Fungi : biology and applications

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Title:

Edition:

2nd ed.

Publication Information:

Hoboken, NJ : John Wiley & Sons, 2011.

Physical Description:

ix,366p. ill.; 25 cm.

ISBN:

9780470977101

9780470977095

Subject Term:

Fungi -- Biotechnology.

Fungi.

Added Author:

Kavanagh, Kevin.

Available:*

Library	Item Barcode	Call Number	Material Type	Item Category 1	Status
Searching... SPACE Kota Bharu Library	30000010118553	TP248.27.F86 F86 2011	Open Access Book	Book	Searching... Unknown
Searching... SPACE Pulau Pinang Library	30000010118552	TP248.27.F86 F86 2011	Open Access Book	Book	Searching... Unknown

Fungi: Biology and Applications , Second Edition provides a comprehensive treatment of fungi, covering biochemistry, genetics and the medical and economic significance of these organisms at introductory level. With no prior knowledge of the subject assumed, the opening chapters offer a broad overview of the basics of fungal biology, in particular the physiology and genetics of fungi and also a new chapter on the application of genomics to fungi. Later chapters move on to include more detailed coverage of topics such as antibiotic and chemical commodities from fungi, new chapters on biotechnological use of fungal enzymes and fungal proteomics, and fungal diseases of humans, antifungal agents for use in human therapy and fungal pathogens of plants.

Graeme M. Walker and Nia A. WhiteMalcolm Whiteway and Catherine BachewichDavid Fitzpatrick and Edgar Mauricio Medina TovarBrendan Curran and Virginia BugejaKevin KavanaghKarina A. Horgan and Richard A. MurphyShauna M. McKelvey and Richard A. MurphyBrendan Curran and Virginia BugejaSean DoyleDerek Sullivan and Gary Moran and David C. ColemanKhaled H. Abu-Elteen and Mawieh HamadFiona Doohan

