Cover image for Micronutrients and brain health
Title:
Micronutrients and brain health
Series:
Oxidative stress and disease ; 26

Oxidative stress and disease ; 26.
Publication Information:
Boca Raton : CRC Press, c2010
Physical Description:
xxi, 434 p., [4] p. of plates : ill. (some col.) ; 27 cm.
ISBN:
9781420073515
Abstract:
"Under the direction of leading experts in oxidative stress, this book addresses cutting-edge areas of research regarding micronutrients and the brain. It discusses identification of brain-specific micronutrients that support function and molecular mechanisms underlying neuroprotectant activity. The book covers age-related metabolic pathways, mitochondrial nutrients, and neurodegeneration. Additional chapters cover flavonoids, cell signaling, and neuronal functions, as well as the role of choline, amino acids, metals, and other micronutrients in brain health and function. The text places a particular emphasis on lipoic acid, which is shown to be a therapeutic agent in neuropathologies."--Publisher's description.
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30000010270361 QP356.3 M535 2010 Open Access Book Book
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Summary

Summary

Micronutrients and Brain Health addresses cutting-edge research related to processes of oxidative stress that affect brain function, an area of increasing significance for those concerned and involved with public health and translational medicine. Edited by four leading micronutrient researchers, the book brings together the investigative work of more than 70 leading researchers from across the world. Chapters identify brain-specific micronutrients that support function as well as the molecular mechanisms underlying their neuroprotectant activity. These explore age-related metabolic pathways, mitochondrial nutrients, neurodegeneration and micronutrients, cell signaling, and neuronal functions. General chapters are included on brain structure, function, and metabolism, while several other chapters are devoted to the role of specific micronutrients. The book explores how brain micronutrients are found to be both metabolic and redox regulators, thereby establishing a cross-talk between the major pathways involved in modulation of cell signaling and gene expression. Specific areas of research covered include:

Uses of nutritional interventions to target age-related neuronal and behavioral deficits Effects of various micronutrients on Alzheimer's disease, including lipoic acid, green tea, and Ginkgo biloba extracts Nutrients specific to essential mitochondrial functions Cognitive and behavioral consequences of iron deficiency with specific emphasis on women of reproductive age Omega-3 fatty acids and their relation to brain function in the elderly Challenges inherent in the development of neuroprotective-neurorescue drugs

This book belongs to the groundbreaking CRC Press Series on Oxidative Stress and Disease. The series now includes more than two dozen volumes that address increasing evidence regarding the multiple ways that oxidative stress initiates and accelerates disease mechanisms. Most importantly, this book, like the series, offers invaluable information regarding nutritional and lifestyle choices, and pharmaceutical interventions that can be employed to prevent, control, and even ameliorate disease processes attributed to oxidative stress.


