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Summary
Summary
Advances in Synthetic Organic Chemistry and Methods Reported in US Patents provides synthetic guidelines for preparing current and commercially significant organic compounds, derivatives, and intermediates as reported in issued US Patents. Industries surveyed include agrochemical, cosmetics and personal care products. Each entry contains extensive information such as explicit laboratory directions for preparing all chemical intermediates and characterization data. Furthermore, product optimization studies, industrial preparation, and new synthetic methods have been included for selected entries, as well as projected research directions for future product development. In Advances in Synthetic Organic Chemistry and Methods Reported in US Patents the author's practical approach enables readers to identify research and market trends, and stay up-to-date on current developments in the field.
Table of Contents
Introduction | p. xvii |
Acids and Derivatives | p. 1 |
Aromatic Carboxylic Acid Derivatives | p. 1 |
Azinyloxy, and Phenoxy-Diaryl-Carboxylic Acid Derivatives, Their Preparation and Use as Mixed ETA/ETB Endothelin Receptor Antagonists | p. 5 |
Cinnamic Acid Derivatives | p. 8 |
Compounds Derived from Benzoic Acid Esters, Composition Containing Said Compounds and Use Thereof | p. 12 |
1,2-Diarylmethylene Derivatives, Their Methods of Preparation, and Their Uses in Therapeutics | p. 14 |
Geranic Acid Derivatives | p. 18 |
Halogenated Cinnamic Acids and Esters Thereof, Processes for the Preparation Thereof and Halogenated Aryldiazonium Salts | p. 20 |
Halogenation Catalyst | p. 22 |
Method for Producing Alkoxy Malonic Acid Dinitriles | p. 24 |
Phosphonosuccinic Acid Derivatives, Processes for Their Preparation and Medicaments Containing These Compounds | p. 26 |
Preparation of Cyclohexane Carboxylate Derivatives | p. 28 |
Water Soluble Fullerenes with Antiviral Activity | p. 33 |
Alcohols | p. 36 |
Butyne Diol Derivatives | p. 36 |
1,2-Dithin Antiinfective Agents | p. 41 |
Oligiocycloalkanoid Compounds and Methods of Use | p. 44 |
Polymers with Controlled Physical State and Bioerodibility | p. 48 |
4-Quinolinemethanol Derivatives as Purine Receptor Antagonists | p. 50 |
Synthesis of 5-Decenyl Acetate and Other Pheromone Components | p. 53 |
Aldols | p. 55 |
Stereospecific Synthesis of Aldols | p. 55 |
Aldehydes | p. 58 |
Process for Selective Catalytic Oxidation of Olefins to Aldehydes, Ketones with Cleavage of C=C Bonds | p. 58 |
Alkenes | p. 60 |
Carbonyl-Containing Compounds | p. 60 |
Alkynes | p. 62 |
Diaryl-enynes | p. 62 |
DNA-Cleaving Anti-Tumor Agents | p. 66 |
Amides | p. 70 |
Adamantane Derivatives | p. 70 |
o-Anisamide Derivatives | p. 73 |
Benzamide Analogues Useful as PARP (ADP-Ribosyltransferase, ADPRT) DNA Repair Enzyme Inhibitors | p. 76 |
Carboxamide Compositions, Methods, and Compositions for Inhibiting PARP Activity | p. 79 |
Heterocyclic Amides | p. 82 |
