Apoptosis, senescence and cancer

Apoptosis, Senescence and Cancer provides insight into established practices and research into apoptosis and senescence by thoroughly examining novel and emerging techniques and research in the fields of cell death pathways, senescence growth arrest, drugs and resistance, DNA damage response, and other topics which still hold mysteries for researchers.

The volume is divided into six easy to follow sections. The first is Apoptosis and Alternative Modes of Cell Death, followed by chapters on Telomeres and Telomerase, Senescence, Genomic Instability and Tumorigenesis. The third part covers DNA Damage Response, Signaling Pathways and Tumorigenesis, while the fourth delves into Resistance and Sensitization. The book concludes with Established Cancer Therapies and a section which looks toward the future with Recent and Developing Cancer Therapies.

In total, this volume provides basic scientists and clinicians with a deeper and more complete understanding of the cellular responses of malignancies which may determine the effectiveness of treatment, both in the initial stages of the disease as well as in disease recurrence.

Author Notes

Lisa M. Greenhill is the Associate Executive Director for Institutional Research and Diversity for the Association of American Veterinary Medical Colleges. Her work primarily focuses on the ongoing development and implementation of the DVM: DiVersity Matters initiative at the national and local levels as well as promoting the veterinary medical profession within communities of color. Greenhill is the recipient of the Emerging Leader Award from the National Association of Minority Medical Educators, Inc.

Kauline Cipriani Davis is the Director of Diversity Initiatives at the Purdue School of Veterinary Medicine. She is responsible for developing, implementing and coordinating initiatives to enhance diversity and inclusiveness.

Patricia M. Lowrie is the Assistant to the Dean in the College of Veterinary Medicine and is also the Director of the Women's Resource Center at Michigan State University. She is the recipient of the MSU University Diversity Award, and she was recently recognized by the Association of American Veterinary Colleges for her contributions to veterinary medical education. Lowrie currently is a senior fellow at the Association of American Colleges and Universities and serves as chairperson of the advisory board for Campus Women Lead.

Sandra F. Amass is the Associate Dean for Engagement and a professor of veterinary clinical sciences at the Purdue School of Veterinary Medicine. She is a co-PI on the Fat Dogs and Coughing Horses Program, a cooperative effort funded by NIH/NCRR/SEPA to develop educational programs for P-12 students.

Scott H. KaufmannM. Stacey Ricci and Wafik S. El-DeiryBradly G. Wouters and Roland K. ChiuFiorenza Ianzini and Michael A. MackeyMojgan Djavaheri-Mergny and Joelle Botti and Patrice CodognoDavid J. McConkey and Victor BondarJay E. Johnson and Dominique BroccoliRuben D. RamirezRichard Possemato and William C. HahnJohn P. MurnaneAude Dupre and Jean GautierKirsteen H. Maclean and John L. ClevelandFatouros Chronis and Emmy P. RogakouLawrence F. PovirkPaul Dent and David T. Curiel and Paul B. FisherMyles C. CabotDebra L. Smith and Laura K. Nolden and Gordon B. Mills and Yiling LuGregory W. Allen and Paul M. HarariJanet A. HoughtonOlivier Sordet and Yves Pommier and Eric SolaryAnnette K. Larsen and Andrzej SkladanowskiJan M. Woynarowski and Barbara A. WoynarowskaLaura E. KleinMichael DeiningerRichard R. Furman and John P. Leonard and Julian Decter and Morton ColemanJennifer A. Doll and Jennifer E. Hobbs and Gerald A. SoffNancy L. Oleinick and Rachel L. Morris and Anna-Liisa NieminenSimone Fulda and Klaus-Michael Debatin

Preface	p. v
Contributors	p. xi
Introduction and Overview	p. xv
Part I Apoptosis and Alternative Modes of Cell Death
1 The Intrinsic Pathway of Apoptosis	p. 3
2 The Extrinsic Pathway of Apoptosis	p. 31
3 Evaluating the Importance of Apoptosis and Other Determinants of Cell Death and Survival	p. 55
4 Mitotic Catastrophe	p. 73
5 Autophagy and Autophagic Cell Death	p. 93
6 Regulation and Function of Detachment-Induced Cell Death (Anoikis) in Cancer Progression and Metastasis	p. 109
Part II Telomeres and Telomerase, Senescence, Genomic Instability, and Tumorigenesis
7 Structure and Function of the Telomere	p. 125
8 Overview of Senescence	p. 145
9 Contributions of Telomerase to Tumorigenesis	p. 159
10 The Role of Telomeres in Genomic Instability	p. 173
Part III DNA Damage Response, Signaling Pathways, and Tumorigenesis
11 Overview of the DNA Damage Checkpoint: ATM and ATR	p. 193
12 Interactions Between Myc- and Cyclin-Dependent Kinase Inhibitors in Cancer	p. 223
13 Interplay Between [gamma]H2AX and 53BP1 Pathways in DNA Double-Strand Break Repair Response	p. 243
14 DNA-Dependent Protein Kinase in Repair, Apoptosis, Telomere Maintenance, and Chemotherapy	p. 265
Part IV Resistance and Sensitization
15 Resistance/Signaling Pathways	p. 281
16 Ceramide and Multidrug Resistance	p. 299
17 Chemo- and Radiosensitization Through Inhibition of PI3K/Akt Signaling	p. 313
18 The Advancement of Epidermal Growth Factor Receptor Inhibitors in Cancer Therapy	p. 335
Part V Established Cancer Therapies
19 Antimetabolites	p. 361
20 Topoisomerase I Poisons and Apoptotic Topoisomerase I-DNA Complexe	p. 383
21 Perturbations of Cellular Functions by Topoisomerase II Inhibitors: All Roads Lead to Cell Death?	p. 407
22 The Significance of Poly-Targeting in Apoptosis Induction by Alkylating Agents and Platinum Drugs	p. 423
23 Contributions of Apoptosis and Senescence to Cytotoxicity Produced by Microtubule-Stabilizing Agents	p. 465
24 Tyrosine Kinase Inhibitors	p. 477
Part VI Recent and Developing Cancer Therapies
25 Monoclonal Antibodies in Lymphomas	p. 511
26 Role of Apoptosis in Anti-Angiogenic Cancer Therapies	p. 537
27 Photodynamic Therapy-Induced Apoptosis	p. 557
28 Modulation of TRAIL Signaling for Cancer Therapy	p. 579
Index	p. 593

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Table of Contents