Cover image for Hemodynamics and mechanobiology of endothelium
Title:
Hemodynamics and mechanobiology of endothelium
Personal Author:
Publication Information:
New Jersey : World Scientific, c2010
Physical Description:
viii, 370 p. : ill. ; 24 cm.
ISBN:
9789814280419

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30000010294287 QP105 H75 2010 Open Access Book Book
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Summary

Summary

The book represents a paradigm shift from the traditional static model of investigation of oxidative biology to the dynamic model of vascular oxidative stress. The investigation of vascular biology and cardiovascular medicine is made possible by the use of fluid dynamics, molecular signaling, genomic approach, tissue engineering, stem cell biology, and microfluidics. This is the first book to target a wide readership from academia to industry and government agencies in the field of cardiovascular diseases.


Table of Contents

Ian Campbell and W. Robert TaylorJun-Ichi Abe and Shi Pan and Brooke Krovic and Keigi FujiwaraJohn M. Tarbell and Eno E. EbongDaiji Kawanami and G. Brandon Atkins and Anne Hamik and Mukesh K. JainDaniel T. Sweet and Ellie TzimaB. R. Alevriadou and C. I. Jones and R. J. GiedtAnthony G. PasseriniLingfang Zeng and Anna Zampetaki and Qingbo XuTimothy M. Maul and Alejandro Nieponice and David A VorpBernard S. Salameh and Tamar L. Mirensky and Toshiharu Shinoka and Christopher K. BreuerJuan M. Jiménez and Peter F. DaviesR. Michael Gower and Scott SimonLisong Ai and Fei Yu and Zhouyuan Zhang and Tzung Hsiai
Prefacep. v
Chapter 1 Flow and Atherosclerosisp. 1
Chapter 2 Shear Stress-Mediated Signal Transductionp. 39
Chapter 3 Endothelial Glycocalyx Structure and Role in Mechanotransductionp. 69
Chapter 4 Role of Krüppel-Like Factors in Shear Stress-mediated Vasoprotectionp. 97
Chapter 5 Rho Family Small GTPases in Shear Stress Signalingp. 123
Chapter 6 Nitric Oxide and Endothelial Mitochondrial Function: Implications for Ischemia/Reperfusionp. 153
Chapter 7 Genomic Approaches to Endothelial Cell Phenotypingp. 179
Chapter 8 Endothelial Cell Proliferation and Differentiation in Response to Shear Stressp. 213
Chapter 9 Vascular Differentiation of Stem Cells by Mechanical Forcesp. 247
Chapter 10 Tissue Engineered Blood Vessels: From the Bench to the Bedside and Back Again (Development of a Vascular Conduit for Use in Congenital Heart Surgery)p. 271
Chapter 11 Design Implications for Endovascular Stents and the Endotheliump. 291
Chapter 12 Vascular Mimetic Microfluidic Systems for the Study of Endothelial Activation and Leukocyte Recruitment in Models of Atherogenesisp. 313
Chapter 13 Micro Shear Stress Sensors: From In Vitro to In Vivo Assessment of Inflammatory Responsesp. 331
Indexp. 361