List of Contributors	p. ix
1 Introduction to Fungal Physiology	p. 1
1.1 Introduction	p. 1
1.2 Morphology of Yeasts and Fungi	p. 2
1.3 Ultrastructure and Function of Fungal Cells	p. 4
1.4 Fungal Nutrition and Cellular Biosyntheses	p. 11
1.5 Fungal Metabolism	p. 21
1.6 Fungal Growth and Reproduction	p. 26
1.7 Conclusions	p. 33
Revision Questions	p. 33
References	p. 34
Further Reading	p. 34
2 Fungal Genetics	p. 37
2.1 Introduction	p. 37
2.2 Fungal Life Cycles	p. 39
2.3 Sexual Analysis: Regulation of Mating	p. 46
2.4 Unique Characteristics of Filamentous Fungi that are Advantageous for Genetic Analysis	p. 51
2.5 Genetics as a Tool	p. 52
2.6 Conclusion	p. 62
Acknowledgement	p. 63
Revision Questions	p. 63
References	p. 64
Further Reading	p. 64
3 Fungal Genomics	p. 67
3.1 Introduction	p. 67
3.2 Genome Sequencing	p. 73
3.3 Bioinformatics Tools	p. 77
3.4 Comparative Genomics	p. 83
3.5 Genomics and the Fungal Tree of Life	p. 87
3.6 Online Fungal Genomic Resources	p. 89
3.7 Conclusion	p. 92
Revision Questions	p. 92
Further Reading	p. 93
4 Fungal Genetics: A Post-Genomic Perspective	p. 95
4.1 Introduction	p. 95
4.2 Genomics	p. 96
4.3 Transcriptomics and Proteomics	p. 106
4.4 Proteomics	p. 110
4.5 Systems Biology	p. 119
4.6 Conclusion	p. 121
Revision Questions	p. 121
References	p. 122
Further Reading	p. 122
5 Fungal Fermentations Systems and Products	p. 125
5.1 Introduction	p. 125
5.2 Fungal Fermentation Systems	p. 126
5.3 Commercial Fungal Products	p. 132
5.4 Conclusion	p. 145
Revision Questions	p. 145
Reference	p. 145
Further Reading	p. 146
6 Pharmaceutical and Chemical Commodities from Fungi	p. 147
6.1 Introduction to Pharmaceutical and Chemical Commodities	p. 147
6.2 Fungal Metabolism	p. 148
6.3 Antibiotic Production	p. 150
6.4 Pharmacologically Active Products	p. 156
6.5 Chemical Commodities	p. 162
6.6 Yeast Extracts	p. 172
6.7 Enriched Yeast	p. 174
6.8 Conclusions	p. 177
Revision Questions	p. 177
References	p. 178
Further Reading	p. 178
7 Biotechnological Use of Fungal Enzymes	p. 179
7.1 Introduction to Enzymes	p. 179
7.2 Enzymes in Industry	p. 180
7.3 Current Enzyme Applications	p. 180
7.4 Future Direction of Industrial Enzymes	p. 186
7.5 Specific Enzymes	p. 186
7.6 Enzyme Production Strategies	p. 201
7.7 Conclusions	p. 202
Revision Questions	p. 203
References	p. 203
Further Reading	p. 203
8 The Biotechnological Exploitation of Heterologous Protein Production in Fungi	p. 205
8.1 Introduction	p. 205
8.2 Heterologous Protein Expression in Fungi	p. 206
8.3 Case Study: Hepatitis B Vaccine: A Billion Dollar Heterologous Protein from Yeast	p. 218
8.4 Further Biotechnological Applications of Expression Technology	p. 222
8.5 Conclusions	p. 227
Revision Questions	p. 227
Further Reading	p. 228
9 Fungal Proteomics	p. 231
9.1 Introduction	p. 231
9.2 Protein Isolation and Purification	p. 234
9.3 Electrophoretic Techniques	p. 237
9.4 Protein Mass Spectrometry	p. 240
9.5 Fungal Proteomics	p. 247
9.6 Specialized Proteomics Applications in Fungal Research	p. 252
9.7 Conclusion	p. 253
Revision Questions	p. 254
Further Reading	p. 254
10 Fungal Infections of Humans	p. 257
10.1 Introduction	p. 257
10.2 Superficial Mycoses	p. 258
10.3 Opportunistic Mycoses	p. 259
10.4 Endemic Systemic Mycoses	p. 273
10.5 Mycotoxicoses	p. 275
10.6 Concluding Remarks	p. 276
Revision Questions	p. 277
Further Reading	p. 278
11 Antifungal Agents for Use in Human Therapy	p. 279
11.1 Introduction	p. 279
11.2 Drugs Targeting the Plasma Membrane	p. 281
11.3 Drugs Targeting the Cell Wall	p. 296
11.4 Drugs Targeting Nucleic Acid and Protein Synthesis	p. 300
11.5 Novel Therapies	p. 304
11.6 Conclusions	p. 310
Revision Questions	p. 310
Reference	p. 311
Further Reading	p. 311
12 Fungal Pathogens of Plants	p. 313
12.1 Fungal Pathogens of Plants	p. 313
12.2 Disease Symptoms	p. 314
12.3 Factors Influencing Disease Development	p. 318
12.4 The Disease Cycle	p. 319
12.5 Genetics of the Plant-Fungal Pathogen Interaction	p. 320
12.6 Mechanisms of Fungal Plant Parasitism	p. 320
12.7 Mechanisms of Host Defence	p. 324
12.8 Disease Control	p. 326
12.9 Disease Detection and Diagnosis	p. 329
12.10 Vascular Wilt Diseases	p. 331
12.11 Blights	p. 334
12.12 Rots and Damping-Off Diseases	p. 336
12.13 Leaf and Stem Spots, Anthracnose and Scabs	p. 338
12.14 Rusts, Smuts and Powdery Mildew Diseases	p. 339
12.15 Global Repercussions of Fungal Diseases of Plants	p. 340
12.16 Conclusions	p. 342
Acknowledgements	p. 342
Revision Questions	p. 342
References	p. 343
Further Reading	p. 343
Answers to Revision Questions	p. 345
Index	p. 363

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