Cover image for Physiological and clinical aspects of short-chain fatty acids
Title:
Physiological and clinical aspects of short-chain fatty acids
Publication Information:
Cambridge : Cambridge University Press, 2004
ISBN:
9780521616133

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30000010042336 QP752.F35 P49 2004 Open Access Book Book
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30000004726380 QP752.F35 P49 2004 Open Access Book Book
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Summary

Summary

This is the first comprehensive volume to look at the importance of short-chain fatty acids in digestion, the function of the large intestine and their role in human health. Short-chain fatty acids are the major product of bacterial fermentation of dietary carbohydrates in the human and animal large intestine. They represent the major end products of digestive processes occurring in the caecum and large intestine. As such, they form an important dietary component and it is increasingly recognised that they may have a significant role in protecting against large bowel cancer and in metabolism. Prepared by an international team of contributors who are at the forefront of this area of research, this volume will be an essential source of reference for gastroenterologists, nutritionists and others active in this area.


Table of Contents

1 Definitions and historyO. M. Wrong
2 Chemistry of short-chain fatty acids (SCFA)M. Fukushima
3 Measurement of acetate by enzymatic methodsM. Elia and G. Jennings
4 Biochemistry and microbiology in the rumenR. J. Wallace
5 SCFA in the hindgutG. Breves and K. Stuck
6 Microbiological aspects of SCFA production in the large bowelG. T. Macfarlane and G. R. Gibson
7 Reductive acetogenesis in animal and human gutM. Durand and A. Bernalier
8 Flow dynamics of digesta and colonic fermentationI. D. Hume
9 Transport of SCFA in the ruminant forestomachG. Gabel
10 Absorption of SCFA from the large intestineW. V. Engelhardt
11 Metabolism of SCFA in the liverC. Remesy and C. Demigne and C. Morand
12 Effects of SCFA from the large intestineC. Cherbut
13 Sensory mechanisms for SCFA in the colonT. Yajima
14 Effects of SCFA on exocrine and endocrine pancreatic secretionK. Katoh
15 Effect of SCFA on salivary flow in ruminantsP. Norgaard
16 Utilization of volatile fatty acids in ruminantsE. R. Orskov
17 SCFA, pancreatic hormones and appetite controlA. de Jong
18 Effects of butyrate on cell proliferation and gene expressionJ. Kruh and N. Defer and L. Tichonicky
19 Effects of SCFA on gut epithelial cell proliferation in vivoT. Sakata
20 SCFA and colon tumorigenesisJ. R. Lupton
21 Butyrate and the human cancer cellG. P. Young and P. R. Gibson
22 The place of SCFAs in coloncyte metabolism in health and ulcerative colitisW. E. W. Roediger
23 Management of diversion colitis, pouchitis and distal ulcerative colitisW. Scheppach and P. Bartram and F. Richter
24 The effects of SCFA on phagocytic cell functionG. F. Brisseau and O. D. Rotstein
25 SCFA, antibiotic associated diarrhoea, colonic adenomas and cancerP. B. Mortensen and M. R. Clausen
26 In vivo and in vitro effects of SCFA on intestinal blood circulationF. V. Mortensen and H. Nielsen
27 SCFA and intestinal surgeryJ. L. Rombeau and K. J. Reilly and R. H. Rolandelli
28 SCFA as an energy source in the colonG. Livesey and M. Elia
29 SCFA and carbohydrate metabolismT. M. S. Wolever
30 SCFA and hepatic lipid metabolismD. L. Topping and I. Pant
31 SCFA and lipid metabolismJ. W. Anderson
32 Colonic SCFA in infants and childrenC. H. Lifschitz
33 Short-chain triglycerides in clinical nutritionS. J. DeMichele and M. D. Karlstad