Title:
Biocatalyst design for stability and specificity
Conference Author:
Series:
ACS symposium series; 516
Publication Information:
Washington, DC : American Chemical Society, 1993
ISBN:
9780841225183
General Note:
Developed from a symposium sponsored by the Division of Biochemical Technology of the American Chemical Society at the Fourth Chemical Congress of North America (202nd National Meeting of the American Chemical Society), New York, New York, August 25-30, 1991
Added Corporate Author:
Added Conference Author:
Available:*
Library | Item Barcode | Call Number | Material Type | Item Category 1 | Status |
|---|---|---|---|---|---|
Searching... | 30000003033234 | TP248.65.E59 C43 1993 | Open Access Book | Proceedings, Conference, Workshop etc. | Searching... |
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Summary
Summary
Highlights the diversity of approaches used in understanding the function of proteins and how this understanding is applied to improving protein design for biotechnology applications. Reports on the status of current research into the interactions underlying protein stability. Emphasizes the renaturation of functional properties from the aggregated state. Covers the relationship between protein structure and function and the design of artificial multifunctional proteins by genetic technology. Reviews recent advances in the improvement of cellulase design through recombinant technology. Examines the use of chemical modification to improve enzymes.
Table of Contents
| Effects of Mutations on Thermodynamic Properties of ProteinsJ.M. Sturtevant |
| Contribution of Hydrogen Bonding andthe Hydrophobic Effect to Conformational Stability of Ribonuclease T1C.N. Pace and K. Gajiwala and B.A. Shirley |
| Protein Structure and Stability Assessment by Circular DischroismSpectroscopyR. Jaenicke and M.C. Manning |
| Structure--Function Relationship of Hyperthermophilic EnzymesJ.B. Bjarnason and B. Asgeirsson and J.W. Fox |
| Psychrophilic Proteinases fromAtlanticCodJ.O. Bkaer and M.E. Himmel |
| Thermal and pH Stress in Thermal Denaturation of Trichoderma reesei Cellobiohydrolase I: Supporting Evidence for a Two-Transition ModelP. Umana and J.T. Kellis, Jr and F.H. Arnold |
| Recombinant Protein Stabilizationthrough Engineered Metal-Chelating SitesF.H. Arnold and K. Chen and C. Economou and W. Chen and P. Martinez and K.P. Yoon and M. VanDam |
| Engineering Nonaqueous Solvent-Compatible EnzymesR. Wetzel and B.A. Chrunyk |
| Mutational Effects on Inclusion Body FormationP. Valax and G. Georgiou |
| Characterization and Refolding of b-Lactamase Inclusion Bodies in Escherichia coliA.A. Gatenby and G.K. Donaldson and F. Baneyx and G.H. Lorimer and P.V. Viitanen and S M.van der Vies |
| Participation of GroE Heat Shock Proteins in Polypeptide FoldingJ.L. Cleland and D.I.C. Wang |
| Cosolvent Effects on Refolding and AggregationP.M. Horowitz |
| Facilitation of Protein Folding and the Reversibility ofDenaturationL. Bulow |
| Artificial Bifunctional Enzymes: A Tool To Improve Consecutive EnzymeReactions and Cell MetabolismE. Ong and J.M. Greenwood and N.R. Gilkes and R.C. Miller, Jr and R.A.J. Warren and D.G.Kilburn |
| Proteins Designed for Adherence to CelluloseM.E. Wales and C.J. Strang and R. Swanson and J.R. Wild |
| Modification of Regulatory |
| Communication in Aspartate TranscarbamoylaseA.E. Thigpen and C.K. Barlowe and D.R. Appling |
| C1-Tetrahydrofolate Synthase:Dissection of Active Site and Domain Structure by Protein EngineeringC. Barnett and L. Sumner and R. Berka and S. Shoemaker and H. Berg and M. Gritzli and R.Brown |
| Properties of Native and Site-Mutagenized Cellobiohydrolase IIT. Fowler |
| Recombinant b-Glucosidase of Trichoderma reeseiD.B. Wilson |
| Structure-Function Relationships in Cellulase GenesJ.H D. Wu |
| Clostridium thermocellum Cellulosome: New Mechanistic Concept forCellulose DegradationS.S. Wong and M. Losiewicz and L.-J. C. Wong |
| Protein Chemical Cross-Linking:Implications for Protein StabilizationT.J.A. Johnson |
| Glutaraldehyde Cross-Linking: Fast and Slow ModesA. Sadana and R.R. Raju |
| Chemical Modification: Effect on Enzyme Activities andStabilitiesM.N. Gupta |
| Cross-Linking Techniques: Applications to Enzyme and Protein |
| Stabilization and Bioconjugate Preparation |
