research Fellow, BioProcess Research and Development, Merck Research Laboratories, Rahway, New Jersey
Vicki L. Schlegel Assistant Professor, Food Science Department, University of Nebraska, Lincoln, Nebraska
Gary M. Schoofs Clinical Production Manager, Clinical Production, Berlex Biosciences, Richmond, California
Peter Schu Director, Vaccines Bulk Manufacturing, Manufacturing Department, SmithKline Beecham Biologicals, Rixensart, Belgium
Clayton E. Smith Berlex Biosciences, Richmond, California
Robert van Reis Distinguished Engineer, Department of Recovery Sciences, Genentech, Inc., South San Francisco, California
William K. Wang Assistant Director, Biopharmaceutical Development, Downstream Process Development, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania
Andrew L. Zydney Professor, Department of Chemical Engineering, University of Delaware, Newark, Delaware


Table of Contents

Marek Labecki and Bruce D. Bowen and James M. PiretGeorg Roth and Clayton E. Smith and Gary M. Schoofs and Tana J. Montgomery and Jenifer L. Ayala and Thomas J. Monica and Francisco J. Castillo and Joseph I. HorwitzGregory Russotti and Kent E. GoklenRobert H. DavisVicki L. Schlegel and Michael MeagherPaul K. Ng and Alfred C. Dadson Jr. and G. Michael Connell and Bernard P. BautistaPeter Schu and Gautam MitraIgor Yu. Galaev and Bo MattiassonWilliam K. Wang and Harold G. Monbouquette and W. Courtney McGregorAndrew L. Zydney and Robert van ReisKristen F. Ogle and Mahmood R. AzariPing Yu Huang and John PetersonBrian D. Kelley and Jon T. Petrone
Series Introductionp. iii
Prefacep. v
Contributorsp. ix
1. Protein Transport in Ultrafiltration Hollow-Fiber Bioreactors for Mammalian Cell Culturep. 1
2. Vortex Flow Filtration for Cell Separation in Bioreactor Operationsp. 63
3. Crossflow Membrane Filtration of Fermentation Brothp. 85
4. Crossflow Microfiltration with Backpulsingp. 161
5. Effects of Different Membrane Modular Systems on the Performance of Crossflow Filtration of Pichia pastoris Suspensionsp. 189
6. Filter Applications in Product Recovery Processesp. 205
7. Ultrafiltration Membranes in the Vaccine Industryp. 225
8. Protein Purification by Affinity Ultrafiltrationp. 243
9. Process Development for the Isolation of a Recombinant Immunofusion Protein Using a Membrane Adsorberp. 263
10. High-Performance Tangential-Flow Filtrationp. 277
11. Virus Removal by Ultrafiltration: A Case Study with Diaspirin Crosslinked Hemoglobin (DCLHb)p. 299
12. Scaleup and Virus Clearance Studies on Viral Filtration in Monoclonal Antibody Manufacturep. 327
13. Virus Removal by Tangential-Flow Filtration for Protein Therapeuticsp. 351
Indexp. 397