Title:
Biosensors and molecular technologies for cancer diagnostics
Series:
Series in sensors
Sensors series.
Publication Information:
Boca Raton : Taylor & Francis/CRC Press, 2012.
Physical Description:
xxii, 820p.: ill. ; 26cm.
ISBN:
9781439841655
Available:*
Library | Item Barcode | Call Number | Material Type | Item Category 1 | Status |
|---|---|---|---|---|---|
Searching... | 30000010242626 | RC270 B56 2012 | Open Access Book | Book | Searching... |
On Order
Summary
Summary
Bridging the gap between research and clinical application, Biosensors and Molecular Technologies for Cancer Diagnostics explores the use of biosensors as effective alternatives to the current standard methods in cancer diagnosis and detection. It describes the major aspects involved in detecting and diagnosing cancer as well as the basic elements of biosensors and their applications in detection and diagnostics.
The book addresses cancer molecular diagnostics, including genomic and proteomic approaches, from the perspective of biosensors and biodetection. It explains how to measure and understand molecular markers using biosensors and discusses the medical advantages of rapid and accurate cancer diagnostics. It also describes optical, electrochemical, and optomechanical biosensor technologies, with a focus on cancer analysis and the clinical utility of these technologies for cancer detection, diagnostics, prognostics, and treatment.
Making biosensor technology more accessible to molecular biologists, oncologists, pathologists, and engineers, this volume advances the integration of this technology into mainstream clinical practice. Through its in-depth coverage of a range of biosensors, the book shows how they can play instrumental roles in the early molecular diagnosis of cancer.
Author Notes
Keith E. Herold is an associate professor in the Fischell Department of Bioengineering at the University of Maryland. A fellow of the ASME, Dr. Herold has over 10 years of experience in the analysis and testing of biosensor systems. His current research interests include bioMEMS, microfluidic systems for bioanalytical assays, and heat and mass transfer in bioengineering.
Avraham Rasooly is the chief of the Disparities Research Branch at the National Cancer Institute and a member of the Division of Biology in the Center for Devices and Radiological Health at the U.S. Food and Drug Administration.
Table of Contents
| Preface | p. xi |
| Contributors | p. xv |
| Part I Introduction | |
| 1 Cancer and the Use of Biosensors for Cancer Clinical Testing | p. 3 |
| Part II Optical Technologies for Cancer Detection and Diagnostics: Surface Plasmon Resonance | |
| 2 Surface Plasmon Resonance Biosensor Based on Competitive Protein Adsorption for the Prognosis of Thyroid Cancer | p. 43 |
| 3 Surface Plasmon Resonance Analysis of Nanoparticles for Targeted Drug Delivery | p. 55 |
| 4 Dual-Functional Zwitterionic Carboxybetaine for Highly Sensitive and Specific Cancer Biomarker Detection in Complex Media Using SPR Biosensors | p. 69 |
| 5 Surface Plasmon Resonance (SPR) and ELISA Methods for Antibody Determinations as Tools for Therapeutic Monitoring of Patients with Acute Lymphoblastic Leukemia (ALL) after Native or Pegylated Escherichia coli and Erwinia chrysanthemi Asparaginases | p. 89 |
| Part III Optical Technologies for Cancer Detection and Diagnostics: Evanescent Wave and Waveguide Biosensors | |
| 6 Photonic Biochip Sensor System for Early Detection of Ovarian Cancer | p. 111 |
| 7 Label-Free Optofluidic Ring Resonator Biosensors for Sensitive Detection of Cancer Biomarkers | p. 125 |
| 8 Resonant Waveguide Grating Biosensor for Cancer Signaling | p. 141 |
| 9 Optical Waveguide-Based Biosensors for the Detection of Breast Cancer Biomarkers | p. 155 |
| 10 Label-Free Resonant Waveguide Grating (RWG) Biosensor Technology for Noninvasive Detection of Oncogenic Signaling Pathways in Cancer Cells | p. 171 |
| Part IV Optical Technologies for Cancer Detection and Diagnostics: Spectrometry for Cancer Analysis | |
