Title:
Leucocyte adhesion
Series:
Current topics in membranes ; 64
Publication Information:
Burlington, MA : Academic Press, 2009
Physical Description:
xx, 397 p. : ill. (some col.) ; 24 cm.
ISBN:
9780123749093
Added Author:
Available:*
Library | Item Barcode | Call Number | Material Type | Item Category 1 | Status |
---|---|---|---|---|---|
Searching... | 30000010218831 | QP95 L47 2009 | Open Access Book | Book | Searching... |
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Summary
Summary
Leucocyte Adhesion provides a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. This volume provides a review of the latest developments in leukocyte adhesion. Regulation of cell adhesion is important for immune system function.
Table of Contents
Contributors | p. xi |
Foreword | p. xiii |
Previous Volumes in Series | p. xvii |
Section I Membrane Composition and Properties | |
Chapter 1 Membrane TethersRichard E. Waugh | |
I Overview | p. 3 |
II Introduction | p. 4 |
III Tethers Formed from Bilayer Vesicles | p. 6 |
IV Tetheis Formed from Red Blood Cells | p. 10 |
V Tethers from Neutrophils and Other Cells | p. 16 |
VI Implications for Cell Adhesion in the Vasculature | p. 19 |
VII Conclusion | p. 20 |
VIII Future Challenges | p. 21 |
References | p. 22 |
Chapter 2 Biomechanics of Leukocyte and Endothelial Cell SurfaceJin-Yu Shao | |
I Overview | p. 25 |
II Introduction | p. 26 |
III Surface Protrusion and Compression | p. 28 |
IV Flexural Stiffness of Leukocyte Microvilli | p. 32 |
V Membrane Tether Extraction | p. 33 |
VI Impact of Surface Protrusion and Tether Extraction on Leukocyte Rolling | p. 39 |
VII Concluding Remarks | p. 40 |
References | p. 41 |
Chapter 3 The Cytoskeleton and Deform ability of White Blood CellsDamir B. Khismatullin | |
I Overview | p. 47 |
II Introduction | p. 48 |
III Passive Deformation of the Cell Contributes to Cell Rolling | p. 50 |
IV Integrin Activation and Cell Arrest are Dependent on Cell Deformability | p. 57 |
V Firmly Adherent Cells Experience Active Deformation | p. 60 |
VI Cytoskeleton is the Source of Bulk Mechanical Properties of White Blood Cells | p. 63 |
VII White Blood Cell Deformability can be Measured by Several Rheological Techniques | p. 72 |
VIII Reduced Deformability of White-Blood Cells Leads to Pathologies | p. 88 |
IX Concluding Remarks | p. 90 |
References | p. 91 |
Section 2 Adhesion Molecules | |
Chapter 4 Activation of Leukocyte IntegrinsEun Jeong Park and Mototnu Shimaoka | |
I Overview | p. 115 |
II Leukocyte Integrins | p. 116 |
III Pathology of Integrin Function Deficiency | p. 117 |
IV Pathology Underlying the Aberrant Integrin Regulation | p. 118 |
V Structures of Integrin Heterodimers and Integrin Domains | p. 119 |
VI Conformational Changes in the ¿ and ß I-Domains | p. 120 |
VII Global Conformational Changes | p. 122 |
VIII Integrin Activation in Leukocyte-Endothelial Interactions | p. 123 |
IX Spatiotemporal Regulation of Integrin Activation | p. 125 |
X The Role of Integrins in the Interstitial Migration of Leukocytes | p. 126 |
XI Concluding Remarks | p. 127 |
References | p. 128 |
Chapter 5 Cytoskeletal Interactions with Leukocyte and Endothelial Cell Adhesion MoleculesFredrick M. Pavalko | |
I Overview | p. 134 |
II Introduction | p. 134 |
III Integrin Interactions with the Cytoskeleton | p. 134 |
IV Integrin Cytoplasmic Domain-Binding Proteins in Leukocytes | p. 138 |
V Selectin Interactions with the Cytoskeleton | p. 142 |
VI Immunoglobulin Superfamily Interactions with the Cytoskeleton | p. 146 |
VII Conclusions | p. 149 |
References | p. 149 |
Chapter 6 Membrane-Cytoskeletal Platforms for Rapid Chemokine Signaling to IntegrinsRonen Alon | |
I Overview | p. 158 |
II Introduction | p. 159 |
III Leukocyte Integrin Activation at Endothelial Contacts | p. 162 |
IV Signaling Events in Rapid Integrin Activation by GPCRs | p. 172 |
V Membranal Platforms for Integrin Activation by Chemokine Signals | p. 178 |
VI Priming of Integrins to Chemokine Signaling in Rolling Leukocytes | p. 181 |
VII Conclusions | p. 183 |
References | p. 184 |
Chapter 7 Biophysical Regulation of Selectin-Ligand Interactions Under FlowRodger P. McEver and Cheng Zhu | |
I Overview | p. 195 |
II Introduction | p. 196 |
III Selectins | p. 197 |
IV Selectin Ligands | p. 197 |
V Kinetic and Mechanical Parameters of Cell Tethering and Roiling Under Flow | p. 200 |
VI Force Free Kinetics and Affinity of Selectin-Ligand Interactions | p. 203 |
VII Mechanical Regulation of Selectin-Ligand Interactions | p. 204 |
VIII Flow-Enhanced Adhesion: The Shear Threshold Phenomenon | p. 208 |
IX Cellular Features that Modulate Selectin-Mediated Leukocyte Rolling | p. 211 |
X Conclusions | p. 214 |
References | p. 215 |
Chapter 8 Modeling Leukocyte RollingMaria K. Pospieszakka and Klaus Ley | |
I Overview | p. 221 |
II Motivation for Modeling Leukocyte Rolling | p. 222 |
III History of Modeling Leukocyte Rolling | p. 226 |
IV Development of a Leukocyte Rolling Model | p. 229 |
V Published Modeling Approaches | p. 254 |
VI Future Directions | p. 264 |
References | p. 266 |
Section 3 Active Role of Endothelial Cells | |
Chapter 9 Endothelial Adhesive Platforms Organize Receptors to Promote Leukocyte ExtravasationOlga Barreiro | |
I Overview | p. 277 |
II Introduction | p. 278 |
III The Emerging Concept of Endothelial Adhesive Platforms | p. 283 |
IV Concluding Remarks and Therapeutic Perspectives | p. 288 |
V Technical Appendix | p. 289 |
References | p. 291 |
Chapter 10 Transmigratory Cups and Invadosome-Like Protrusions: New Aspects of DiapedesisChristopher V. Carman | |
I Overview | p. 297 |
II Introduction | p. 298 |
III Endothelial Transmigratory Cups | p. 302 |
IV Leukocyte Invadosome-Like Protrusions | p. 316 |
V Summary and Perspective | p. 326 |
References | p. 327 |
Chapter 11 How Endothelial Cells Regulate Transendothelial Migration of Leukocytes: Molecules and MechanismsWilliam A. Midler | |
I Overview | p. 335 |
II Introduction | p. 336 |
III Endothelial Molecules Regulating Transmigration | p. 337 |
IV Mechanisms Regulating Transmigration | p. 342 |
V Epilogue: Unanswered Questions | p. 351 |
References | p. 351 |
Section 4 Methods | |
Chapter 12 Fluorescence Resonance Energy Transfer in the Studies of Integrin ActivationCraig T. Lefort and Minsoo Kim | |
I Overview | p. 360 |
II Fluorescent Biomolecules | p. 360 |
III Fluorescence Techniques | p. 366 |
IV Summary | p. 381 |
References | p. 382 |
Index | p. 389 |