CompLife 2007 : 3rd International Symposium on Computational Life Science, Utrecht, The Netherlands, 4-5 October 2007

The focus of the symposium is on computational methods for modeling, analysis, and exploration of all aspects of life sciences, ranging from effects on the molecular level to complex interactions networks. Of prime importance for this truly interdisciplinary event is the integration of the three disciplines: Computer Science, Biology, and Chemistry. These proceedings contains contributions regarding applications aspects as well as new theoretical developments.

K. Fraser and Z. Wang and Y. Li and P. Kellam and X. LiuE. de Jong and L. Franke and A. SiebesP. S. McCormick and P. Murray and R. C. GlenE. Peeling and A. TuckerR. Brijder and H. J. HoogeboomK. Yu and V. Vinciotti and X. Liu and P. A. C. 't HoenA. Larhlimi and A. BockmayrY. Sanchez-Dehesa and G. Beslon and J.-M. PenaS. M. Djaouti and A. Koudache and A. BoudaiebA. A. FaisalL. Hofto and M. Hofto and J. Cross and M. CafieroR. Hussong and A. Tholey and A. HildebrandtC. H. Jensen and D. Nerukh and R. C. GlenT. Schroeter and A. Schwaighofer and S. Mika and A. Ter Laak and D. Suelzle and U. Ganzer and N. Heinrich and K.-R. MullerM. R. de Jonge and H. M. Vinkers and J. H. van Lenthe and F. Daeyaert and I. J. Bush and H. J. J. van Dam and P. Sherwood and M. F. Guest

Preface	p. vii
Genomics
Improving Microarray Expressions with Recalibration	p. 3
On the Measurement of Genetic Interactions	p. 16
Cluster Assisted Mixed Effect Models (CAMM) for the Identification of Differentially Expressed Genes	p. 26
Consensus Gene Regulatory Networks: Combining Multiple Microarray Gene Expression Datasets	p. 38
Using Sorting by Reversal: Breakpoint Graph for Gene Assembly in Ciliates	p. 50
Bayesian Median Regression for Temporal Gene Expression Data	p. 60
Systems Biology
Minimal Direction Cuts in Metabolic Networks	p. 73
Modeling Evolution of Regulatory Networks in Artificial Organisms	p. 87
Medical Informatics
Polarimetric Images Segmentation for Lesion Detection	p. 101
Studying Channelopathies at the Functional Level Using a System Identification Approach	p. 113
Using Simple Molecular Orbital Calculations to Predict Disease: Fast DFT Methods Applied to Enzymes Implicated in PKU, Parkinson's Disease and Obsessive Compulsive Disorder	p. 127
Efficient Analysis of Mass Spectrometry Data Using the Isotope Wavelet	p. 139
Calculating Mean First Passage Times from Markov Models of Proteins	p. 150
Predicting Error Bars for QSAR Models	p. 158
Ab Initio Potential Grid Based Docking: From High Performance Computing to In Silico Screening	p. 168
Author Index	p. 179

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Table of Contents