| 11 Noninvasive and Quantitative Sensing of Tumor Physiology and Function via Steady-State Diffuse Optical Spectroscopy | p. 187 |
| 12 Noble Metal Nanoparticles as Probes for Cancer Biomarker Detection and Dynamic Distance Measurements in Plasmon Coupling Microscopy | p. 209 |
| 13 Cost-Effective Evaluation of Cervical Cancer Using Reflectance and Fluorescence Spectroscopy | p. 229 |
| Part V Optical Technologies for Cancer Detection and Diagnostics: Optical Imaging for Cancer Analysis | |
| 14 Location and Biomarker Characterization of Circulating Tumor Cells | p. 257 |
| 15 High-Resolution Microendoscopy for Cancer Imaging | p. 275 |
| 16 Lensless Fluorescent Imaging on a Chip: New Method toward High-Throughput Screening of Rare Cells | p. 293 |
| 17 Multiphoton Luminescence from Gold Nanoparticles as a Potential Diagnostic Tool for Early Cancer Detection | p. 307 |
| 18 Early Detection of Oral Cancer Using Biooptical Imaging Technologies | p. 323 |
| 19 Tactile Sensing and Tactile Imaging in Detection of Cancer | p. 337 |
| Part VI Optical Technologies for Cancer Detection and Diagnostics: Fluorescence, Luminescence, Refractive Index Detection Technologies | |
| 20 Biomechanics-Based Microfluidic Biochip for the Effective Label-Free Isolation and Retrieval of Circulating Tumor Cells | p. 355 |
| 21 Sensitive Mesofluidic Immunosensor for Detection of Circulating Breast Cancer Cells onto Antibody-Coated Long Alkylsilane Self-Assembled Monolayers | p. 375 |
| 22 Micropatterned Biosensing Surfaces for Detection of Cell-Secreted Inflammatory Signals | p. 389 |
| 23 Quantum Dots Nanosensor Analysis of Tumor Cells | p. 405 |
| 24 Compact Discs Technology for Clinical Analysis of Drugs | p. 417 |
| 25 Colorimetric Multiplexed Immunoassay for Sequential Detection of Tumor Markers | p. 441 |
| 26 Molecular Pincers for Detecting Cancer Markers | p. 455 |
| 27 Fluorescent Nanoparticles for Ovarian Cancer Imaging | p. 465 |
| 28 Detection of Cancer-Associated Autoantibodies as Biosensors of Disease by Tumor Antigen Microarrays | p. 483 |
| Part VII Optical Technologies for Cancer Detection and Diagnostics: Photoacoustic for Cancer Analysis | |
| 29 Detecting Circulating Melanoma Cells in Blood Using Photoacoustic Flowmetry | p. 505 |
| Part VIII Electrochemical Biosensors | |
| 30 Self-Contained Enzymatic Microassay Biochip for Cancer Detection | p. 517 |
| 31 Electrochemical Protein Chip for Tumor Marker Analysis | p. 541 |
| 32 Characterization of Cancer Cells Using Electrical Impedance Spectroscopy | p. 559 |
| 33 Electrochemical Immunosensor for Detection of Proteic Cancer Markers | p. 573 |
| 34 Electrochemical Biosensors for Measurement of Genetic Biomarkers of Cancer | p. 591 |
| 35 Microimpedance Measurements for Cellular Transformation and Cancer Treatments | p. 609 |
| 36 Multiplexing Electrochemical Sensor for Salivary Cancer Biomarker Detection | p. 629 |
| 37 Microelectrode Array Analysis of Prostate Cancer | p. 643 |
| 38 Graphene-Based Electrochemical Immunosensor for the Detection of Cancer Biomarker | p. 657 |
| 39 Label-Free Electrochemical Sensing of DNA Hybridization for Cancer Analysis | p. 671 |
| 40 Electrochemical Biosensor for Detection of Chronic Myelogenous Leukemia and Acute Promyelocytic Leukemia | p. 693 |
| Part IX Electronic and Magnetic Technologies for Cancer Analysis | |
| 41 Nanowire Transistor-Based DNA Methylation Detection | p. 713 |
| 42 Cancer Cell Detection and Molecular Profiling Using Diagnostic Magnetic Resonance | p. 731 |
| 43 Field Effect Transistor Nanosensor for Breast Cancer Diagnostics | p. 747 |
| 44 Measuring the Electric Field in Skin to Detect Malignant Lesions | p. 765 |
| Part X Thermometric Sensing | |
| 45 Next Generation Calorimetry Based on Nanohole Array Sensing | p. 777 |
| Part XI Cantilever-Based Technology | |
| 46 Microcantilever Biosensor Array for Cancer Research: From Tumor Marker Detection to Protein Conformational State Analysis | p. 803 |
| Index | p. 815 |