Phosphoramide Compounds | p. 87 |
Amines | p. 90 |
Aminophenyl Ketones Derivatives and a Method for the Preparation Thereof | p. 90 |
Arylamine Synthesis | p. 94 |
Fungicidal Spirocyclic Amines | p. 97 |
Method for Producing Propargylamine Compounds | p. 101 |
One Pot Process for the Preparation of 1-[2-Methylamino-(4-Methoxyphenyl)-Ethyl]Cyclohexanol | p. 104 |
Organic Electroluminescence Device and Phenylenediamine Derivative | p. 106 |
Process for Preparing N-Substituted Hydroxylamines and Salts Thereof | p. 110 |
Sodium Channel Modulators | p. 112 |
Substituted 2-Aminoalkyl 1,4-Diaminobenzene Compounds and Oxidation Dye Precursor Containing the Same | p. 115 |
Aminoacids | p. 117 |
Aminoindanes | p. 117 |
Aminopropylphosphinic Acids | p. 120 |
Cyclic Aminoacids and Derivatives Thereof Useful as Pharmaceutical Agents | p. 122 |
Isocyanoalkyl, Carbonic Acid Derivatives, Their Conversion into Secondary Amidoalkyl Carbonic Acid Derivatives by Isocyanide Multicomponent Reactions, as well as these Secondary Amidoalkyl Carbonic Acid Derivatives | p. 125 |
Spirodiamino Acid Scaffold for Combinatorial Synthesis | p. 128 |
Anthracenones | p. 132 |
10-Substituted 1,8-Dihydroxy-9(10H) Anthracenone Pharmaceuticals | p. 132 |
Aza and Diaza Bi- and Tricyclics | p. 136 |
Bi- and Tri-Cyclic Aza Compounds and Their Uses | p. 136 |
Certain Tricyclic Substituted Diazabicyclo[3.2.1]octane Derivatives | p. 141 |
Dopamine Transporter Imaging Agent | p. 144 |
N-Alkyl and N-Acyl Derivatives of 3,7-Diazabicyclo-[3.3.1] Nonanes and Selected Salts Thereof as Multiclass Antirrhythmic Agents | p. 147 |
Process for the Manufacture of Tropenol | p. 150 |
Aza Benzazolium Salts | p. 153 |
Aza-Benzazolium Containing Cyanine Dyes | p. 153 |
Aza-Dihydroquinoxaline | p. 156 |
8-Aza, 6-Aza and 6,8-Diazo-1,4-dihydroquinoxaline-2,3-diones and the Use Thereof as Antagonists for the Glycine/NMDA Receptor | p. 156 |
Aza-Indolyls | p. 159 |
Aza-Indolyl Derivatives for Treating Obesity | p. 159 |
Aza-Oxindoles | p. 162 |
Substituted Aza-Oxindole Derivatives | p. 162 |
Azides | p. 165 |
Stereoselective Ring Opening Reactions | p. 165 |
Aziridines/Diazirines | p. 170 |
Diazirine Derivatives of Aromatic Heterocyclic Compounds | p. 170 |
Preparation of N-Arylmethyl Aziridine Derivatives 1,4,7,10-Tetraazacyclododecane Derivatives Obtained Therefrom and N-Arylethyl-ethanolamine Sulfonate Esters as Intermediates | p. 173 |
Process for Producing Aziridine Compounds | p. 176 |
Benzodiazopines | p. 178 |
Benzodiazepines | p. 178 |
Benzoxazoles | p. 182 |
Benzoxazoles | p. 182 |
Benzopyrans | p. 186 |
Benzopyran Derivatives | p. 186 |
Benzothiophenes | p. 190 |
Pentacyclic Compounds, Intermediates, Processes, Compositions, and Methods | p. 190 |
Benzotriazole | p. 195 |
Method of Synthesizing t-Amido-Substituted 2-(2-Hydroxyphenyl)benzotriazole Compounds in a One-Step Process | p. 195 |
Carbamates/Ureas | p. 199 |
Herbicidal Sulfonylureas, Their Preparation and Use | p. 199 |
