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Summary
Summary
For more than 30 of the most important occupational toxicants, detailed, ready-to-use protocols for human biomonitoring methods are provided. All methods are reliable, reproducible, in accordance with 'Good Laboratory Practice' standards and cover all required steps from sampling to the interpretation of results. This includes data on precision, accuracy, and detection limit, calibration procedures as well as potential sources of systematic errors.
The documented methods are authoritative, because they were compiled by the Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area. The Commission is internationally acknowledged for its neutrality and is working strictly according to transparent, scientific criteria.
Author Notes
Jürgen Angerer is Head of the working group "Analytical Chemistry" of the Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area. He is a member of the International Society of Exposure Analysis (ISEA) and board member of the International Society of Environmental Medicine (ISEM). He is author and editor of numerous books and belongs to the editorial boards of the Journal of Chromatography B as well as of the International Journal of Hygiene and Environmental Health.
Helmut Greim is Head of the DFG-Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area and also President of the Advisory Committee on Existing Chemicals of Environmental Relevance of the German Chemical Society. Both bodies are intimately involved in European regulatory procedures concerning hazardous chemicals.
Table of Contents
| General Aspects |
| Preliminary remarks |
| The use of gas chromatography-mass spectrometry in biological monitoring |
| Substances |
| Acrylonitrile (see N-2-Cyanoethylvalin, N-2 hydroxyethylvalin) |
| Alcohols and Ketones. Antimony, Lead, Cadmium, Platinum, Mercury, Tellurium, Thallium, Bismuth, Tungsten, Tin (ICP-MS collective method) |
| Aromatic Carboxylic Acids (Phenylglyoxylic acid; Mandelic acid; Hippuric acid; o-, m-/p-Methylhippuric acids; Benzoic acid) |
| Arsenic. Benzene (see t,t-Muconic acid) |
| Benzene and alkylbenzenes (BTX aromatics) |
| Beryllium - Standard Addition Procedure. Bismuth (see Antimony) |
| Bitumen (vapour and aerosol) (see PAH) |
| Butoxyacetic acid. Cadmium (see Antimony) |
| Carbon disulfide (see 2-Thioxothiazolidine-4-carboxylic acid (TTCA)) |
| Chloroform (see Halogenated hydrocarbons in blood) |
| Cobalt. Cotinine. N-2-Cyanoethylvaline, N-2-Hydroxyethylvaline, N-Methylvaline (see evidence of exposure to acrylonitrile, ethylene oxide as well as methylating agents) |
| Dimethyl sulfate (see N-2-Cyanoethylvalin, N-2 hydroxyethylvalin) |
| Ethanol (see Alcohols and Ketones) |
| Ethylbenzene (see Benzene and Alkylbenzenes) |
| Ethylene glycol monobutyl ether (Ethylene glycol derivatives) (see Butoxy acetic acid) |
| Ethylene oxide (see N-2-Cyanoethylvalin, N-2-hydroxyethylvalin) |
| Halogenated hydrocarbons (dichloromethane, 1,2-dichloroethylene, 2-bromo-2-chloro-1,1,1-trifluoroethane (halothane), trichloromethane, 1,1,1-trichloroethane, tetrachloromethane, trichloroethylene, tetrachloroethylene) |
| Hexane metabolites (2,5-Hexanedione, 2-Hexanone) |
| Lead (see Antimony) |
| Mercury (see Antimony) |
| t,t-Muconic acid. Organochlorine compounds in whole blood and plasma. PAH metabolites (1-hydroxyphenanthrene, 4-hydroxyphenanthrene, 9-hydroxyphenanthrene, 1-hydroxypyrene) |
| Passive Smoking (see Cotinine in urine) |
| Platinum (see Antimony) |
| Styrene (see Benzene and alkylbenzenes) |
| Tellurium (see Antimony) |
| Tetrachloro ethylene (tetrachloroethene) (see Halogenated Hydrocarbons in blood) |
| Thallium (see Antimony) |
| 2-Thioxothiazolidine-4-carboxylic acid (TTCA) |
| Tin (see Antimony) |
| Trichloroacetic Acid (TCA) |
| Trichloro ethylene (see Trichloro acetic acid in urine) |
| Tungsten (see Antimony) |
| Xylene (all isomers) (see Benzene and alkylbenzenez) |
| Contents of Volume 1-10 |
