Vulnerability to psychosis : from neurosciences to psychopathology

Early clinical intervention in psychosis is now a major objective of mental health services and the development of specialist intervention services has greatly facilitated research on the early phases of this disorder.

In this book, contributors provide a review of the neurobiological research in people at high risk of psychosis, focusing on the transition from being at a high risk state to their first episode. Contributors consider unaffected family members and twin studies as well as the individual's data before and after the onset of the illness. The environmental factors that contribute to a psychotic episode are also examined.

Vulnerability to Psychosis presents neurobiological findings in the context of what is now known about the psychopathology and cognitive impairments that are evident in people at high risk of psychosis. It will be essential reading for clinicians working with this client group, and will interest academics looking for state of the art information in this field.

Author Notes

Paolo Fusar-Poli is an honorary lecturer and a consultant in adult psychiatry at the Institute of Psychiatry, King's College, London.

Stefan Borgwardt is a psychiatrist, neuroscientist and professor of neuropsychiatry at the University of Basel, Switzerland.

Philip McGuire is a professor of psychiatry and cognitive neuroscience at the Institute of Psychiatry, King's College, London.

Stefan Borgwardt and Paolo Fusar-Poli and Philip McGuireMatthew Broome and Jennifer Dale and Charlotte Marriott and Cristina Merino and Lisa BortolottiAlison R. Yung and Stephen J. Wood and Barnaby NelsonMarco Picchioni and Timothea ToulopoulouFern Day and Carmine ParianteRalf Pukrop and Stephan RuhrmannStefan Borgwardt and Paolo Fusar-Poli and Anita Riecher-Rössler and Philip McGuirePaolo Fusar-Poli and Marta Agosti and Stefan BorgwardtJames M. StoneOliver HowesNicolas Crossley and Elvira BramonLawrence H. Yang and Ahtoy J. Wonpat-Borja and Mark Opler and Michael T. Compton and Meredith Kelly and Valerie Purdie-Vaughns and Cheryl M. CorcoranPhilip McGuire

List of plates	p. vii
List of figures	p. viii
List of tables	p. ix
List of contributors	p. x
Acknowledgements	p. xii
1 Introduction	p. 1
2 Neuroscience, continua and the prodromal phase of psychosis	p. 3
3 Defining the risk for psychosis: Can neuroscience help psychopathology?	p. 23
4 Genetic determinants of the vulnerability to psychosis: Findings from twin studies	p. 41
5 Stress and cortisol in the pre-psychotic phases	p. 59
6 Neurocognitive indicators of high-risk states for psychosis	p. 73
7 Grey matters: Mapping the transition to psychosis	p. 95
8 Functional MRI in prodromal psychosis	p. 105
9 Glutamate: Gateway to psychosis?	p. 117
10 Does dopamine start the psychotic "fire"?	p. 127
11 Neurophysiological alterations in the pre-psychotic phases	p. 147
12 Stigma in early stages of psychotic illness: Connections with cognitive neuroscience	p. 159
13 Conclusions	p. 177
Index	p. 181

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Table of Contents