Table of Contents

Gary Fiskum and Robert E. RosenthalKristen Malkus and Elpida Tsika and Harry IschiropoulosLiqin Zhao and Roberta Diaz BrintonEmma Ramiro-Puig and Margarida Castell and Andrew McShea and George Perry and Mark A. Smith and Gemma CasadesusWycliffe O. Opii and Elizabeth HeadTomohiro Nakamura and Stuart A. LiptonLaura E. Murray-KolbAnita J. Fuglestad and Sara E. Ramel and Michael K. GeorgieffSu San Mok and Ashley I. BushAnnette E. Maczurek and Martina Krautwald and Megan L. Steele and Klaus Hager and Marlene Kenklies and Matt Sharman and Ralph Martins and Jürgen Engel and David Carlson and Gerald MünchGerardo G. Mackenzie and Patricia I. OteizaChandan K. Sen and Savita Khanna and Sashwati RoyJames A. Joseph and Barbara Shukitt-Hale and Lauren M. WillisPamela MaherJeremy P. E. Spencer and David Vauzour and Katerina Vafeiadou and Ana Rodriguez MateosRichard E. HartmanYves ChristenPaul E. MilburyBharat B. Aggarwal and Kuzhuvelil B. Harikumar and Sanjit DeyAndrea Lisa Holme and Shazib PervaizAntoni Camins and Carme Pelegri and Jordi Vilaplana and Rosa Cristofol and Coral Sanfeliu and Mercè PallàsRenã A. Sowell and Christopher D. Aluise and D. Allan ButterfieldJoyce C. McCann and Bruce N. AmesRicardo Uauy and Alan D. DangourOrly Weinreb and Tamar Amit and Silvia Mandel and Moussa B. H. YoudimRalf Dringen and Johannes HirrlingerRadovan Murín and Bernd Hamprecht
Series Prefacep. xi
Prefacep. xiii
The Editorsp. xv
Contributorsp. xvii
Chapter 1 Neuroprotection after Cardiac Arrest by Avoiding Acute Hyperoxia and by Antioxidant Genomic Postconditioningp. 1
Chapter 2 The Neuroprotective Role of Micronutrients in Parkinson's Diseasep. 13
Chapter 3 Phytoestrogens and Brain Healthp. 23
Chapter 4 Food Antioxidants and Alzheimer's diseasep. 41
Chapter 5 Micronutrient Antioxidants, Cognition, and Neuropathology: A Longitudinal Study in the Canine Model of Human Agingp. 51
Chapter 6 Excitatory Amino Acids, S-Nitrosylation, and Protein Misfolding in Neurodegenerative Disease: Protection by Memantine and NitroMemantine at NMDA-Gated Channelsp. 59
Chapter 7 Cognitive and Behavioral Consequences of Iron Deficiency in Women of Reproductive Agep. 79
Chapter 8 Micronutrient Needs of the Developing Brain: Priorities and Assessmentp. 93
Chapter 9 Therapeutics of Alzheimer's Disease Based on Metal Bioavailabilityp. 117
Chapter 10 Lipoic Acid as a Novel Treatment for Mild Cognitive Impairment and Early-Stage Alzheimer's Diseasep. 133
Chapter 11 Zinc and the Cytoskeleton in Neuronal Signalingp. 149
Chapter 12 Tocotrienol Neuroprotection: The Most Potent Biological Function of All Natural Forms of Vitamin Ep. 163
Chapter 13 Fruits, Nuts, and Brain Aging: Nutritional Interventions Targeting Age-Related Neuronal and Behavioral Deficitsp. 179
Chapter 14 Modulation of Multiple Pathways Involved in the Maintenance of Neuronal Function by Fisetinp. 189
Chapter 15 Dietary Flavonoids as Neuroprotective Agentsp. 207
Chapter 16 Actions of Bioactive Phytochemicals in Cell Function and Alzheimer's Disease Pathologyp. 225
Chapter 17 Does Ginkgo biloba Extract Exert an Effect on Alzheimer's Disease Progressionp. 243
Chapter 18 Green Tea Polyphenols Protect Neurons against Alzheimer's Disease and Parkinson's Diseasep. Baolu Zhao
Chapter 19 Transport of Flavonoids into the Brainp. 265
Chapter 20 Prevention and Treatment of Neurodegenerative Diseases by Spice-Derived Phytochemicalsp. 281
Chapter 21 Neurohormetic Properties of the Phytochemical Resveratrolp. 309
Chapter 22 Sirtuin and Resveratrolp. 329
Chapter 23 Acetyl-l-Carnitine and Ferulic Acid Action in Aging and Neurodegenerative Diseasesp. 341
Chapter 24 Evidence Required for Causal Inferences about Effects of Micronutrient Deficiencies during Development on Brain Health: DHA, Choline, Iron, and Vitamin Dp. 355
Chapter 25 Omega-3 Fatty Acids and Brain Function in Older Peoplep. 365
Chapter 26 Iron and Monoamine Oxidase in Brain Function and Dysfunction: Development of Neuroprotective-Neurorescue Drugsp. 377
Chapter 27 Antioxidative Defense of Brain Microglial Cellsp. 393
Chapter 28 Branched-Chain Amino Acids and Brain Metabolismp. 403
Indexp. 417