Nanostructure design : methods and protocols

As one of the fastest growing fields of research in the 21st century, nanotechnology is sure to have an enormous impact on many aspects of our lives. Nanostructure Design: Methods and Protocols serves as a major reference for theoretical and experimental considerations in the design of biological and bio-inspired building blocks, the physical characterization of the formed structures, and the development of their technical applications. The chapters contributed by leading experts are divided into two sections, the first of which covers experimental aspects of nanostructure design and the second delves into computational methods. As a volume of the highly successful Methods in Molecular Biology(tm) series, this collection pulls together cutting-edge protocols, written in a step-by-step, readily reproducible format certain to guide researchers to the desired results.

Comprehensive and essential, Nanostructure Design: Methods and Protocols uses biological principles and vehicles on design to aid scientists in the great challenges still ahead.

Charlotte Vendrely and Christian Ackerschott and Lin Romer and Thomas ScheibelKaterina Papanikolopoulou and Mark J. van Raaij and Anna MitrakiMaxim G. Ryadnov and David Papapostolou and Derek N. WoolfsonJoseph M. Slocik and Rajesh R. NaikRadhika P. Nagarkar and Joel P. SchneiderWeian Zhao and Michael A. Brook and Yingfu LiBruce A. Shapiro and Eckart Bindewald and Wojciech Kasprzak and Yaroslava YinglingIdit Buch and Chung-Jung Tsai and Haim J. Wolfson and Ruth NussinovGiovanni Bellesia and Sotiria Lampoudi and Joan-Emma SheaMaarten G. Wolf and Jeroen van Gestel and Simon W. de LeeuwAleksei Aksimentiev and Robert Brunner and Jordi Cohen and Jeffrey Comer and Eduardo Cruz-Chu and David Hardy and Aruna Rajan and Amy Shih and Grigori Sigalov and Ying Yin and Klaus SchultenUgur Emekli and K. Gunasekaran and Ruth Nussinov and Turkan Haliloglu

Preface	p. v
Contributors	p. xi
Part I Experimental Approach
1 Molecular Design of Performance Proteins With Repetitive Sequences: Recombinant Flagelliform Spider Silk as Basis for Biomaterials	p. 3
2 Creation of Hybrid Nanorods From Sequences of Natural Trimeric Fibrous Proteins Using the Fibritin Trimerization Motif	p. 15
3 The Leucine Zipper as a Building Block for Self-Assembled Protein Fibers	p. 35
4 Biomimetic Synthesis of Bimorphic Nanostructures	p. 53
5 Synthesis and Primary Characterization of Self-Assembled Peptide-Based Hydrogels	p. 61
6 Periodic Assembly of Nanospecies on Repetitive DNA Sequences Generated on Gold Nanoparticles by Rolling Circle Amplification	p. 79
Part II Computational Approach
7 Protocols for the In Silico Design of RNA Nanostructures	p. 93
8 Self-Assembly of Fused Homo-Oligomers to Create Nanotubes	p. 117
9 Computational Methods in Nanostructure Design: Replica Exchange Simulations of Self-Assembling Peptides	p. 133
10 Modeling Amyloid Fibril Formation: A Free-Energy Approach	p. 153
11 Computer Modeling in Biotechnology: A Partner in Development	p. 181
12 What Can We Learn From Highly Connected [beta]-Rich Structures for Structural Interface Design?	p. 235
Index	p. 255

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