Nanotechnology and tissue engineering : the scaffold

Nanofabrication gives us the ability to mimic biological structures with molecular level precision. Offering a natural progression of topics, Nanotechnology and Tissue Engineering: The Scaffoldprovides a state-of-the-art account of groundbreaking research in this rapidly emerging area of biomedical engineering.

Emphasizing the importance of scaffolds, the book details fundamental and advanced aspects of nanofabrication and examines cellular interactions at the nanoscale level. It reviews extracellular matrix structure and function and discusses various nanoscale biological surface modifications that can improve cellular responses. The editors present the most promising nanofabrication techniques, including electrospinning, lithography, and self assembly. Featuring the contributions of pioneering scientists writing about their own research, this cutting-edge volume --

Provides background information discussing the emerging importance of scaffolds in tissue engineering Examines tissue engineering as it relates to orthopedic, cardiovascular, neural, and musculoskeletal applications Details cell responses to a number of nanoscale features Delves into microfabrication techniques in scaffold development Presents research on designer self-assembling peptide scaffolds

This highly comprehensive resource also discusses clinical implications and applications, presenting exciting breakthroughs in neural, vascular, and musculoskeletal tissue engineering with nanostructures. An essential resource, for biomedical engineers working on the frontiers of tissue research, this book brings together current findings and background information on a complete range of engineering processes that have led to the development of a number of highly useful tissues.

Fan Yang and William L. Neeley and Michael J. Moore and Jeffrey M. Karp and Anita Shukla and Robert LangerMandana Veiseh and Eva A. Turley and Mina J. BissellTejas Shyam Karande and C. Mauli AgrawalChristopher J. Bettinger and Jeffrey T. Borenstein and Robert LangerBatur Ercan and Thomas WebsterDuron A. Lee and Cato T. LaurencinSyam Prasad Nukavarapu and Sangamesh G. Kumbar and Jonathan G. Merrell and Cato T. LaurencinEunice Phay Shing Tan and Chwee Teck LimJoel K. Wise and Michael Cho and Eyal Zussman and Constantine M. Megaridis and Alexander L. YarinBenjamin Moody and Gregory S. McCartyAkihiro Horii and Xiumei Wang and Shuguang ZhangVivek Mukhatyar and Julie Yeh and Ravi BellamkondaKristen A. Wieghaus and Edward A. BotchweySusan Liao and Casey K. Chan and Seeram Ramakrishna

Foreword	p. ix
Preface	p. xi
Editors	p. xiii
Contributors	p. xv
Section I Importance of Scaffolds in Tissue Engineering
Chapter 1 Tissue Engineering: The Therapeutic Strategy of the Twenty-First Century	p. 3
Chapter 2 Top-Down Analysis of a Dynamic Environment: Extracellular Matrix Structure and Function	p. 33
Chapter 3 Functions and Requirements of Synthetic Scaffolds in Tissue Engineering	p. 53
Chapter 4 Microfabrication Techniques in Scaffold Development	p. 87
Section II Effect of Nanostructures on Cellular Responses and Tissue Regeneration
Chapter 5 Cell Response to Nanoscale Features and Its Implications in Tissue Regeneration: An Orthopedic Perspective	p. 123
Chapter 6 Surface Modification of Biomaterials at the Nanoscale: Biomimetic Scaffolds for Tissue Engineering Applications	p. 163
Section III Promising Nanofabrication Techniques to Develop Scaffolds for Tissue Engineering
Chapter 7 Electrospun Polymeric Nanofiber Scaffolds for Tissue Regeneration	p. 199
Chapter 8 Structure and Mechanical Properties of Electrospun Nanofibers and Nanocomposites	p. 221
Chapter 9 Electrospinning Techniques to Control Deposition and Structural Alignment of Nanofibrous Scaffolds for Cellular Orientation and Cytoskeletal Reorganization	p. 243
Chapter 10 Nanolithographic Techniques in Tissue Engineering	p. 261
Chapter 11 Designer Self-Assembling Peptide Scaffolds for Tissue Engineering and Regenerative Medicine	p. 283
Section IV Applications of Nanostructured Scaffolds in Biology and Medicine
Chapter 12 Nanotechnologies in Neural Tissue Engineering	p. 295
Chapter 13 Nanotechnologies for Cardiovascular Tissue Engineering	p. 311
Chapter 14 Nanostructures for Musculoskeletal Tissue Engineering	p. 329
Index	p. 353

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