Process for the Preparation of Aminocarbonyl Derivatives of Geneseroline Having Selective Brain Anticholinesterase Activity | p. 202 |
Catalysis | p. 205 |
Highly Reactive Form of Copper and Reagents Thereof | p. 205 |
Lewis Acid Catalyst Composition | p. 208 |
Cumulenes | p. 211 |
Aromatic Allene Compounds of the Formula (CH[subscript 2] = CH-O)[subscript n]-R-(A)[subscript m] in Which R is an Aromatic Group and Preparation Thereof | p. 211 |
Preparation of Unsaturated Ketones | p. 214 |
(S)-4-Amino-Hepta-5,6-Dienoic Acid and Intermediates Thereof | p. 217 |
Cyanohydrins | p. 220 |
Method for the Stereoselective Production of Substituted Cyclohexylanhydrins | p. 220 |
Cyclodextrane/Dextrane | p. 223 |
Conjugation of Biomolecules Using Diels-Adler Cycloaddition | p. 223 |
Nohr-McDonald Elimination Reaction | p. 227 |
Cyclopentadiene | p. 230 |
Cyclopentadienyl Derivatives and Process for Their Preparation | p. 230 |
Cyclopropanes | p. 233 |
Aryl Phenylcyclopropyl Sulfide Derivatives and Their Use as Cell Adhesion Inhibiting Anti-Inflammatory and Immune Suppressive Agents | p. 233 |
Cyclic Compounds Having a Cycloalkylene Chain | p. 236 |
2-Hydroxymethylcyclopropylidene-Methylpurines and -Pyrimidines as Antiviral Agents | p. 240 |
Process of Producing Cyclopropanecarboxylate Compounds | p. 245 |
Process for the Preparation of Methylenecyclopropane | p. 247 |
Synthesis of Cyclopropaneacetylene by a One Pot Process | p. 249 |
Dentrimer | p. 251 |
Dentrimeric Fullerene Derivatives, Process for Their Preparation, and Use as Neurprotectants | p. 251 |
Starburst Conjugates | p. 255 |
Enamines | p. 258 |
Use of Enamines as Light Protection Agents | p. 258 |
Enaminones | p. 261 |
Phenyl-Substituted Cyclic Enaminones | p. 261 |
Ethers | p. 265 |
Diaryl Ether Condensation Reactions | p. 265 |
Preparation and Use of Ionic Liquids in Microwave-Assisted Chemical Transformations | p. 268 |
Wurster's Crown Ligands | p. 270 |
Formazan | p. 272 |
Formazan Metal Complexes | p. 272 |
Furazancarboxylic Acid Derivatives | p. 275 |
Hydroxymethylfurazancarboxylic acid derivatives | p. 275 |
Furanones | p. 278 |
Furanone Derivatives | p. 278 |
Guanidines | p. 280 |
Cyclic Guanidine Derivatives and Their Use as Pesticides | p. 280 |
Guanines | p. 283 |
Substituted O[superscript 6]-Benzyl-8-Aza-Guanines | p. 283 |
Hydrazine | p. 286 |
Diacylhydrazine Derivatives | p. 286 |
Method for Synthesizing Hydrazodicarbonamide | p. 290 |
Imidazole | p. 292 |
Method for Preparing Cycloheptimidazoles | p. 292 |
Substituted Imidazole Compounds | p. 295 |
Imidazolidine | p. 299 |
Cis-Imidazolines | p. 299 |
Spiroimidazolidine Derivatives, Their Preparation, Their use and Pharmaceutical Preparations Formed Therefrom | p. 302 |
Imidazolone | p. 307 |
Fungicidal 2-Imidazolin-5-ones and Imidazoline-5-thiones | p. 307 |
Imidazoltriazionones | p. 311 |
2-Phenyl Substituted Imidazotriazinones as Phosphodiesterase Inhibitors | p. 311 |
Imide Derivatives | p. 315 |
