Advances in chromatographic techniques for therapeutic drug monitoring

For drugs with a narrow therapeutic index, therapeutic drug monitoring methods are essential for patient management. Although immunoassays are commercially available for many drugs and most laboratories use these assays for routine therapeutic monitoring, they have many limitations which hinder their efficacy. Providing practical guidelines for implementing preferred gas and liquid chromatographic methods, Advances in Chromatographic Techniques for Therapeutic Drug Monitoring is a comprehensive reference describing the theory and application of therapeutic drug monitoring in clinical laboratories.

Edited by a distinguished authority in the field and containing contributions from a variety of experts, the book discusses preanalytical variables, the pitfalls of immunoassays, tandem mass spectrometry, issues related to pain management and herbal supplements, and therapeutic drug monitoring for a range of medications, including:

Anticonvulsants Digitalis Cardioactive drugs Antidepressants Immunosuppressants Anti-cancer drugs Vancomycin and aminoglycosides Antibiotics Antiretroviral drugs Nonnarcotic analgesics Anti-inflammatory drugs

Examing older and newer drugs, the book contains detailed discussions on the rationale for therapeutic drug monitoring of each class of drugs, along with their basic pharmacology and toxicology. An extensive list of references is provided at the end of each chapter so that those interested in implementing a new drug assay can find the most appropriate method for the intended drug.

Author Notes

Dr. Amitava Dasgupta is a Professor of Pathology and Laboratory Medicine at the University of Texas Health Sciences Center at Houston. He is also the Director of Clinical Chemistry, Toxicology, and Point of Care Services at the Memorial-Hermann Hospital Laboratories at the University of Texas Medical School at Houston. He received his PhD in chemistry from Stanford University and completed his fellowship in clinical chemistry from the University of Washington at Seattle. He is certified in both clinical chemistry and toxicology by the American Board of Clinical Chemistry. Dr. Dasgupta's major research interest is in the field of therapeutic drug monitoring and he has published 175 papers and numerous reviews and has edited four books. He is on the editorial board of American Journal of Clinical Pathology, Archives of Pathology and Laboratory Medicine, Therapeutic Drug Monitoring, Clinica Chimica Acta, and Journal of Clinical Laboratory Analysis.

Amitava DasguptaValerie BushPradip Datta and Amitava DasguptaGlen L. HortinJoEtta Juenke and Gwendolyn A. McMillinMatthew D. KrasowskiChristine L.H. Snozek and Loralie J. LangmanAmitava DasguptaEdward Peters Womack and Roland Valdes and Saeed A. JortaniRonald W. McLawhonMatthew D. Krasowski and Mohamed G. Siam and Sean EkinsUttam GargKathleen A. Kelly and Anthony W. ButchKimberley Napoli EatonAmitava DasguptaRoger Dean and Amitava DasguptaRonald W. McLawhonNatella Y. Rakhmanina and John N. van den AnkerAmitava DasguptaUttam GargChristine L.H. Snozek and Loralie J. LangmanAmitava Dasgupta

Foreword	p. xi
Preface	p. xiii
Acknowledgments	p. xv
Editor	p. xvii
Contributors	p. xix
Chapter 1 Introduction to Therapeutic Drug Monitoring and Chromatography	p. 1
Chapter 2 Preanalytical Variables and Therapeutic Drug Monitoring	p. 39
Chapter 3 Immunoassays for Therapeutic Drug Monitoring: Pitfalls and Limitations	p. 53
Chapter 4 Introduction to Tandem Mass Spectrometry	p. 69
Chapter 5 Analytical Support of Classical Anticonvulsant Drug Monitoring beyond Immunoassay: Application of Chromatographic Methods	p. 85
Chapter 6 Clinical Practice of Therapeutic Drug Monitoring of New Anticonvulsants	p. 103
Chapter 7 Chromatographic Techniques in the Therapeutic Drug Monitoring of New Anticonvulsants	p. 117
Chapter 8 Problems with Digoxin Immunoassays	p. 133
Chapter 9 Liquid Chromatography Combined with Immunoassay as a Reference Method for Analysis of Digitalis	p. 153
Chapter 10 Chromatographic Methods for Analysis of Cardioactive Drugs	p. 163
Chapter 11 Immunoassays for Tricyclic Antidepressants: Unsuitable for Therapeutic Drug Monitoring?	p. 179
Chapter 12 Chromatographic Techniques for the Analysis of Antidepressants	p. 191
Chapter 13 Pharmacokinetics and Therapeutic Drug Monitoring of Immunosuppressants	p. 209
Chapter 14 Analysis of Immunosuppressants by Liquid Chromatography or Liquid Chromatography with Mass Spectrometry	p. 239
Chapter 15 Therapeutic Drug Monitoring in Cancer Patients: Application of Chromatographic Techniques	p. 299
Chapter 16 Therapeutic Drug Monitoring of Vancomycin and Aminoglycosides with Guidelines	p. 323
Chapter 17 Chromatographic Methods for Analysis of Antibiotics	p. 341
Chapter 18 Need for Therapeutic Drug Monitoring of Antiretroviral Medications in HIV Infection	p. 355
Chapter 19 Chromatographic Techniques for Therapeutic Drug Monitoring of Antiretroviral Drugs	p. 367
Chapter 20 Chromatography in Therapeutic Drug Monitoring of Nonnarcotic Analgesics and Antiinflammatory Drugs	p. 385
Chapter 21 Therapeutic Drug Monitoring in Pain Management: Application of Chromatography and Mass Spectrometry	p. 399
Chapter 22 Investigation of Drug-Herb Interactions: Application of Various Chromatographic Techniques for Analysis of Active Components of Herbal Supplements	p. 425
Index	p. 445

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