Cover image for Spectroscopic methods and analyses : NMR, mass spectrometry, and metalloprotein techniques
Title:
Spectroscopic methods and analyses : NMR, mass spectrometry, and metalloprotein techniques
Series:
Methods in molecular biology ; 17
Publication Information:
Totowa, NJ : Humana Press, 1993
ISBN:
9780896032156

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30000010133449 QP519.9.N83 S63 1993 Open Access Book Book
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Summary

Summary

The three volumes in Methods in Molecular Biology covering Physical Methods of Analysis (vol. 1, Spectroscopic Methods and Analyses: NMR, Mass Spectrometry, and Metalloprotein Techniques; vol. 2, Optical Spectroscopy and Macroscopic Techniques; vol. 3, Cryst- lographic Methods and Techniques) differ from others in this series in several ways. Each volume covers a group of techniques for the char- terization of biological molecules and their interactions that involve the application of modern techniques of physical chemistry. These techniques by and large do not lend themselves to the "hands-on" approach and cannot usually be carried out by the molecular biologist alone, but most often require collaboration with a specialist. The biologist or biochemist contemplating such a collaboration may feel somewhat at a distance from the experimental work and further isolated by the use of the jargons of analytical and physical chemistry. Physical methods have been used in molecular biology from the earliest days, from simple applications of optical spectroscopy to the complexity of X-ray crystallography, and the full range of these me- ods will be covered over the three volumes. The methods dealt with in this first volume have largely developed from beginnings in small molecule chemistry to the point where they play a valuable role in the characterization of biological macromolecules.


Table of Contents

NMR Spectroscopy: Introduction to Nuclear Magnetic Resonance
Structural Studies of Proteins in Solution Using Proton Nuclear Magnetic Resonance
Peptide Structure Determination by NMR
High-Resolution NMR of DNA and Drug-DNA Interactions
Structural Characterization of the Carbohydrate Moieties of Glycoproteins by High-Resolution 1H-NMR Spectroscopy
The Application of Nuclear Magnetic Resonance to Structural Studies of Polysaccharides
Dynamic and Exchange Processes in Macromolecules Studied by NMR Spectroscopy
Mass Spectrometry: Introduction to Mass Spectrometry
Laser Desorption Ionization Mass Spectrometry of Bioorganic Molecules
252- Californium Plasma Desorption Time-of-Flight Mass Spectrometry of Peptides and Proteins
Fast Atom Bombardment Mass Spectrometry of Peptides
Tandem Mass Spectrometry
Metalloprotein Techniques: Mssbauer Spectroscopy
Electron Paramagnetic Resonance Spectroscopy of Metalloproteins
Resonance Raman Spectroscopy of Metalloproteins Using CW Laser Excitation
The Application of X-Ray Absorption Spectroscopy to Characterize Metal Centers in Proteins
Index