Photocleavable Agents and Conjugates for the Detection and Isolation of Biomolecules | p. 315 |
Process for the Preparation of Alkyl 4[2-(Phthalimido)ethoxy]-Acetoacetate | p. 320 |
Iminocarboxylic Acid Methyl Amides | p. 322 |
Preparation of [alpha]-Methoxyiminocarboxylic Acid Methylamides and Intermediates Therefore | p. 322 |
Indoles | p. 326 |
Process for the Preparation of Indole Derivatives and Intermediates of the Process | p. 326 |
Synthetic Compounds for Treatment of Inflammation | p. 331 |
Tetrahydro-[beta]-Carbolines | p. 333 |
Indoline | p. 337 |
Amination Process | p. 337 |
Isocoumarins | p. 341 |
Process for Preparing Isocoumarins | p. 341 |
Isoxazolines | p. 345 |
Method for Producing Isoxazoline-3-yl-acyl Benzene | p. 345 |
Ketones | p. 349 |
Acetoacetic Acid Derivatives, Process for Their Preparation and Their Use | p. 349 |
Methods for Making Substituted Phenylketoenols | p. 352 |
Process for Preparing 3-Hydroxymethyl-4-(Aryl or Heterocyclic)-Cyclopentanones | p. 355 |
Process for Preparing Trifluoromethyl Ketones | p. 360 |
Process for the Preparation of High Purity Alkyladamanantyl Esters | p. 362 |
Lactams | p. 364 |
Anticonvulsant and Anxiolytic Lactam and Thiolactam Derivatives | p. 364 |
[beta]-Lactams as Antiproliferative Agents | p. 367 |
[beta]-Lactam-like Chaperone Inhibitors | p. 371 |
N-Thiolated [beta]-Lactam Antibiotics | p. 373 |
Process for Preparing [beta]-Lactam Compounds | p. 376 |
6-(Spirocyclopropyl)-Penicillanic Acid-4,4-Dioxides | p. 379 |
Lactones | p. 382 |
Benzylidene-[gamma]-Butryolactones, Process for Their Preparation and Their Use as UV Absorbers | p. 382 |
Ring-Opened Azlactone Initiators for Nitroxide-Mediated Polymerization | p. 385 |
Macocyclic Rings | p. 388 |
[beta]-Diketone Compounds, [beta]-Diketone Compounds Coordinated to Metal, Method of Organic Synthesis with These, and Catalyst | p. 388 |
1,4-Dioxacylcycloalkane-2-one and 1,4-Dioxacylcycloalkene-2-one | p. 392 |
Synthesis of Macrocyclic Tetraamido-N Ligands | p. 394 |
The Preparation of Giant Ring Compounds | p. 397 |
Morpholines | p. 399 |
Lewis Acid-Catalyzed Claisen Rearrangements in the Preparation of Chiral Products | p. 399 |
Naphthopyans | p. 401 |
Indeno-fused Photochromic Naphthopyrans | p. 401 |
Naphthyridines | p. 406 |
4-Hydroxy-1,8-Naphthyridine-3-Carboxamides as Antiviral Agents | p. 406 |
Nitro Derivatives | p. 410 |
Geminal-Dinitro-1,5-Diazocine Derivatives | p. 410 |
Methods of Preparing Salts of Dinitromethane | p. 416 |
Vicarious Nucleophilic Substitution Using 4-Amino-1,2,4-Triazole, Hydroxylamine or O-Alkylhydroxylamine to Prepare 1,3-Diamino-2,4,6-Trinitrobenzene or 1,3,5-Triamine-2,4,6-Trinitrobenzene | p. 418 |
Nitrones | p. 420 |
Furan Nitrone Compounds | p. 420 |
Organometallics | p. 424 |
Aryl Borates | p. 424 |
Boric Ester Synthesis | p. 427 |
Method for Producing Monoaryloxy-ansa-Metallocenes | p. 429 |
Process for Preparing Bisallylboranes and Non-Aromatic Boronic Acids | p. 432 |
Synthetic Molecules That Specifically React with Target Sequences | p. 434 |
Orthocarbonates, Esters, and Derivatives | p. 437 |
Spiroorthocarbonates Containing Epoxy Groups | p. 437 |
Substituted Sprioalkylamino and Alkoxy Heterocyclics, Processes for Their Preparation, and Their Use as Pesticides and Fungicides | p. 441 |
Synthesis of Spiro Orthoesters, Spiro Orthocarbonates, and Intermediates | p. 444 |
Oxadiazines | p. 447 |
Oxadiazine Derivatives | p. 447 |
1,3,4-Oxadiazine Derivatives and Their Use as Pesticides | p. 451 |
Oxathiolanes | p. 454 |
Antiviral Activity and Resolution of 2-Hydroxylmethyl-5-(5-fluorocytosin-1-yl)-1,3-Oxathiolane | p. 454 |
Substituted 1,3-Oxathiolanes with Antiviral Properties | p. 458 |
Oxazines | p. 462 |
Photochromic Oxazine Compounds and Methods for Their Manufacture | p. 462 |
Oxazolidinones | p. 465 |
Process to Prepare Cyclic-Sulfur Fluorine Containing Oxazolidinones | p. 465 |
Oxetanes | p. 470 |
Fluorinated Oxetane Derivatives and Production Process Thereof | p. 470 |
Process for the Production of 3-Alkyl-3-Hydroxymethyloxetanes | p. 473 |
Oxetanones | p. 475 |
Oxetanone Derivatives | p. 475 |
Oximes | p. 478 |
O-Acyloxime Photoinitiators | p. 478 |
Oxime Derivatives and Their Use Thereof as Latent Acids | p. 482 |
Oxirane | p. 484 |
Diels-Adler Adducts of Epoxybutene and Epoxybutene Derivatives | p. 484 |
Process for the Preparation of an Oxirane, Aziridine or Cyclopropane | p. 486 |
Phenols | p. 489 |
Calixarene Derivatives | p. 489 |
Dimeric Arylisoquinoline Alkaloids and Synthesis Method Thereof | p. 493 |
Process for Preparing Procyanidin (4 to 6 or 4 to 8) Oligomers and Their Derivatives | p. 497 |
Piperidine | p. 501 |
N-Acyl Cyclic Amine Derivatives | p. 501 |
Opiate Compounds, Methods of Making and Methods of Use | p. 505 |
Process for Production of Piperidine Derivatives (Note 1) | p. 509 |
Spiropiperidine Derivatives | p. 513 |
Piperizines | p. 517 |
Piperazine Derivatives | p. 517 |
Porphyrins | p. 520 |
1,3-Dipolar Cycloadditions to Polypyrrolic Macrocycles | p. 520 |
Pyrans | p. 522 |
Synthesis of 3,6-Dialkyl-5,6-Dihydro-4-Hydroxy-Pyran-2-One | p. 522 |
Pyrazoles | p. 525 |
Parasiticidal Compounds | p. 525 |
Spiropyrazole Compounds | p. 529 |
Pyridine | p. 532 |
Process for Preparing Tribromomethylsulfonylpyridine | p. 532 |
3-Pyridinyl Compounds | p. 534 |
Pyridone and Tetrahydropyridone | p. 537 |
Pyridone Derivatives, Their Preparation and Their Use as Synthesis Intermediates | p. 537 |
Solid Phase Synthesis of Heterocycles | p. 542 |
Pyrimidines | p. 545 |
N-Heterocyclic Derivatives as NOS Inhibitors | p. 545 |
Pyrrols | p. 548 |
7-Azabicyclo[2.2.1]Heptane and Heptene Derivatives as Cholinergic Receptor Ligands | p. 548 |
Colormetric Sensor Compositions and Methods | p. 552 |
Quinones | p. 555 |
Compositions and Methods for Treating Viral Infections | p. 555 |
Quinone Compound, Liquid Crystal Composition, and Guest-Host-Type Liquid Crystal Cell Employing the Same | p. 559 |
Polycyclic Aryl and Heteroaryl Substituted 1,4-Quinones Useful for Selective Inhibition of the Coagulation Cascade | p. 562 |
Synthesis of Coenzyme Q10 (Ubiquinone) | p. 566 |
Radiolabelled Reagents | p. 570 |
Radioligands and Their Use for Identifying Potassium Channel Modulators | p. 570 |
Synthesis of [superscript 2]H- and [superscript 13]C-Substituted Dithanes | p. 574 |
Tritioacetylating Reagents and Processes for Preparation Thereof | p. 576 |
Saccharides | p. 578 |
2-Saccharinylmethyl Heterocyclic Carboxylates Useful as Proteolytic Enzyme Inhibitors and Compositions and Method of Use Thereof | p. 578 |
Sugars | p. 583 |
Heavily Fluorinated Sugar Analogues | p. 583 |
Preparation of Thioarabinofuranosyl Compounds and Use Thereof | p. 587 |
Process for the Alkaline Oxidative Degradation of Reducing Sugars | p. 591 |
Sugar Derivatives of Hydromorphorine, Dihydromorphorine and Dihydroisomorphorine Compositions Thereof and Uses for Treating or Preventing Pain | p. 594 |
Sulfonamides | p. 597 |
Thioaryl Sulfonamide Hydroxamic Acid Compounds | p. 597 |
Sulfones | p. 602 |
[alpha]-Amino-[beta]-Sulfonyl Hydroxamic Acid Compounds | p. 602 |
Nitromethylthiobenzene Derivatives as Inhibitors of Aldose Reductase | p. 605 |
Process for the Preparation of Ethanesulfonyl-piperidine Derivatives | p. 608 |
[alpha],[beta]-Unsaturated Sulfones for Treating Proliferative Disorders | p. 612 |
Sulfonylimides | p. 615 |
Sulfonylimide Compounds | p. 615 |
Tetrabenazine | p. 618 |
Iodine Derivatives of Tetrabenazine | p. 618 |
Tetracyclines | p. 621 |
7-Substituted Fused Ring Tetracycline Compounds | p. 621 |
Tetrahydrobenzoquinoxaline Diones | p. 624 |
Pyrrolyl Tetrahydrobenzoquinoxaline Diones, Their Preparation and Use As Glutamate Receptor Antagonist | p. 624 |
Tetrahydrobenzothiepines | p. 628 |
Method for the Preparation of Tetrahydrobenzothiepines | p. 628 |
Tetrahydroisoquinolines | p. 633 |
Pictet-Spengler Reaction for the Synthesis of Tetrahydroisoquinolines and Related Heterocyclic Compounds | p. 633 |
Tetrahydroquinolines | p. 635 |
Dimeric Compounds | p. 635 |
Tetrazoles | p. 638 |
Tetrazolyl-Phenyl Actamide Glucokinase Activators | p. 638 |
Thiazoles | p. 643 |
Oxazolo, Thiazolo and Selenazolo [4,5-c]-Quinolin-4-Amines and Analogues Thereof | p. 643 |
Tri-Aryl-Substituted-Ethane PDE4 Inhibitors | p. 646 |
Thiophenes | p. 651 |
3,4-Diaryl Thiopenes and Analogs Thereof Having Use as Anti-inflammatory Agents | p. 651 |
Oligiothiophenes and Synthesis Thereof | p. 655 |
Polyaryl Antitumor Agents | p. 658 |
Triazines | p. 661 |
Aryloxy- and Arylthio-substituted Pyrimidines and Triazines and Derivatives Thereof | p. 661 |
Method of Alkylating Triazine Derivatives | p. 665 |
Triazoles | p. 668 |
One Step Synthesis of 1,2,3-Triazole Carboxylic Acids | p. 668 |
Triazolyl-Tetrazinyl-Aminotriazine Compounds Useful in Pyrotechnic Compositions and Process Thereof | p. 671 |
Trioxolanes | p. 674 |
Spiro and Dispiro 1,2,4-Trioxolane Antimalarials | p. 674 |
Index | p. 677 |